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Episode 67! Today we do a quick overview of the presentations from the Critical Care Reviews 2025 (CCR25) Conference!

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Episode 66! Today we talk about Acute Chest Syndrome in Sickle Cell Disease with one of our favorite hematologists, Benjamin Tillman! We base our discussion around the TASC trial or "Comparison of Prophylactic and Therapeutic Doses of Anticoagulation for Acute Chest Syndrome in Sickle Cell Disease" published by Dessap et al in AJRCCM April of 2025.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/40209087/

AJRCCM: https://www.atsjournals.org/doi/10.1164/rccm.202409-1727OC

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Episode 65! Though this is during ATS, this episode was pre-recorded so you will get some reactions to the conference in the coming episodes. Instead we have a short episode where we talk about risk factors for stress ulcers and transfusion threshold in upper GI bleeding!

Risk factors: https://pubmed.ncbi.nlm.nih.gov/40315134/
Transfusion threshold: https://pubmed.ncbi.nlm.nih.gov/23281973/
Transfusion threshold (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa1211801

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Episode 64! We talk more about steroids in severe community acquired pneumonia with "Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia : The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial" published in Intensive Care Medicine April of 2025.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/40261382/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 63! We talk about intermediate risk PE in "Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism" by Jaber et al published in Circulation in February 2025. Then we talk about "Fibrinolysis for patients with intermediate-risk pulmonary embolism" by Meter et al in NEJM 2014.

PEERLESS: https://pubmed.ncbi.nlm.nih.gov/39470698/
PEITHO: https://pubmed.ncbi.nlm.nih.gov/24716681/
PE Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/24938564/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 62! We talk briefly about two of the analyses that dropped with the ISICEM conference and then talk in depth about SESAR or "Inhaled Sedation in Acute Respiratory Distress Syndrome" by Jabudon et al in JAMA 2025. Then was answer a question on sleep in the ICU. Eddie did misspeak when he said one of the dexmedetomidine articles was in Lancet Respiratory medicine, rather, it was published in eClinical Medicine part of the Lancet network.

SESAR (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2831857
SESAR (pubmed): https://pubmed.ncbi.nlm.nih.gov/40098564/
OVISS (pubmed): https://pubmed.ncbi.nlm.nih.gov/40098600/
Nocturnal dexmedetomidine (pubmed): https://pubmed.ncbi.nlm.nih.gov/29498534/
Nocturnal dexmedetomidine cardiac surgery (pubmed): https://pubmed.ncbi.nlm.nih.gov/36590787/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 61! We talk about HFNC including extubation to HFNC in "Early weaning from invasive mechanical ventilation via high-flow nasal oxygen versus conventional weaning in patients with hypoxemic respiratory failure" by Ayyawar et al published in Critical Care Science. Then we talk about weaning HFNC from the "How I do it" series from CHEST.

Auto-PEEP (NEJM): https://www.nejm.org/doi/full/10.1056/NEJM199307153290322
Extubate to HFNC (pubmed): https://pubmed.ncbi.nlm.nih.gov/39879434/
Extubate to HFNC (CCS): https://criticalcarescience.org/article/early-weaning-from-invasive-mechanical-ventilation-via-high-flow-nasal-oxygen-versus-conventional-weaning-in-patients-with-hypoxemic-respiratory-failure-a-prospective-randomized-controlled-study/
Weaning HFNC (pubmed): https://pubmed.ncbi.nlm.nih.gov/39929280/
Weaning HFNC (CHEST): https://journal.chestnet.org/article/S0012-3692(25)00155-2/abstract

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 60! We jump to SCCM where we talk about 2 late breakers - PROACTIVE or "Propranolol As an Anxiolytic to Reduce the Use of Sedatives for Critically Ill Adults Receiving Mechanical Ventilation" by Downar et al and "Acetylsalicylic Acid Treatment in Patients With Sepsis and Septic Shock" by Almeida et al both published in CCM in 2025. 

PROACTIVE (pubmed): https://pubmed.ncbi.nlm.nih.gov/39982178/
PROACTIVE (CCM): https://pmc.ncbi.nlm.nih.gov/articles/PMC11801419/
ASA in sepsis (pubmed): https://pubmed.ncbi.nlm.nih.gov/39982179/
ASA in sepsis (CCM): https://journals.lww.com/ccmjournal/fulltext/2025/02000/acetylsalicylic_acid_treatment_in_patients_with.2.aspx

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 59! We finish our CCR down under coverage with TRAUMOX2 or "Early Restrictive vs Liberal Oxygen for Trauma Patients" published in JAMA by Arleth et al and then switch to SAHARA or "Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage" by English et al published in NEJM. We then frustrate Todd with questions from our mailbag, a good episode!

TRAUMOX2 (pubmed): https://pubmed.ncbi.nlm.nih.gov/39657224/
TRAUMOX2 (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2827980
SAHARA (pubmed): https://pubmed.ncbi.nlm.nih.gov/39655786/
SAHARA (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2410962

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 58! We talk about non-invasive oxygen support and RENOVATE or "High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure" published in JAMA December 2024 and presented at the CCR Down Under Conference. We supplement this by first talking about FLORALI or "High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure" published in NEJM May 2015

RENOVATE (pubmed): https://pubmed.ncbi.nlm.nih.gov/39657981/
RENOVATE (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2828065
FLORALI (pubmed): https://pubmed.ncbi.nlm.nih.gov/25981908/
FLORALI (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa1503326

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!