Longevity Roadmap

Buck Joffrey, MD provides an introduction to the microbiome and discusses its importance. Topics also include prebiotics, probiotics, and postbiotics.

Buck Joffrey, MD, takes questions from the audience. Topics include human growth hormones, the potentially harmful effects of an MN, 40 Hz therapy, and visceral fat.

Show Notes:

00:47 Is It Fine That I Sleep Too Much?

08:08 The 40hz Gamma Frequency and How It Relates to Brain Health

13:28 The Anti-Aging Effects of Human Growth Hormone

20:31 Reconsideration of How to Fast

29:22 Potentially Harmful Effect of NMN

33:08 Visceral vs Subcutaneous Fat

Buck Joffrey, MD, discusses the fasting regimen with Dr. Valter Longo, PhD. Dr. Longo is a world, renowned researcher in longevity and the author of: The Longevity Diet.

Show Notes:

01:10 Types of Fasting

03:31 Why Fasting is Beneficial From a Cellular Level

07:00 Intermittent Fasting VS Fast Mimicking Diet

14:05 How Does Fasting Help Cancer Patients

20:37 What Is in the Fast Mimicking Diet

33:38 Pills and Supplements for Fasting Mimicking Diet

41:23 Time-Restricted Feeding Based on Circadian Rhythm

Buck Joffrey, MD interviews Robert Lufkin, MD about his book Lies I Taught in Medical School: And the Truths That Can Save Your Life Topics include metabolic syndrome, intermittent fasting, and various outdated information still used in mainstream medicine that may have deleterious effects on people's health.

Show Notes:

01:35 Dr. Lufkin's Personal Journey to Question the Medicine Establishment

04:14 When Did People Start to Take Metabolic Syndrome Seriously?

08:33 What Exactly is Metabolic Syndrome from a Physiological Standpoint?

10:21 The Balance Between Building and Breaking Down in the Metabolic System

14:41 Time-Restricted Feeding and Ketogenic Diet

28:31 The Role of Medications and Supplements

30:51 Lifestyle and Exercise as Intervention

Dr. Buck Joffrey, M.D. interviews, Dr. Nathan Price, PhD from Thorne about a new paradigm in medicine driven by data, technology, and self-empowerment.

Show Notes:

00:58 What Really is Healthspan?

05:06 Biological Age VS Chronological Age

07:41 The Factors that Determine Biological Aging

12:08 What Happens When You Artificially Suppress These Factors

16:58 What is Phenomics and how can it predict diseases?

24:21 How Can You Do Self Tests?

In this April Fools special, Buck answers the burning questions of his number one fan, Phil Ferragamo.

In this episode of Sapio, Dr. Buck Joffrey, MD addresses the recent American Heart Association study correlating intermittent fasting/time restricted, feeding to higher rates of cardiovascular death. Buck breaks down what we already know about the data behind intermittent fasting in both animals and in humans and tries to put the most recent study into context. He provides feedback on the study itself, including some suggestions on how to use this new information.

Show Notes:

02:01 Intermittent fasting vs caloric restriction

06:57 Why Intermittent Fasting Improves Metabolic Health

10:19 Intermittent fasting while maintaining a healthy diet

12:32 The study

19:35 What does this study mean to Buck?

Buck Joffrey, MD talks to Romie Mushtaq, MD regarding stress, cortisol levels and prevention strategies including meditation and anti-inflammatory diets.

Show Notes:

02:14 The definition of stress

13:16 Why does stress disrupt circadian rhythms and sleep

16:08 How do we treat stress?

21:23 Nootropics

24:39 Vagal nerve stimulator

28:34 Digital detox and meditation

33:02 Diet for stress

Buck Joffrey MD speaks to Justin Houman MD who is a urologist regarding the idea of aggressive testosterone treatment to decrease the risk of metabolic syndrome and therefore multiple other disease processes that are downstream. Other topics disgust include erectile dysfunction, early treatment with ED meds and the correlation with Alzheimer's disease.

Show Notes:

1:27 Is it true that the testosterone in men in general has gone down?

02:43 Common symptoms of low testosterone

05:15 Normal level of testosterone

07:19 Testosterone and metabolic syndrome

12:49 Testosterone replacement therapy and cancer

16:03 Downside of testosterone replacement therapy

19:18 Different options to supplement testosterone

29:03 What's on the horizon?

32:50 ED and cardiovascular diseases

38:35 Should all 40+ men be on daily Cialis?

40:43 Penile pump

Buck Joffrey, MD and Linda Tyler, PhD discuss the topic of plant-based only/Vegan diets. The conversation includes topics on inflammation and nutritional concerns.

Show Notes:

2:55 A plant-based diet for better health?

11:53 Balancing nutritions for the plant-based diet

20:39 Accessibility of the plant-based diet

22:30 Processed plant-based food