George Stark from the Cleveland Clinic reflects on his early training in biochemistry and how several sabbatical leaves sparked pivotal changes in his research trajectory, eventually drawing him to interferon signaling where he helped establish the core principles of the JAK–STAT pathway and uncovered interesting roles for interferon signaling in cancer.

Host: Cindy Leifer

Guest: George Stark

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Links for this episode

• MicrobeTV Discord Server
• Stark lab
• Development of the Northern blotting technique (PNAS, 1977)
• Development of Western blotting for proteins (PNAS, 1979)
• Discovery of Tyk2 as a critical kinase in interferon response (Cell, 1992)
• Topical PALA treatment for non-melanoma skin cancer (Exp Dermatol, 2023)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Information on this podcast should not be construed as medical advice.