A quiet shift in one enzyme may be steering how we age—and how strong we stay. Dr. Helen Blau, trailblazing Stanford scientist and 2025 National Medal of Science honoree, joins us to unpack a breakthrough decades in the making: prostaglandin E2 is essential for muscle stem cell repair, yet a degrading enzyme creeps up with age, draining that signal and eroding strength. Her team calls it a “gerozyme,” and blocking it with a targeted small molecule restored muscle size, power, and endurance in aged mice. The first human safety trial is complete, and a Phase 2 study in sarcopenia is on deck.

We dig into the practical takeaways for athletes and anyone over 50: why the inflammatory wave after training is needed for rebuilding, how common NSAIDs can blunt the very gains you’re chasing, and where a future therapy might help overcome anabolic resistance after illness, injury, or bedrest. Dr. Blau connects the dots across regenerative medicine—tissue‑specific stem cells, iPSCs, and organoids—to show how disease can be modeled in a dish and how patient‑matched cells are speeding smarter drug discovery. We also touch on her early work proving cellular plasticity, new insights on telomeres shortening in heart cells without division, and what “quality” muscle means for safe aging.

Beyond the lab, we talk truth about unproven stem cell clinics, the progress and remaining gaps for women founders in biotech, and the urgent threat of research defunding that stalls clinical trials and drains the talent pipeline. There’s a clear throughline: if we want longer, stronger years—true health span—we need rigorous science, sustained support, and smart training habits that work with our biology, not against it.

If this conversation sparked a shift in how you think about aging and recovery, tap follow, share with a friend who lifts or runs, and leave a review. Your support helps bring evidence‑based breakthroughs to more people—and speeds the path from lab bench to everyday life.

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This BONUS EPISODE is our holiday gift for you! If you're looking for somewhere to offer a holiday or year end gift, please consider directly supporting scientists like Dr. Blau & their labs. Donations keep projects alive while funding is disrupted.

Dr. Blau: https://profiles.stanford.edu/helen-blau?tab=bio

The Lab: https://med.stanford.edu/blau-lab.html

The Book: https://www.amazon.com/Stem-Cells-Rescue-Helen-Blau/dp/1621825280

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What if the presence you practice in mindfulness is the same wiring that makes secure attachment possible? That question drives our conversation with clinician, author, and teacher Christine Forner, who introduces Securefulness—a relational state where an attuned nervous system helps another human co‑regulate. Christine explains why care isn’t sentimental; it’s a biologically essential force that organizes safety, regulation, and health. When true care arrives, dissociated pain often surfaces, which can feel like getting worse. She reframes this as healing beginning and uses a powerful “care isn’t the bucket” story, plus a re-feeding analogy, to show how to pace nourishment without overwhelming the system.

We get practical about what Securefulness looks like in the room: noticing micro‑signals like a shoulder hitch or a shift in breath, naming danger qualities, and adding immediate protections—hoodies, pillows, sunglasses, softened gaze—to reduce social threat and restore choice. Christine shares how therapeutic nurturing has helped clients reduce suicidal ideation within weeks by leveraging presence, titration, and interoception. She also digs into primal isolation threat, how shame language takes root in early deprivation, and we talk about why the inner critic is better replaced by an “inner celebrant” that collaborates with the body’s needs.

Zooming out, we challenge the idea that violence is human nature. Christine defines misogyny as disdain for Homo sapien nurturing and argues that many systems are fight‑state adaptations, not destiny. We explore evolutionary roots of co‑regulation, theory of mind as soothing, and why humans likely evolved in stable, alloparenting communities where care was central. There are signs of change: expanding parental leave, trauma‑informed practice, and evidence that stable resources like universal basic income lower addiction and crime while improving health and learning. If we organize society around care—as infrastructure, not charity—healing gets hard but possible, and repeatable.

If this conversation sparks something in you, share it with a friend, subscribe for future episodes, and leave a review wherever you listen. Your reflections help shape what we explore next—what stood out most to you?

