In this episode, Dr. Madhuri Sopirala, Medical Director and Chief of Infection Prevention at Parkland Health and Chair of SHEA’s Infection Prevention and Control Burn Unit Special Interest Group, moderates a timely conversation on the unique challenges of infection prevention in burn units. She is joined by Dr. Samuel Mandell, Associate Professor of Surgery at UT Southwestern and Director of the Parkland Regional Burn Center, and Dr. David Weber, Distinguished Professor of Medicine and Medical Director of Infection Prevention at UNC Medical Center, as well as current SHEA Board of Trustees President. Together, they explore why burn units require specialized approaches to infection prevention, the nuances of distinguishing outbreaks from baseline infection risks, and strategies for optimizing burn unit design to improve patient safety. The discussion also highlights often-overlooked vectors of infection, emerging research priorities, and what the future may hold for advancing infection prevention in burn care.