In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Andrea Maier, Professor in Medicine and Director of the NUS Academy for Healthy Longevity at the National University of Singapore’s School of Medicine. They explore what the evidence shows on supplements, and why “test, then treat” beats guesswork. Andrea unpacks a review of over 5 million people: multivitamins may support memory and lower systolic blood pressure in some older or at-risk groups, but offer little for healthy adults. She also reports lab audits of Nicotinamide Mononucleotide (NMN) and urolithin A, in which many products fell short of the label claims. She then sorts buzzworthy compounds like alpha-ketoglutarate, spermidine, curcumin, and melatonin by mechanism, trial quality, and fit. Her rule stays simple: measure what you can, match the dose to the need, and track outcomes with walking speed, grip strength, steps, and wearable sleep data over time, not once.  Guest-at-a-Glance<a href='https://www.linkedin.com/in/urialonw/'>💡 Name: Dr. Andrea Maier 💡 What she does: Professor in Medicine, Healthy Ageing and Dementia Research, and Director of the NUS Academy for Healthy Longevity 💡 Company: the National University of Singapore’s School of Medicine 💡 Noteworthy: She runs human trials on supplements and aging, audits label accuracy in the lab, and pushes a “measure first” approach using biomarkers, wearables, and simple strength tests. 💡 Where to find her:</a><a href='https://www.linkedin.com/in/andreamaierprof'> https://www.linkedin.com/in/andreamaierprof </a>💡 Guest Company Website:<a href='https://discovery.nus.edu.sg/19564-andrea-britta-maier'> https://discovery.nus.edu.sg/19564-andrea-britta-maier</a>   Episode highlights:[00:00:00]: Introduction [00:01:02]: Overview of Evidence-Based Clinical Practice [00:02:16]: Multivitamins and Minerals: Usage and Population Trends [00:04:08]: Systematic Review Findings on Multivitamins and Cognitive Health [00:05:44]: Who Benefits Most from Multivitamin Supplementation [00:06:57]: Personalized Nutrition and the Case for Targeted Supplementation [00:08:21]: Ongoing Clinical Trials on Multivitamins and Biological Age [00:09:19]: Supplement Quality: Label Claims Versus Actual Content [00:12:14]: Navigating Supplement Quality and Consumer Guidance [00:14:53]: Novel Longevity Compounds: Alpha-Ketoglutarate [00:17:47]: Alpha-Ketoglutarate: Human Evidence and Population Focus [00:18:29]: Spermidine: Dietary Sources and Human Evidence [00:21:25]: Curcumin: Mechanisms, Evidence, and Target Populations [00:24:54]: Evaluating Supplements for Clinical Use [00:27:08]: Scientific Approach to Supplement Research [00:29:26]: The Role of Independent Research in Supplement Evaluation [00:32:37]: Melatonin: Sleep, Jet Lag, and Circadian Rhythm [00:37:25]: Practical Melatonin Use for Travel and Sleep Optimization [00:41:05]: Digital Biomarkers: Definition and Emerging Role [00:45:54]: Integrating Digital Biomarkers into Healthcare Practice [00:49:05]: Physical Function Tests: Grip Strength and Sit-to-Stand [00:59:48]: NAD Precursors: NMN, NR, and Human Trials [01:05:23]: NAD Testing: Current Landscape and Future Directions [01:07:24]: Final Takeaways and Closing Remarks    For