Melvyn Bragg and guests discuss how the Black Death influenced the structure and ideas of Medieval Europe. In October 1347, a Genoese trading ship arrived at the busy port of Messina in Sicily and docked among many similar ships doing similar things. But this ship was special because this ship had rats and the rats had fleas and the fleas had plague. This was the Black Death and its terrible progress was captured by the Florentine writer Giovanni Boccaccio who declared “in those years a dead man was then of no more account than a dead goat”. In the long and unsanitary history of Europe there have been many plagues but only one Black Death. It killed over a third of Europe’s population in 4 years – young and old, rich and poor, in the town and in the country. When it stopped in 1351 it left a continent ravaged but transformed – the poor found their labour to be valuable, religion was both reinforced and undercut, medicine progressed, art changed and the continent awash with guilt and memorialisation. With Miri Rubin, Professor of Medieval and Early Modern History at Queen Mary, University of London; Samuel Cohn, Professor of Medieval History at the University of Glasgow; Paul Binski, Professor of the History of Medieval Art at Gonville and Caius College, University of Cambridge

Melvyn Bragg and guests discuss the Library at Nineveh, a treasure house of Assyrian ideas from the 7th Century BC. In 1849 a young English adventurer called Henry Layard started digging into a small hill on the banks of the River Tigris in Northern Iraq. Underneath it he found the ancient city of Nineveh. Layard unearthed extraordinary things - wonderful carved reliefs, ancient palace rooms and great statues of winged bulls. He also found a collection of clay tablets, broken up, jumbled around and sitting on the floor of a toilet. It was the remnants of a library and although Layard didn’t know it at the time, it was one of the greatest archaeological finds ever made.Conceived to house the sum of all human knowledge the library was built in the 7th century BC as the grand Assyrian Empire entered its last years. The clay tablets have proved to be a window into all aspects of Assyrian life, its literature, politics, religion and medicine – practises that are both deeply alien to us and alluringly familiar. With Eleanor Robson, Senior Lecturer at Cambridge University and Vice-Chair of the British Institute for the Study of Iraq; Karen Radner, Lecturer in the Ancient Near Eastern History at University College London; Andrew George, Professor of Babylonian at the School of Oriental and African Studies at the University of London

Melvyn Bragg and guests discuss the history of ideas about the human brain. Since time immemorial people have puzzled over the brain and its functions. In the 5th century BC the Greek physician Hippocrates confidently asserted:“Men ought to know that from the brain and from the brain only arise our pleasures, joys, laughter and jests, as well as our sorrows, pains, grieves and tears.” This might suggest that people have never doubted the importance of the brain, but for Aristotle the heart was the ruler of the body and the seat of the soul. Only in the 17th century, with new scientific advances, did the true importance of the brain begin to be appreciated. In 1669 the Danish anatomist, Nicolaus Steno, still lamented that, “the brain, the masterpiece of creation, is almost unknown to us.”How far have our perceptions of how the brain works and what it symbolises changed over the centuries? And, in amongst the matter or our little grey cells, are we still searching for our souls? With Vivian Nutton, Professor of the History of Medicine at University College London; Jonathan Sawday, Professor of English Studies at the University of Strathclyde; Marina Wallace, Professor at the University of the Arts, London, Central St Martin’s College of Art and Design

Melvyn Bragg and guests discuss the enclosure movement of the 18th and 19th centuries. In the early 19th century, the Northamptonshire poet John Clare took a good look at the countryside and didn’t like what he saw. He wrote: "Fence meeting fence in owners little boundsOf field and meadow, large as garden-grounds,In little parcels little minds to please,With men and flocks imprisoned, ill at ease."Enclosure means literally enclosing a field with a fence or a hedge to prevent others using it. This seemingly innocuous act triggered a revolution in land holding that dispossessed many, enriched a few but helped make the agricultural and industrial revolutions possible. It saw the dominance of private property as the model of ownership, as against the collective rights of previous generations. For some Enclosure underpinned the economic and agricultural development of Modern Britain. But it has also been a cause celebre for the political left ever since Karl Marx argued that enclosures created the industrialised working class and ushered in the capitalist society. What really happened during the era of 18th and 19th century enclosures? Who gained, who lost and what role did Enclosures play in the agricultural and industrial transformation of this country? With Rosemary Sweet, Director of the Centre for Urban History at the University of Leicester; Murray Pittock, Bradley Professor of English Literature at the University of Glasgow; Mark Overton, Professor of Economic and Social History at the University of Exeter.

Melvyn Bragg and guests discuss Materialism in Philosophy – the idea that matter and the interactions between matter account for all that exists and all that happens. We trace the descent of materialism from the ancient Greek philosophers Democritus and Epicurus, to its powerful and controversial flowering in the 17th, 18th and 19th centuries as an attack on religion. It’s provocative stuff even today and certainly was in 1770 when Baron D’Holbach published his book The System of Nature. He wrote: "If we go back to the beginning we shall find that ignorance and fear created the gods; that fancy, enthusiasm, or deceit adorned or disfigured them; that weakness worships them; that credulity preserves them, and that custom, respect and tyranny support them."Materialism was considered so dangerous that every copy of the Baron’s book was condemned to be burnt. Despite this, or perhaps because of it, materialism dominates much of our understanding of the world today. Associated with science and atheism, Materialism has influenced many forms of contemporary human thought from the process of history to the diagnosis of disease and boasts a cast list of devotees including Pierre Gassandi, Thomas Hobbes, the Marquis de Sade and Karl Marx. But what does materialism really mean, how has it developed over time and can we still have free will if we are living in a materialist world? With Anthony Grayling, Professor of Philosophy at Birkbeck College, University of London; Caroline Warman, Fellow of Jesus College, Oxford; Anthony O’Hear, Professor of Philosophy at the University of Buckingham