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What does it really take to endure when the air thins, the quads burn, and doubt gets loud? We sit down with ultrarunner Katharina Hartmuth—Hardrock and UTMB podium finisher and winner of the 330 km Tor des Géants—to unpack the mental game of mountain ultras and the deeper work that fuels lasting resilience. From long stretches above 12,000 feet to the rare quiet of a small, devoted race community, Katharina explains why Hardrock feels both brutal and beautiful—and why she keeps coming back.

Katharina is candid about the lows: altitude-driven vision issues, bonks that won’t quit, and the storm-lashed nights where every step is a question. Her toolkit blends practical strategy and inner steadiness—separating pain from harm, checking ego at the door, and letting joy lead and metrics follow. We go further into healing, where she draws a firm line: running is therapeutic, but it isn’t therapy. Years of psychotherapy widened her window of tolerance, rebuilt trust, and turned setbacks into learning. We explore stigma, access, and the biology of stress, showing why mental health care deserves the same respect as injury rehab.

Injuries have tested her in recent years: a car accident, knee surgery, a last-minute bone bruise, and a nagging foot issue. Instead of spiraling, Katharina has learned to reframe recovery as training for patience, leaned on cross-training and strength, and practiced self-kindness that maintains her sense of worth and identity. She also shares how she’s reshaping life for sustainability—creating more rest, more nature, and taking a bold step to focus on running full-time.

If you’re curious about the psychology of endurance, the Hardrock culture, or how therapy and trail running can work together to heal, this conversation is your map. Subscribe, share with a friend who needs encouragement today, and leave a review to help more listeners find the show. What hard thing you’re ready to try next?

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When slowing down feels dangerous, your body might be living in Global High-Intensity Activation(GHIA): always on, always braced, always moving. Today we sit down with licensed marriage and family therapist and Somatic Experiencing faculty member Mahshid Hager to name that pattern, trace where it comes from, and chart a humane path back to rhythm. 

Mahshid explains why a body wired for survival often resists rest, and how to work with that reality using micro-rests that your system will actually allow. We unpack the gas-and-brake reciprocity between sympathetic and parasympathetic systems, the difference between hyperarousal and global high, and how swings between overdrive and full collapse can fuel chronic pain, inflammation, and exhaustion. Along the way, curiosity shows up as the quiet superpower ~ because genuine curiosity cannot coexist with threat.

Mahshid shares a story about her relationship with the mountains over the years, and how the same thing that triggers panic can become a source of awe years later - not with forced exposure, but with care for the body.  We also reflect on capitalism’s applause for burnout and the 24/7 news cycle that delivers shock without local action. You’ll hear smart, doable suggestions for managing news & technology in a way that keeps you engaged , but not overwhelmed.

If you’re always in GO mode, running on fumes, or trying to support clients through trauma, this conversation offers language, tools, and hope. Subscribe, share with a friend who needs a break, and leave a review to help more listeners find their way back to rhythm.

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What if the most powerful medicine starts with warmth, rhythm, and trust in your own body? Today we sit down  down with licensed acupuncturist, Chinese herbalist, and yoga teacher Tara Tonini to trace how trauma-informed Chinese medicine can steady the nervous system, smooth cycles, and support conception, pregnancy, birth prep, and postpartum in a way that fits into real life. From liver qi and kidney jing to the heart-mind connection, Tara translates complex ideas into simple choices you can make today.

We dig into why many people are “acu-curious” yet needle-averse, and how energy work, qigong, and gentle touch can move qi without needles. Tara breaks down yin and yang as a practical parenting tool—intensity peaks, ease returns—and shows how seasonal eating, warm foods, and cozy rituals rebuild blood, improve sleep, and calm anxiety. She shares why chronic heat practices can dry you out, how cold plunges may impact kidney qi, and how warmth is medicine for conception and early postpartum recovery. You’ll hear concrete tips like herbal foot soaks for insomnia, body tapping along meridians to relieve pain, and using familiar yoga postures as targeted meridian stretches for better flow.

We also explore postpartum care through the lens of “sitting the moon,” with nourishing herbs, digestible meals, and home scents that signal safety. Tara’s trauma-informed clinical approach centers consent, pacing, and patient agency. If you’re navigating fertility, preparing for birth, or rebuilding after, this conversation offers grounded tools and a kinder way to meet your body where it is.