science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Andrea Maier, Professor in Medicine and Director of the NUS Academy for Healthy Longevity at the National University of Singapore’s School of Medicine. They explore what the evidence shows on supplements, and why “test, then treat” beats guesswork. Andrea unpacks a review of over 5 million people: multivitamins may support memory and lower systolic blood pressure in some older or at-risk groups, but offer little for healthy adults. She also reports lab audits of Nicotinamide Mononucleotide (NMN) and urolithin A, in which many products fell short of the label claims. She then sorts buzzworthy compounds like alpha-ketoglutarate, spermidine, curcumin, and melatonin by mechanism, trial quality, and fit. Her rule stays simple: measure what you can, match the dose to the need, and track outcomes with walking speed, grip strength, steps, and wearable sleep data over time, not once. Guest-at-a-Glance 💡 Name: Dr. Andrea Maier 💡 What she does: Professor in Medicine, Healthy Ageing and Dementia Research, and Director of the NUS Academy for Healthy Longevity 💡 Company: the National University of Singapore’s School of Medicine 💡 Noteworthy: She runs human trials on supplements and aging, audits label accuracy in the lab, and pushes a “measure first” approach using biomarkers, wearables, and simple strength tests. 💡 Where to find her: https://www.linkedin.com/in/andreamaierprof 💡 Guest Company Website: https://discovery.nus.edu.sg/19564-andrea-britta-maier Episode highlights: [00:00:00]: Introduction [00:01:02]: Overview of Evidence-Based Clinical Practice [00:02:16]: Multivitamins and Minerals: Usage and Population Trends [00:04:08]: Systematic Review Findings on Multivitamins and Cognitive Health [00:05:44]: Who Benefits Most from Multivitamin Supplementation [00:06:57]: Personalized Nutrition and the Case for Targeted Supplementation [00:08:21]: Ongoing Clinical Trials on Multivitamins and Biological Age [00:09:19]: Supplement Quality: Label Claims Versus Actual Content [00:12:14]: Navigating Supplement Quality and Consumer Guidance [00:14:53]: Novel Longevity Compounds: Alpha-Ketoglutarate [00:17:47]: Alpha-Ketoglutarate: Human Evidence and Population Focus [00:18:29]: Spermidine: Dietary Sources and Human Evidence [00:21:25]: Curcumin: Mechanisms, Evidence, and Target Populations [00:24:54]: Evaluating Supplements for Clinical Use [00:27:08]: Scientific Approach to Supplement Research [00:29:26]: The Role of Independent Research in Supplement Evaluation [00:32:37]: Melatonin: Sleep, Jet Lag, and Circadian Rhythm [00:37:25]: Practical Melatonin Use for Travel and Sleep Optimization [00:41:05]: Digital Biomarkers: Definition and Emerging Role [00:45:54]: Integrating Digital Biomarkers into Healthcare Practice [00:49:05]: Physical Function Tests: Grip Strength and Sit-to-Stand [00:59:48]: NAD Precursors: NMN, NR, and Human Trials [01:05:23]: NAD Testing: Current Landscape and Future Directions [01:07:24]: Final Takeaways and Closing Remarks For science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Andrea Maier, Professor in Medicine and Director of the NUS Academy for Healthy Longevity at the National University of Singapore’s