This month, Executive Editor Michael Roy talks with M. Camille Hoffman, M.D., about her research on the use of nutritional supplements in pregnancy. Michael Roy also speaks with Daniel S. Pine, M.D., Deputy Editor of the Journal, about a clinical trial involving ketamine and whether a framework can be established for the safe use of ketamine. Other highlights: how physical activity can affect depression, and treatment of alcohol-dependent adults who are involved with the criminal justice system.