If this resonates, follow and share the episode, leave a review on your favorite app, and tell us the practice you’ll try today. Your story might spark someone else’s healing.

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Mothers are asked to offer the critical early childhood care that shapes people and impacts communities, while systems fail to offer them the basic care they need to thrive. 

We invited Dr. Kathleen Kendall-Tackett, health psychologist and IBCLC, to map the real drivers of maternal mental health and the surprisingly simple supports that change everything: responsive care, consistent follow‑through after screening, and communities designed to include mothers instead of isolating them.

We trace the chain from attachment to lifelong outcomes—why secure bonds in the first thousand days predict resilience, school success, and adult health—and why rising ACEs signal a collective failure, not individual weakness. Kathleen challenges outdated hormone‑only narratives and explains how stress systems, trauma history, and cultural fit shape postpartum depression. She shares practical shifts any hospital or community can adopt today: walking groups that blend sunlight and peers, Baby Cafés that normalize feeding and connection, and staff who can spot a painful latch and intervene before a spiral begins. We also dig into sleep: red night lights, keeping baby close, and the counterintuitive finding that exclusive breastfeeding moms often sleep more overall because resettling is faster.

For families and friends asking “how can I help?”, we lay out concrete steps: protect a lying‑in period, offer hands‑on care, screen out unhelpful voices, and create an emergency four‑hour sleep window when she’s hanging by a thread. We look squarely at high‑risk groups, especially military mothers, where depression rates soar—then expand the toolkit with options beyond medication when needed: CBT, acupuncture, omega‑3s, vitamin D. We discuss innovations like rTMS, as well as emerging research on the careful use of ketamine with severe suicidal depression. Cultural trust matters; offering choices increases access and honors lived experience. We close with resources you can use now, from community programs to free postpartum art that normalizes breastfeeding and early parenting.

If this conversation moved you, share it with someone who supports new parents, subscribe for more, and leave a quick review—your words help more families find the care and connection they deserve.

Learn more at: https://praeclaruspress.com/

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What if the moment you stop trying to fix yourself is the moment real relief begins? That’s the surprising turn in our conversation with meditation teacher and parent Cara Lai—authorized in the Theravada lineage (IMS, Spirit Rock) and known for an approach that’s honest, funny, and deeply humane. Cara traces her path from art school and a “soul-sucking” office to early retreats that opened a brighter world, then a year-long retreat that didn’t go to plan. Living with Lyme disease, she discovered that discipline without tenderness can harden into harm, and that the path must be larger than the cushion.

We dig into collective pain, intuition, and the limits of control—how Western culture overvalues productivity while dismissing the “soft” skills that stabilize families and communities. Parenting reframes practice: interruptions became invitations, metta becomes embodied, and desire connect us with life-giving intuition. Cara shares how micro-mindfulness moments—feeling joy fully, pausing in a trigger, relaxing the urge to fix—can change a day. She offers practical on-ramps: start with 8 minutes, consider a short retreat if appropriate, and let nature, humor, and community widen your capacity.

This is a story about the middle way reimagined for modern life: less about perfect posture, more about real presence; less about control, more about trust. If you’ve ever tried to meditate your pain away, if parenting has blown up your schedule, or if softness feels “inefficient,” this conversation offers clarity, compassion, and tools you can use today.

If this resonates, follow and share the show, leave a quick review, and tell us: what will you soften around this week?

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Yoga doesn't have to be perfect to be powerful. That's the refreshing message from Melanie Salvatore August, who brings her background as a classically trained actor, writer, and veteran yoga teacher into a conversation that strips away pretense and gets to the heart of what makes practice sustainable.

Melanie's journey began with meditation books discovered as a preteen and evolved through her years in New York and Los Angeles before motherhood completely transformed her approach. With disarming honesty, she shares how having three children forced her to reimagine what yoga could look like - leading to her book "Kitchen Yoga" and a philosophy of "microhabits within opportunities." These practical strategies include putting self-care tools where you'll actually use them (like a toothbrush in the kitchen drawer) and finding moments for stretching, breathing, or gratitude practice throughout ordinary activities.