Melvyn Bragg and guests discuss the poet W.B. Yeats and Irish politics. Yeats lived through a period of great change in Ireland from the collapse of the home rule bill through to the Easter Rising of 1916 and the partitioning of the country. In May 1916, 15 men were shot by the British government. They were the leaders of the Easter Rising – a doomed attempt to overthrow British rule in Ireland - and they were commemorated by W.B. Yeats in a poem called Easter 1916. It ends with the following lines: MacDonagh and MacBrideAnd Connolly and PearseNow and in time to be,Wherever green is worn,Are changed, changed utterly:A terrible beauty is born.Yeats lived through decades of turbulence in Ireland. He saw the suspension of home rule, civil war and the division of the country, but how did the politics of the age imprint themselves on his poetry, what was the nature of Yeats’ own nationalism, and what did he mean by that most famous of phrases ‘a terrible beauty is born’?With Roy Foster, Carroll Professor of Irish History at Oxford University and Fellow of Hertford College, Oxford; Fran Brearton, Reader in English at Queen’s University, Belfast and Assistant Director of the Seamus Heaney Centre for Poetry; Warwick Gould, Director of the Institute of English Studies in the School of Advanced Study, University of London

Melvyn Bragg and guests discuss ‘the Norman Yoke’ – the idea that the Battle of Hastings sparked years of cruel oppression for the Anglo Saxons by a Norman ruling class. ‘Norman saw on English oak,On English neck a Norman yoke;Norman spoon in English dish,And England ruled as Normans wish.’Taken from Sir Walter Scott’s novel ‘Ivanhoe’, these words encapsulate the idea of ‘the Norman Yoke’ – that the Battle of Hastings sparked the cruel oppression of Anglo-Saxon liberties by a foreign ruling class. Certainly, William the Conqueror proclaimed his power in great castles and cathedrals, turned the church upside down and even changed the colour of scribal ink. But was it really such a terrible time for the Anglo Saxons or was the idea of beastly Norman oppressors and noble Saxon sufferers invented later to shore up the idea of Englishness? With Sarah Foot, Regius Professor of Ecclesiastical History at Christ Church, Oxford; Richard Gameson, Professor in the Department of History at Durham University; Matthew Strickland, Professor of Medieval History at the University of Glasgow.

Melvyn Bragg and guests discuss Newton’s Laws of Motion. In 1687 Isaac Newton attempted to explain the movements of everything in the universe, from a pea rolling on a plate to the position of the planets. It was a brilliant, vaultingly ambitious and fiendishly complex task; it took him three sentences. These are the three laws of motion with which Newton founded the discipline of classical mechanics and conjoined a series of concepts - inertia, acceleration, force, momentum and mass - by which we still describe the movement of things today. Newton’s laws have been refined over the years – most famously by Einstein - but they were still good enough, 282 years after they were published, to put Neil Armstrong on the Moon. With Simon Schaffer, Professor in History and Philosophy of Science at the University of Cambridge and Fellow of Darwin College; Raymond Flood, University Lecturer in Computing Studies and Mathematics and Senior Tutor at Kellogg College, University of Oxford; Rob Iliffe, Professor of Intellectual History and History of Science at the University of Sussex.

Melvyn Bragg and guests discuss Henry VIII and the Dissolution of the Monasteries. Was Henry’s decision to destroy monastic culture in this country a tyrannical act of grand larceny or the pious destruction of a corrupt institution? When he was an old man, Michael Sherbrook remembered the momentous events of his youth: “All things of price were either spoiled, plucked away or defaced to the uttermost…it seemed that every person bent himself to filch and spoil what he could. Nothing was spared but the ox-houses and swincotes…” He was talking about the destruction of Roche Abbey, but it could have been Lewes or Fountains, Glastonbury, Tintern or Walsingham, names that haunt the religious past as their ruins haunt the landscape. These were the monasteries, suddenly and for many shockingly, destroyed during the reign of Henry VIII.The conflict was played out with a mix of violence, heroism, political manoeuvring and genuine theological disputation. But what was lost in terms of architecture, painting, treasure and in the religious habits of the monasteries themselves and of the common people who lived with them?With Diarmaid MacCulloch, Professor of the History of the Church at Oxford University; Diane Purkiss, Fellow and Tutor at Keble College, Oxford; George Bernard, Professor of Early Modern History at the University of Southampton

Melvyn Bragg and guests discuss the rich and radical ideas of Soren Kierkegaard, often called the father of Existentialism.In 1840 a young Danish girl called Regine Olsen got engaged to her sweetheart – a modish and clever young man called Søren Kierkegaard. The two were deeply in love but soon the husband to be began to have doubts. He worried that he couldn’t make Regine happy and stay true to himself and his dreams of philosophy. It was a terrible dilemma, but Kierkegaard broke off the engagement – a decision from which neither he nor his fiancée fully recovered. This unhappy episode has become emblematic of the life and thought of Søren Kierkegaard - a philosopher who confronted the painful choices in life and who understood the darker modes of human existence. Yet Kierkegaard is much more than the gloomy Dane of reputation. A thinker of wit and elegance, his ability to live with paradox and his desire to think about individuals as free have given him great purchase in the modern world and he is known as the father of Existentialism.With Jonathan Rée, Visiting Professor at Roehampton University and the Royal College of Art; Clare Carlisle, Lecturer in Philosophy at the University of Liverpool; John Lippitt, Professor of Ethics and Philosophy of Religion at the University of Hertfordshire.