Send us a Text Message (please include your email so we can respond!)

Episode 75! We talk about melatonin! We highlight MELLOW because it has the best acronym (by Burry et al in CHEST 2025). Then we dive into our mailbag!

MELLOW: https://pubmed.ncbi.nlm.nih.gov/39800236/

DEMEL: https://pubmed.ncbi.nlm.nih.gov/40608082/

Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/40662882/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 74! We talk about the history and current practice of SBTs with "Providers Consistently Delay Extubation After Successful Spontaneous Breathing Trials" by Barker et al in Annals of the ATS and the original 1996 SBT article by Ely et al in NEJM.

SBT: https://pubmed.ncbi.nlm.nih.gov/8948561/

SBT (NEJM): https://www.nejm.org/doi/10.1056/NEJM199612193352502

SBT Timing: https://pubmed.ncbi.nlm.nih.gov/40393063/

SBT Timing (Annals ATS): https://www.atsjournals.org/doi/10.1513/AnnalsATS.202502-188OC

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

We are (were) LIVE at ACNP Critical Care Bootcamp 2025! Thank you to the organizers of the conference for inviting us do a live show and thank you to everyone who came out to listen! We talk about the PIC trial or "Adjunctive corticosteroids in non-AIDS patients with severe Pneumocystis jirovecii pneumonia" by Lemiale et al published in the Lancet Respiratory Medicine September 2025

PIC (pubmed): https://pubmed.ncbi.nlm.nih.gov/40652952/
PIC (LRM): https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00125-0/abstract

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 72! We continue talking about the articles from the CCR25 conference with UK-ROX or "Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients" published in JAMA 2025 by Martin et al and TARGET-Protein or "Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit" by Jaber et al in Lancet 2018.

UK-ROX: https://pubmed.ncbi.nlm.nih.gov/40501321/

UK-ROX (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2835384

TARGET-Protein: https://pubmed.ncbi.nlm.nih.gov/40495743/

TARGET-Protein (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2835302

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 71! We continue talking about the articles from the CCR25 conference with FLUID or "A Crossover Trial of Hospital-Wide Lactated Ringer's Solution versus Normal Saline" published in NEJM 2025 by McIntyre et al and our old article is BICAR-ICU or "Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit" by Jaber et al in Lancet 2018.

FLUID: https://pubmed.ncbi.nlm.nih.gov/40503714/

FLUID (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2416761

BICAR-ICU: https://pubmed.ncbi.nlm.nih.gov/29910040/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 70! In this episode we have a special guest, Wes Ely, join us to talk about A2B or "Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients" by Walsh et al published in JAMA May of 2025. A long discussion but a good one, don't miss this one!

Pubmed: https://pubmed.ncbi.nlm.nih.gov/40388916/

JAMA: https://jamanetwork.com/journals/jama/article-abstract/2834276

Editorial: https://jamanetwork.com/journals/jama/article-abstract/2834277

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 69! We start talking about the articles from the CCR25 conference with RESCUE-3 or "Temporary Transvenous Diaphragm Neurostimulation for Weaning from Mechanical Ventilation" published in AJRCCM by Dres et al and PROMIZING or "Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation" by Bosma et al in NEJM.

RESCUE-3 (pubmed): https://pubmed.ncbi.nlm.nih.gov/40498082/

PROMIZING (pubmed): https://pubmed.ncbi.nlm.nih.gov/40513024/

PROMIZING (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2505708

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 68! Today we talk about modes of mechanical ventilation with the first author Dr. Kevin Seitz. This was published in CHEST April of 2025 as "Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial".

Disclaimer, this is stated in the episode but Todd and I are authors on this paper. Please keep that in mind as you enjoy the episode!

Pubmed: https://pubmed.ncbi.nlm.nih.gov/40189043/

CHEST: https://journal.chestnet.org/article/S0012-3692(25)00417-9/fulltext

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 67! Today we do a quick overview of the presentations from the Critical Care Reviews 2025 (CCR25) Conference!

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Send us a Text Message (please include your email so we can respond!)

Episode 66! Today we talk about Acute Chest Syndrome in Sickle Cell Disease with one of our favorite hematologists, Benjamin Tillman! We base our discussion around the TASC trial or "Comparison of Prophylactic and Therapeutic Doses of Anticoagulation for Acute Chest Syndrome in Sickle Cell Disease" published by Dessap et al in AJRCCM April of 2025.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/40209087/

AJRCCM: https://www.atsjournals.org/doi/10.1164/rccm.202409-1727OC

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!