School of Medicine. They explore what the evidence shows on supplements, and why “test, then treat” beats guesswork. Andrea unpacks a review of over 5 million people: multivitamins may support memory and lower systolic blood pressure in some older or at-risk groups, but offer little for healthy adults. She also reports lab audits of Nicotinamide Mononucleotide (NMN) and urolithin A, in which many products fell short of the label claims. She then sorts buzzworthy compounds like alpha-ketoglutarate, spermidine, curcumin, and melatonin by mechanism, trial quality, and fit. Her rule stays simple: measure what you can, match the dose to the need, and track outcomes with walking speed, grip strength, steps, and wearable sleep data over time, not once. &nbsp;Guest-at-a-Glance<a href="https://www.linkedin.com/in/urialonw/" rel="noopener noreferrer">💡 Name:&nbsp;Dr. Andrea Maier 💡 What she does:&nbsp;Professor in Medicine, Healthy Ageing and Dementia Research, and Director of the NUS Academy for Healthy Longevity 💡 Company:&nbsp;the National University of Singapore’s School of Medicine 💡 Noteworthy:&nbsp;She runs human trials on supplements and aging, audits label accuracy in the lab, and pushes a “measure first” approach using biomarkers, wearables, and simple strength tests. 💡 Where to find her:</a><a href="https://www.linkedin.com/in/andreamaierprof" rel="noopener noreferrer"> https://www.linkedin.com/in/andreamaierprof </a>💡 Guest Company Website:<a href="https://discovery.nus.edu.sg/19564-andrea-britta-maier" rel="noopener noreferrer"> https://discovery.nus.edu.sg/19564-andrea-britta-maier</a> &nbsp;&nbsp;Episode highlights:[00:00:00]: Introduction [00:01:02]: Overview of Evidence-Based Clinical Practice [00:02:16]: Multivitamins and Minerals: Usage and Population Trends [00:04:08]: Systematic Review Findings on Multivitamins and Cognitive Health [00:05:44]: Who Benefits Most from Multivitamin Supplementation [00:06:57]: Personalized Nutrition and the Case for Targeted Supplementation [00:08:21]: Ongoing Clinical Trials on Multivitamins and Biological Age [00:09:19]: Supplement Quality: Label Claims Versus Actual Content [00:12:14]: Navigating Supplement Quality and Consumer Guidance [00:14:53]: Novel Longevity Compounds: Alpha-Ketoglutarate [00:17:47]: Alpha-Ketoglutarate: Human Evidence and Population Focus [00:18:29]: Spermidine: Dietary Sources and Human Evidence [00:21:25]: Curcumin: Mechanisms, Evidence, and Target Populations [00:24:54]: Evaluating Supplements for Clinical Use [00:27:08]: Scientific Approach to Supplement Research [00:29:26]: The Role of Independent Research in Supplement Evaluation [00:32:37]: Melatonin: Sleep, Jet Lag, and Circadian Rhythm [00:37:25]: Practical Melatonin Use for Travel and Sleep Optimization [00:41:05]: Digital Biomarkers: Definition and Emerging Role [00:45:54]: Integrating Digital Biomarkers into Healthcare Practice [00:49:05]: Physical Function Tests: Grip Strength and Sit-to-Stand [00:59:48]: NAD Precursors: NMN, NR, and Human Trials [01:05:23]: NAD Testing: Current Landscape and Future Directions [01:07:24]: Final Takeaways and Closing Remarks&nbsp; &nbsp;&nbsp;For science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