The conversation explores her concept of "fierce kindness" - the gentle but firm redirection of ourselves from fear-based patterns toward love and connection. Melanie offers wisdom about pausing before reacting, using awareness of death to prioritize what truly matters, and finding community to support your practice. Her evolution as a teacher reveals how yoga itself has changed, becoming more inclusive and adaptable while still honoring its transformative potential.

Whether you're struggling to start a practice, finding ways to maintain connection through different life seasons, or seeking to deepen your existing relationship with yoga, Melanie's practical wisdom serves as both permission slip and invitation. As she puts it: "Even bad yoga is good yoga" - a reminder that showing up imperfectly is infinitely better than waiting for perfect conditions that rarely arrive. Ready to discover how simple shifts might transform your everyday experience? This conversation shows the way.

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What if the key to living more fully isn’t thinking harder, but reconnecting with your body? In this week’s episode of How We Can Heal, Lisa sits down with actor and teacher Josh Pais to explore what it really means to “lose your mind” and why that might be the best thing you can do.

Josh shares how his father's work as a theoretical physicist alongside Einstein sparked a profound insight: emotions are simply atomic vibrations. This perspective forms the foundation of his groundbreaking approach to acting and authentic living. Rather than labeling sensations as "good" or "bad," Josh invites us to experience them fully as energy moving through our bodies—a practice that can transform anxiety into aliveness, fear into fuel for creativity.

The conversation explores how suppressing sensations disconnects us from our bodies, triggering what Josh calls "the mind"—that abusive internal voice telling us we're not enough. This disconnection doesn't just limit our creative expression; it affects our ability to form genuine connections with others. Whether you're an actor preparing for an audition, an entrepreneur making a presentation, or anyone navigating daily interactions, this pattern of suppression creates barriers between you and authentic engagement.

Josh introduces fascinating concepts like "kinespheres"—energetic patterns extending beyond our physical bodies—and offers practical tools for playing with these energies to transform how we show up in the world. He guides us through understanding impulses as our purest form of self-expression, challenging the cultural conditioning that teaches us to second-guess our natural responses.

Ready to increase your tolerance for the full spectrum of human experience? Josh's approach offers a path to greater aliveness, creativity, and connection—not by changing your thoughts, but by stepping out of them entirely and into the vibrant reality of embodied presence.

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Ever feel like polarization makes meaningful conversation nearly impossible? Dr. Donna Hicks returns with transformative insights on navigating our divided world through dignity consciousness. 

At Harvard's Weatherhead Center for International Affairs, Hicks witnesses dignity violations daily yet remains steadfastly committed to her groundbreaking work. She reveals why these violations feel so viscerally painful – our brains process them identically to physical wounds – and offers practical tools for interrupting our instinctive reactions. Forget counting to ten; taking ten deep breaths actually changes your neurochemistry, creating space for thoughtful response rather than reflexive reaction.

The conversation explores what Hicks calls our "relentless ambivalence" as humans – we simultaneously crave safety through self-preservation and connection through dignity recognition. This tension leaves us constantly choosing which impulse will guide our interactions. When approaching difficult conversations, Hicks recommends genuine curiosity: "I'm really curious about how you arrived at your conclusions." This simple yet profound shift creates safety and honors the other person's inherent worth.

Most powerfully, Hicks shares her vision for a dignity-conscious society built on education and practice. From elementary schools to boardrooms to political chambers, she's witnessing growing receptivity to dignity-based approaches. Her nephew, recently appointed President of Ecuador's National Assembly, explicitly leads with dignity principles – proving these concepts can transform even the most contentious political environments.

For those struggling to connect with their own dignity, Hicks offers this bridge: recognize that unworthiness stems not from personal deficiency but from dignity violations experienced. "I'm worthy, no matter what" becomes possible when we understand "something bad happened to me" rather than "something is wrong with me."

Ready to transform your approach to conflict? Listen now to discover how dignity consciousness can heal our divided world – one conversation at a time.

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