Luminous: A Podcast about Psychedelics from To The Best Of Our Knowledge

Psychedelic people are practicing at the very edge of anyone else’s comfort zone,” says psychologist Katherine MacLean, author of the psychedelic memoir “Midnight Water.” MacLean was a pioneering psychedelic researcher at Johns Hopkins, who then left her job to pursue her own unconventional psychedelic journey. She talks with Steve Paulson about her work as a psychedelic guide, her personal history with psychoactive substances, and why she reveres the Mexican healer Maria Sabina.

Original Air Date: August 30, 2024

Interviews In This Hour: 

Guests:
Katherine MacLean

For more from Luminous: ttbook.org/luminous

Erik Davis’ “Blotter” is really three books in one: It’s about the way LSD tabs were embedded in blotter paper so they wouldn’t be detected by the authorities; it’s also a deep dive into the psychedelic underground; and finally, it’s an art book — gorgeously illustrated, with lots of very trippy blotter art. Steve talks with Erik about the wildness of psychedelic experiences and whether they reveal a deeper dimension of consciousness.

Original Air Date: July 20, 2024

Guests:
Erik Davis

For more from Luminous: ttbook.org/luminous

Brian Muraresku makes the controversial argument that the famous Eleusinian Mysteries were fueled by a psychedelic wine. And he speculates that this secret ceremony, with its mind-altering drugs, became the Eucharist — the foundational event of early Christianity.

Original Air Date: May 04, 2024

Guests: 

Brian Muraresku

It’s remarkable how fast psychedelics have gone mainstream. Just look at how so many major universities are racing to set up their own psychedelic institutes. Psilocybin and MDMA are now considered the most promising treatments for depression and PTSD that we’ve had in decades. But this is not the first time psychoactive drugs were hailed as miracle cures. Heroin and cocaine were also once considered wonder drugs. Today, what’s so striking is how the public conversation about psychedelics ignores this deeper history of intoxicants.

British historian Mike Jay wants to challenge this narrative of psychedelic “exceptionalism.” In his book “Psychonauts: Drugs and the Making of the Modern Mind,” he digs into the 19th century’s rich history of psychoactive experiences — and tells the story of seminal figures like Humphry Davy, Sigmund Freud and William James – and lots of other people I’d never heard of.

Jay is also upfront about his own psychedelic experiences. He’s had plenty of them. And he believes the scientists and doctors who study psychedelics should talk more openly about their own mind-altering experiences — which is definitely not the case for most of them.

Original Air Date: January 27, 2024

Guests:

Mike Jay

Further Reading:

"Psychonauts Drugs and the Making of the Modern Mind"—Nautilus: "Why Scientists Need to Get High"

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For all the talk about how psychedelics might transform psychiatric care, there's still a fascinating question at the heart of psychedelic science. Is it the mind-blowing experience that fundamentally changes a person’s outlook on life? Or is it the powerful molecules that rewire the brain?

Check out more from the series at ttbook.org/luminous.

Original Air Date: December 16, 2023

Interviews In This Hour:

Does psychedelic therapy need the trip? — Will psychedelics replace antidepressants? — Spiritual warriors in the psychedelic underground

Guests:

David Olson, Charles Raison, Rachel Harris

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Some people dabble in psychedelics, others are more serious psychonauts. And then there’s Chris Bache. Over the course of 20 years, he had 73 high-dose LSD experiences — doses so high that the human body couldn’t tolerate anything more. For Bache, who was a religion professor, these were journeys into deeper dimensions of reality. These were grueling experiences — at times terrifying and other times ecstatic. He believes he transcended every aspect of personal identity and ultimately encountered the Divine – what he calls “the infinite creative intelligence of the universe.” And he ended up in a really interesting place, wondering if it’s possible to have too much transcendence.

It’s an extraordinary story – one that Bache later wrote about in his book “LSD and the Mind of the Universe." In this conversation, he reflects on the years when he was going on these intense LSD journeys, which he did in secret, on weekends, while carrying on his work as a college professor during the week.

Just to be clear, what Chris Bache did was extremely risky. His story is fascinating, but it’s not something anyone else should do.

