Longevity Roadmap

In this episode, Buck discusses gene editing and its potential implications for human health and longevity. He explains the basics of gene editing, including the structure of DNA and how genes are transcribed into proteins, then dives into the history and development of gene editing techniques, focusing on the game-changing CRISPR-Cas9 technology. He also explores the practical applications of gene editing, such as its use in treating sickle cell anemia and other genetic diseases, as well as the potential for human longevity, including targeting genes associated with aging and reversing epigenetic age.

Topics include:

00:25 Protein Intake for Longevity

12:40 Tips to Improve Sleep Quality

22:52 Is Robert F. Kennedy Jr. Controlled by a Worm

Topics include:

00:40 Is Weightloss Simply Calories In and Out?

07:10 Stem Cell Injections for NBA Players?

14:60 Statins for Lowering Cholesterol

23:19 The Impact of Nature and Nurture on Longevity

Buck Joffrey, MD discusses the concept of resilience with Stephen Sideroff, PhD. Topics include bouncing forward from stress and practical techniques to restore balance, nurture growth, and slow down the aging process.

01:35 Defining Resilience and the Ability to Adapt

08:21 Physical Balance and Mastery: Restoring Balance in the Nervous System

15:26 Self-Relationship: How It Changes Your Physiology

21:47 Resilience and Longevity

23:16 Emotion Balance and Mastery

02:00 Stem Cells 101

08:18 The Mechanism Behind

16:47 Stem Cells For Cancer

29:22 How Do Stem Cells Make You Live Longer?

46:25 FDA Indications

50:30 The Price

Buck discusses the concept of longevity clinics with the CEO of Humanaut.

Show Notes:

03:53 What Does Humanaut Do?

06:07 The Team Behind Humanaut

14:49 How Does the Program Work?

Buck Joffrey, MD reviews the literature on the topic of human attraction. Topics include the brain, perception of beauty, specific aspects of beauty, and sexual dimorphism.

Also included is a discussion on the role of human pheromones and attraction.

Show Notes:

01:20 Facial Attraction & Cues

08:30 Facial Symmetry

11:12 The Averageness of Facial Features

13:59 Clear and Unblemished Skin

15:44 Sexual Dimorphic Traits

22:23 Smell and Pheromone

Buck has a conversation with fellow physician, Dr. Matt Brill, on the topic of intermittent fasting. They bring up the American Heart Association study as well as associated studies of breakfast skippers to reconsider the issue of eight-hour time-restricted feeding. Also discussed are the topics of ideal, protein, intake, and full-body MRI.

Show Notes:

01:33 8 Hours Or Less Fasting Window = Higher Chance of Cardiovascular Disease?

04:58 Why the Study that Claimed the Correlation Was Wonky

08:02 Why There May Be Some Truth in the Studies

14:03 What to Do With Mixed Data and Opinions?

15:49 The Best Protein Intake?

22:32 Why Full Body MRI?

Buck Joffrey, MD discusses the basics of the keto diet with Amy Berger, a certified nutrition specialist. Topics include the definition of the diet, its health benefits and its role in the treatment of various disease processes including type 2 diabetes and Alzheimer's Disease.

Show Notes:

03:08 Why the Keto Diet?

04:15 How Does the Keto Diet Help You Lose Weight?

05:51 Other Benefits of the Keto Diet

09:14 How Does High Blood Sugar Result in Insulin Resistance?

11:44 What Defines a Keto Diet

16:13 Lifestyle VS Intervention

19:02 The Concern with High Cholesterol with the Keto Diet

24:11 Treating Alzheimer's with the Keto Diet

Buck Joffrey, MD reviews what is known about sexually transmitted cancers. Discussion includes HIV and Hepatitis but focuses on Human Papilloma Virus which Buck believes is grossly underappreciated by people and by physicians.

01:18 HIV

05:26 Hepatitis

09:20 HPV