The conclusion of the Candida trilogy focuses on the rise of the Lord of the Candida resistance mechanisms: C. auris.

Alyssa and Callum are joined by returning guest Professor Tihana Bicanic to discuss the rise of C. auris. Here we highlight some resources for managing this difficult to treat Candida including the recent UKHSA updated guidelines. 

We also discuss anti-fungal resistance mechanisms in Candida in general.

Although this concludes the Candidal section, there are more yeasts yet to come!

Show notes for this episode here: https://idiots.notion.site/108-110-Yeasts-Candida-0eb5f9271f654312b59458d39f8de603?pvs=74 

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Yes we've done a Candida episode, but what about SECOND Candida episode?

This week in the second part of the Candida Trilogy Alyssa and Callum are joined by Professor Tihana Bicanic to discuss all things invasive Candidiasis.

Listen in to hear about treatment and diagnosis of this important condition, as well as some areas of current research and the most recent guidelines from ECMM-ISHAM. (Note this episode was recorded before they were released).

Show notes for this episode here: https://idiots.notion.site/108-110-Yeasts-Candida-0eb5f9271f654312b59458d39f8de603?pvs=74 

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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In this episode there will be puns where you yeast expect them...

But more seriously, what does Candida albicans actually mean? What are yeasts anyway? How does this all relate to the Romans?

These questions, and more, will be answered as Alyssa and Callum continue the Fungal series with this, the first in a 3-parter on all things Candida!

In this episode we cover the Taxonomy (newly confusing), Epidemiology and Pathogenesis of Candida spp. before talking about superficial candidiasis.

Look out for upcoming episodes on invasive Candidiasis and C. auris!

Show notes for this episode here: https://idiots.notion.site/108-110-Yeasts-Candida-0eb5f9271f654312b59458d39f8de603?pvs=74 

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Questions, comments, suggestions to [email protected] or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
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What exciting times! Clinical trials into the management of SAB! SNAP publication on the horizon! 

But how do we interpret and apply the results of these trials to our patients? This week Jame and Callum are joined by Dr Clark Russell, Clinical Lecturer in Infectious Diseases to discuss:

1. The difficulty in interpreting current clinical trials in SAB.
2. The emerging concept of "low risk" SAB and how to define this.
3. The heterogeneity of SAB and how this might be exploited.

Notes for this episode here: https://idiots.notion.site/107-SAB-update-1316a1ea09d8800ba701ca7ebc8d4093 

Previous episodes for the basics of Staphylococcus aureus and SABATO & SNAP trials:

1. It starts with Staph

65. SNAP trial protocol

72. SABATO trial & 73. SABATaddendum

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Callum and Alyssa are joined by Professor Malcolm Richardson to talk about all things fungal diagnostics.

In this, part 1 of 2 on diagnostics we discuss the use of biomarkers such as beta-D-Glucan and galactomannan, as well as serology and molecular techniques.

Notes for this episode can be found: here.

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Callum and Alyssa are joined by Professor Malcolm Richardson to talk about all things fungal diagnostics.

In this, part 1 of 2 on diagnostics we discuss the use of microscopy, histopathology and culture in diagnosing fungal infections.

Notes for this episode can be found: here.

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
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IT'S A BREAKPOINTS BREAKOUT!

Jame and Callum are joined by the drugnamic duo of Julie-Ann Justo & Erin McCreary from the Breakpoints podcast to delve into the IDSA DTR Gram negative Guidance.

Show notes for this episode are here.

Breakpoints podcast can be found here: https://breakpoints-sidp.org/

Lyrics: 

Tryin’ to use some drugs to kill these bugs

Erin and Julie are PK PD thugs 

Gonna make these two ID:IOTS look like mugs

It’s gonna be a Breakpoints Breakout

Sorry the song sounds so tinny, Podcast host is doing something strange to it. Link to original MP3 here. 

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My my! Mycology?

Join Callum and special co-host Alyssa for this, the first in the all new ID:IOTS Mycology Mega-series.

Here we cover:

1. What the British Society of Medical Mycology is and what they do 
2. Why we're doing this series on fungi  
3. The Global and UK Burden of fungal disease. 
4. The spectrum of fungal disease clinically, 
5. The taxonomy of these pathogens, 
6. and the WHO Fungal Pathogen List.

Notes for this episode can be found here.

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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So now, Loyal Listener, you know all about Susceptible, Sensitive at higher doses, Resistant, MICs, ECOFFs/ECVs and how to use the EUCAST breakpoints table....

But what about the wild-west of bug-drug combos where there are no breakpoints?

Well in this episode, Jame and Callum talk through the EUCAST approach to this situation.

Show notes for this episode here

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BREAKPOINTS. We all love them. S breakpoints... R breakpoints... dash, IE, NA...

Wait, dash, IA, NA, Brackets?!

LISTEN ON (and read the accompanying prep notes), and soon you'll know! In this episode Jame and Callum talk through the EUCAST breakpoints table and how to interpret it

Show notes for this episode here

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Questions, comments, suggestions to [email protected] or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
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