Do Longevity Supplements Really Work?

In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Emeran Mayer, Executive Director at the UCLA Center for Neurobiology of Stress and Resilience and founder of Mayer Interconnected. They explore the science behind the gut-brain connection and its role in shaping health and longevity. Emeran explains how signals flow between the brain, gut, and microbiome, influencing everything from digestion to emotions. He breaks down how modern diets, especially ultra-processed foods, disrupt the natural balance between humans and gut microbes—a relationship refined over thousands of years. The conversation highlights why early life exposure to antibiotics can have lasting effects on microbiome resilience, and how lifestyle choices like diet and exercise remain powerful tools for supporting gut-brain health at any age. The discussion closes with a look toward the future of gut-brain science, including engineered probiotics and the promise of more targeted therapies. Emeran shares practical habits for better gut-brain health and cautions against quick-fix “biohacking,” encouraging a return to whole foods, movement, and mindful living. Guest-at-a-Glance💡 Name: Emeran Mayer 💡 What he does: Executive Director and Founder 💡 Company: Mayer Interconnected 💡 Noteworthy: Internationally recognized for his research on the gut-brain-microbiome connection, with deep expertise in how diet, emotion, and microbes shape lifelong health. 💡 Where to find him:<a href='https://www.linkedin.com/in/emeranmayer/'> https://www.linkedin.com/in/emeranmayer/</a>  Episode highlights: [00:00:00]: Introduction [00:01:04]: Background in Gut–Brain Science [00:03:04]: Early Influences and Career Path [00:06:07]: Focus on Irritable Bowel Syndrome [00:07:28]: Defining Irritable Bowel Syndrome [00:08:40]: Evolving Understanding and Treatment of IBS [00:10:22]: How the Gut and Brain Communicate [00:13:32]: Sensation, Pain, and Visceral Hypersensitivity [00:15:29]: Attention, Perception, and the Role of the Brain [00:17:06]: Regulation of Sensitivity and Interventions [00:18:25]: Bidirectional Brain–Gut System [00:19:40]: Hormonal Signaling from Gut to Brain [00:22:06]: Shared Biological Language of Gut, Brain, and Microbes [00:24:08]: Microbiome’s Role in Gut–Brain Communication [00:26:16]: Systems Biology and Complexity in Human Health [00:29:01]: Evolution, Symbiosis, and Environmental Mismatch [00:31:41]: Impact of Ultra-Processed Foods [00:36:16]: Restoring Gut–Brain Health Through Diet and Lifestyle [00:37:16]: Emotions and Their Effects on Gut Function [00:42:03]: Antibiotics, Microbiome Resilience, and Early Life Impact [00:46:25]: Aging, Microbiome, and Environmental Factors [00:49:33]: Future Directions in Gut–Brain Science [00:51:54]: Bioengineered Probiotics and Therapeutic Potential [00:56:00]: Rapid Fire: Habits, Foods, and Beliefs for Gut–Brain Health [01:00:31]: Closing Remarks and Takeaways We Appreciate You! As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast For science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Emeran Mayer, Executive Director at the UCLA Center for Neurobiology of Stress and Resilience and founder of Mayer Interconnected. They explore the science behind the gut-brain connection and its role in shaping health and longevity. Emeran explains how signals flow between the brain, gut, and microbiome, influencing everything from digestion to emotions. He breaks down how modern diets, especially ultra-processed foods, disrupt the natural balance between humans and gut microbes—a relationship refined over thousands of years. The conversation highlights why early life exposure to antibiotics can have lasting effects on microbiome resilience, and how lifestyle choices like diet and exercise remain powerful tools for supporting gut-brain health at any age. The discussion closes with a look toward the future of gut-brain science, including engineered probiotics and the promise of more targeted therapies. Emeran shares practical habits for better gut-brain health and cautions against quick-fix “biohacking,” encouraging a return to whole foods, movement, and mindful living. Guest-at-a-Glance 💡 Name: Emeran Mayer 💡 What he does: Executive Director and Founder 💡 Company: Mayer Interconnected 💡 Noteworthy: Internationally recognized for his research on the gut-brain-microbiome connection, with deep expertise in how diet, emotion, and microbes shape lifelong health. 