Buck interviews Dr. Dennis Hughes, a concierge physician with a special interest in lipidology. They discuss the complexities of cholesterol, the importance of understanding lipid profiles, and the role of various lipoproteins in cardiovascular health. Dr. Hughes emphasizes the need for modern medicine to move beyond outdated notions of 'good' and 'bad' cholesterol, advocating for a more nuanced understanding of lipid management. The discussion also covers key lab tests, the significance of apolipoprotein B, and the future of pharmacotherapy in lipid management.

Dr. Diogo Barardo, Director of Research and Development at Novos, joins Buck to discuss Novos' innovative approach to longevity supplements, unpacking the differences between biological and epigenetic aging and the impact of the Drug Age database. He details how Novos evaluates compounds for safety and efficacy, the unique ingredients in their flagship NovoScore, and the promising roles of lithium microdoses and NAD precursors. Their conversation also delves into the latest in longevity science, from the controversies around resveratrol to mitophagy's role in cellular health, the complexities of supplement dosages, and the potential of aging biomarkers and AI-driven research for consumer longevity solutions.

Learn more about Dr. Barardo and NOVOS: https://novoslabs.com/

Buck and Dr. Nathan Bryan delve into the pivotal role of nitric oxide in human physiology, with a particular focus on cardiovascular health and aging. Dr. Bryan breaks down the body's nitric oxide production processes, how everyday lifestyle choices impact its levels, and what happens when there's a deficiency. He also explores the surprising connection between oral hygiene and nitric oxide, the risks associated with proton pump inhibitors, and the promise of emerging products designed to boost nitric oxide levels. Additionally, Dr. Bryan addresses genetic factors such as MTHFR polymorphisms that can impact nitric oxide synthesis, shedding light on their broader implications for health and longevity.

Buck speaks to Dr. Torkil Færø, a Norwegian general practitioner, emergency physician, and seasoned traveler with Doctors Without Borders, to discuss the crucial relationship between stress, heart rate variability (HRV), and overall health. Dr. Færø delves into how HRV serves as a key indicator of our body's autonomic nervous system balance, showing how lifestyle factors, particularly chronic stress, can undermine well-being. He highlights practical strategies, from breathwork to dietary adjustments, aimed at optimizing HRV and promoting long-term health.

00:12 What is Heart Rate Variability?

05:34 The Normal Range of HRV

08:39 Contributing Factors that Impact Your HRV

23:18 Tactics to Improve HRV

Buck discusses the implications of mitochondrial dysfunction on aging, and the unique genetics of mitochondrial DNA. He also explores innovative approaches to enhance mitochondrial health, including gene therapy and the use of specific pharmaceuticals and supplements. Buck emphasizes the importance of understanding mitochondrial function in the context of health and longevity, while also addressing the potential challenges posed by medications like statins and conditions such as long COVID.

02:07 What are Mitochondria?

05:05 Mitochondrial Dysfunction and Aging

12:13 Mitochondrial Genetics and Inheritance

14:54 Innovative Approaches to Mitochondrial Health

17:58 Pharmaceuticals and Supplements for Mitochondrial Support

Buck delves into the pervasive issue of microplastics, exploring their sources, health risks, and potential strategies for detoxification and exposure reduction. He discusses how microplastics infiltrate our food, water, and air, and the alarming health implications they pose, including chronic inflammation and potential links to cancer, as well as practical steps to minimize exposure to microplastics in daily life.

In this episode of Longevity Junky, Buck and Nikki tackle one of the most contentious and polarizing areas of longevity, diet with Bio Layne founder Dr. Layne Norton.

Learn more about BioLayne and Dr. Layne Norton: https://biolayne.com/coach/layne-norton/

Full episode in video available on YouTube: https://www.youtube.com/channel/UCh6LlBjtOy7lldU7Ldjw0cw

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Buck introduces his brand new podcast, Longevity Junky.

In this episode of Longevity Junky, Buck and co-host Nikki Leigh sit down with renowned psychiatrist and brain disorder specialist, Dr. Daniel Amen, founder of Amen Clinics, to discuss groundbreaking brain imaging techniques like SPECT scans. Dr. Amen shares insights on diagnosing mental health issues through brain mapping and the role of brain health in overall longevity.

Dr. Susan Jackson discusses the concept of flow and its impact on quality of life and performance. Flow is an optimal psychological state where individuals are fully focused on a task and experience a loss of self-consciousness. It enhances the quality of our experience and can positively shape the quality of our lives. Flow can be experienced in various domains, including sports, creativity, and everyday activities. Mindfulness meditation can help access flow by improving focus and attention. The book 'Experiencing Flow' explores the relationship between mindfulness and flow and provides practical strategies for accessing flow in daily life.

00:13 The Definition of Flow

04:05 How Do We Have Flow?

08:25 Gettign In and Out of Flow

14:07 Mindfulness vs Flow