Original Air Date: November 18, 2023

For more from the series, visit ttbook.org/luminous

It’s easy to get caught up in the hype about how psychedelics might revolutionize the treatment of mental illness. But there are also lots of ethical concerns. And probably none are so troubling as the charges of exploitation and cultural appropriation. The fact is, the knowledge about many psychedelics — like magic mushrooms and ayahuasca — comes from the sacred ceremonies of Indigenous cultures. But over the past century, Western scientists and pharmaceutical companies have been going into these cultures, collecting plants and synthesizing their chemical compounds.

Even if science is all about building on the knowledge of earlier discoveries, what is the psychedelic industry's ethical responsibility? Can psychedelics be decolonized?

Original Air Date: October 21, 2023

Interviews In This Hour:

The Tragic Story of Maria Sabina's Sacred Mushrooms — Empowering Indigenous voices in the psychedelic industry — Bioprospecting for psychedelics: How Pharma hunted for Indigenous plant medicines — Spirit Medicine: Yuria Celidwen's vision for an ethical psychedelics

Guests:

Michael Pollan, Dennis McKenna, Erika Dyck, Katherine MacLean, Sutton King, Rachel Fernandez, Lucas Richert, Yuria Celidwen

For more from this series, visit ttbook.org/luminous.

Psychedelics have a unique capacity to open up the mind so that everything feels fresh and full of possibilities. Especially as you get older, it can be easy to get stuck in a rut — but under a psychedelic, the brain can become more plastic. This time period, though, is limited - it might last just a few days, or a few weeks. So it’s really important to understand this “critical period” when our minds are so open — and also so vulnerable.

These “critical periods” are what Gul Dolen has been studying for years. She’s a neuroscientist at Johns Hopkins that has done some groundbreaking investigation of the “critical periods” of psychedelics, including studies that involve giving MDMA — also known as “Molly” in some circles — to octopuses.

She’s also challenging a lot of the scientific work that’s been done on psychedelics — she has serious doubts about the value of neuroimaging, or even a concept like the “default mode network.” If you heard our last Luminous episode on the neuroscience of psychedelics, you’ll want to listen to this interview.

For more from Luminous, visit our website at ttbook.org/luminous

Original Air Date: August 12, 2023

Interviews In This Hour:

Guests:

Gul Dolen

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Can neuroscience explain what happens to the brain on psychedelics? And even if we map the brain while it’s tripping, does that tell us why these experiences can be so transformative? 

We’ll talk with some of the pioneers in psychedelic research — from Amanda Feilding’s boundary-busting work to Robin Carhart-Harris’ theory of the "entropic brain." Also, renowned neuroscientist Christof Koch goes down the rabbit hole on 5-MeO-DMT, also known as toad venom.  

Original Air Date: July 15, 2023

Interviews In This Hour:

Exploring consciousness on toad venom — The godmother of the European psychedelic revival — How therapeutic psilocybin could help heal long-buried trauma — Magic mushrooms and the 'entropic brain'

Guests:

Christof Koch, Amanda Feilding, David Nutt, Robin Carhart-Harris

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Just a few years ago, it was pretty unusual to hear big-time celebrities talk about their own psychedelic experiences. But that stigma is starting to fade thanks to people like the rock star and music icon Melissa Etheridge. 

For her, this psychedelic renaissance has gotten very personal. Three years ago, her son Beckett died at the age of 21 from an opioid drug overdose. When Etheridge heard that clinical trials with psilocybin were showing real promise for treating addiction, she became an outspoken advocate for psychedelic therapy. And she started her own nonprofit organization, the Etheridge Foundation, to support scientific research into the causes and treatments for opioid addiction. 

Melissa Etheridge recently came through Madison, Wisconsin for an evening concert. Earlier that day, she stopped by the Usona Institute — which is running its own clinical trials on psilocybin and 5-MeO-DMT — where she sat down with Steve for a short interview. She talked about the death of her son, and her own life-changing experiences with ayahuasca. She explains why she’s fascinated by psychedelics as both a path for spiritual exploration and a source of creativity.

Original Air Date: July 08, 2023