💡 Where to find him: https://www.linkedin.com/in/emeranmayer/ Episode highlights: [00:00:00]: Introduction [00:01:04]: Background in Gut–Brain Science [00:03:04]: Early Influences and Career Path [00:06:07]: Focus on Irritable Bowel Syndrome [00:07:28]: Defining Irritable Bowel Syndrome [00:08:40]: Evolving Understanding and Treatment of IBS [00:10:22]: How the Gut and Brain Communicate [00:13:32]: Sensation, Pain, and Visceral Hypersensitivity [00:15:29]: Attention, Perception, and the Role of the Brain [00:17:06]: Regulation of Sensitivity and Interventions [00:18:25]: Bidirectional Brain–Gut System [00:19:40]: Hormonal Signaling from Gut to Brain [00:22:06]: Shared Biological Language of Gut, Brain, and Microbes [00:24:08]: Microbiome’s Role in Gut–Brain Communication [00:26:16]: Systems Biology and Complexity in Human Health [00:29:01]: Evolution, Symbiosis, and Environmental Mismatch [00:31:41]: Impact of Ultra-Processed Foods [00:36:16]: Restoring Gut–Brain Health Through Diet and Lifestyle [00:37:16]: Emotions and Their Effects on Gut Function [00:42:03]: Antibiotics, Microbiome Resilience, and Early Life Impact [00:46:25]: Aging, Microbiome, and Environmental Factors [00:49:33]: Future Directions in Gut–Brain Science [00:51:54]: Bioengineered Probiotics and Therapeutic Potential [00:56:00]: Rapid Fire: Habits, Foods, and Beliefs for Gut–Brain Health [01:00:31]: Closing Remarks and Takeaways We Appreciate You! As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast For science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Emeran Mayer, Executive Director at the UCLA Center for Neurobiology of Stress and Resilience and founder of Mayer Interconnected. They explore the science behind the gut-brain connection and its role in shaping health and longevity. Emeran explains how signals flow between the brain, gut, and microbiome, influencing everything from digestion to emotions. He breaks down how modern diets, especially ultra-processed foods, disrupt the natural balance between humans and gut microbes—a relationship refined over thousands of years. The conversation highlights why early life exposure to antibiotics can have lasting effects on microbiome resilience, and how lifestyle choices like diet and exercise remain powerful tools for supporting gut-brain health at any age. The discussion closes with a look toward the future of gut-brain science, including engineered probiotics and the promise of more targeted therapies. Emeran shares practical habits for better gut-brain health and cautions against quick-fix “biohacking,” encouraging a return to whole foods, movement, and mindful living. Guest-at-a-Glance💡 Name: Emeran Mayer 💡 What he does: Executive Director and Founder 💡 Company: Mayer Interconnected 💡 Noteworthy: Internationally recognized for his research on the gut-brain-microbiome connection, with deep expertise in how diet, emotion, and microbes shape lifelong health. 💡 Where to find him:<a href="https://www.linkedin.com/in/emeranmayer/" rel="noopener noreferrer"> https://www.linkedin.com/in/emeranmayer/</a> &nbsp;Episode highlights: [00:00:00]: Introduction [00:01:04]: Background in Gut–Brain Science [00:03:04]: Early Influences and Career Path [00:06:07]: Focus on Irritable Bowel Syndrome [00:07:28]: Defining Irritable Bowel Syndrome [00:08:40]: Evolving Understanding and Treatment of IBS [00:10:22]: How the Gut and Brain Communicate [00:13:32]: Sensation, Pain, and Visceral Hypersensitivity [00:15:29]: Attention, Perception, and the Role of the Brain [00:17:06]: Regulation of Sensitivity and Interventions [00:18:25]: Bidirectional Brain–Gut System [00:19:40]: Hormonal Signaling from Gut to Brain [00:22:06]: Shared Biological Language of Gut, Brain, and Microbes [00:24:08]: Microbiome’s Role in Gut–Brain Communication [00:26:16]: Systems Biology and Complexity in Human Health [00:29:01]: Evolution, Symbiosis, and Environmental Mismatch [00:31:41]: Impact of Ultra-Processed Foods [00:36:16]: Restoring Gut–Brain Health Through Diet and Lifestyle [00:37:16]: Emotions and Their Effects on Gut Function [00:42:03]: Antibiotics, Microbiome Resilience, and Early Life Impact [00:46:25]: Aging, Microbiome, and Environmental Factors [00:49:33]: Future Directions in Gut–Brain Science [00:51:54]: Bioengineered Probiotics and Therapeutic Potential [00:56:00]: Rapid Fire: Habits, Foods, and Beliefs for Gut–Brain Health [01:00:31]: Closing Remarks and Takeaways We Appreciate You! As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast For science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

