In this episode, Valentin Fuster reviews the September 17, 2024, JACC issue, highlighting pivotal studies on metabolic surgery's impact on cardiovascular risk in obstructive sleep apnea patients, and the potential of DPP-4 inhibitors in aortic valve calcification. He also discusses the benefits of Sitagliptin for heart failure and the prognostic value of plasma immunoglobulins in pulmonary arterial hypertension, closing with a look at genotype-guided antiplatelet therapy.