The Gut–Brain Axis: A New Frontier in Longevity with Dr. Emeran Mayer

How and why do we age? Is aging reversible? These are some of the most critical questions in biology. Fortunately for us, researchers and scientists across the world strive to get some revolutionary answers. Our guest is one of them.Danica Chen is a Professor of Metabolic Biology, Nutritional Sciences & Toxicology at the University of California at Berkeley. Even though she originally intended to study international accounting, life had other plans, so she switched her major and went in another direction. Now, she's a member of Berkeley Stem Cell Center and a member of QB3 Consortium in Lifespan Extension, conducting research studies that aim to understand aging-associated conditions.Danica says the future of aging research is bright. "Using the knowledge we have learned from aging research and applying it to improve human health is what the aging field is trying to accomplish." In this episode of the Longevity by Design podcast, our hosts and Danica discuss the challenges in aging research, STEM cells' role in aging, and why the elderly are more prone to COVID. Tune in to the latest episode to find out more.To learn more and download InsideTracker's InnerAge eBook, visit: https://info.insidetracker.com/podcast

How and why do we age? Is aging reversible? These are some of the most critical questions in biology. Fortunately for us, researchers and scientists across the world strive to get some revolutionary answers. Our guest is one of them. Danica Chen is a Professor of Metabolic Biology, Nutritional Sciences & Toxicology at the University of California at Berkeley. Even though she originally intended to study international accounting, life had other plans, so she switched her major and went in another direction. Now, she's a member of Berkeley Stem Cell Center and a member of QB3 Consortium in Lifespan Extension, conducting research studies that aim to understand aging-associated conditions. Danica says the future of aging research is bright. "Using the knowledge we have learned from aging research and applying it to improve human health is what the aging field is trying to accomplish." In this episode of the Longevity by Design podcast, our hosts and Danica discuss the challenges in aging research, STEM cells' role in aging, and why the elderly are more prone to COVID. Tune in to the latest episode to find out more. To learn more and download InsideTracker's InnerAge eBook, visit: https://info.insidetracker.com/podcast

How and why do we age? Is aging reversible? These are some of the most critical questions in biology. Fortunately for us, researchers and scientists across the world strive to get some revolutionary answers. Our guest is one of them.Danica Chen is a Professor of Metabolic Biology, Nutritional Sciences &amp; Toxicology at the University of California at Berkeley. Even though she originally intended to study international accounting, life had other plans, so she switched her major and went in another direction. Now, she's a member of Berkeley Stem Cell Center and a member of QB3 Consortium in Lifespan Extension, conducting research studies that aim to understand aging-associated conditions.Danica says the future of aging research is bright. "Using the knowledge we have learned from aging research and applying it to improve human health is what the aging field is trying to accomplish." In this episode of the Longevity by Design podcast, our hosts and Danica discuss the challenges in aging research, STEM cells' role in aging, and why the elderly are more prone to COVID. Tune in to the latest episode to find out more.To learn more and download InsideTracker's InnerAge eBook, visit: https://info.insidetracker.com/podcast

What Aging Research Tells Us About Longevity with Danica Chen

Longevity by Design is your go-to podcast for science-backed conversations on living a longer, healthier life, with honesty about what the evidence actually shows. Hosted by a rotating panel of InsideTracker leaders, including Renee Deehan, SVP of Science and AI, this show dives into cutting-edge research, addresses bias and misinformation in health, and explores the intersection of preventive medicine, AI, and health equity.In each episode, our hosts sit down with leading researchers, clinicians, and policy experts to explore how we can live better, longer lives, and make sure that science reaches everyone, not just the wealthy well.&nbsp; Tune in to Longevity by Design and discover how to live a longer, healthier, and more vibrant life.

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Medicine

Health & Fitness

Longevity by Design is your go-to podcast for science-backed conversations on living a longer, healthier life, with honesty about what the evidence actually shows. Hosted by a rotating panel of InsideTracker leaders, including Renee Deehan, SVP of Science and AI, this show dives into cutting-edge research, addresses bias and misinformation in health, and explores the intersection of preventive medicine, AI, and health equity. In each episode, our hosts sit down with leading researchers, clinicians, and policy experts to explore how we can live better, longer lives, and make sure that science reaches everyone, not just the wealthy well.  Tune in to Longevity by Design and discover how to live a longer, healthier, and more vibrant life.

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