Sam Harris speaks with Roland Griffiths about the current state of research on psychedelics. They discuss the historical prohibition against their use; the clinical and scientific promise of psilocybin, mescaline, LSD, DMT, MDMA, and other compounds; the risks associated with these drugs; the role of "set and setting"; the differences between psychedelics and drugs of abuse; MDMA and neurotoxicity; experiences of unity, sacredness, love, and truth; the long-term consequences of psychedelic experiences; synthetic vs natural drugs; the prospects of devising new psychedelics; microdosing; research on psilocybin and long-term meditators; the experience of encountering other apparent beings; psilocybin treatment of addiction; and other topics. In his Afterword, Sam discusses his experience on a large dose of psilocybin—his first psychedelic experience in 25 years.

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Sam Harris speaks with Lynn Novick about her four-part documentary "College Behind Bars." The film follows the progress of students in the Bard Prison Initiative (BPI) as they pursue their undergraduate degrees. Sam and Lynn are joined by Jule Hall, a BPI graduate who served a 22-year sentence and is now working for the Ford Foundation.

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Sam Harris speaks with Yasmine Mohammed about her book "Unveiled: How Western Liberals Empower Radical Islam." They discuss her family background and indoctrination into conservative Islam, the double standard that Western liberals use when thinking about women in the Muslim community, the state of feminism in general, honor violence, the validity of criticizing other cultures, and many other topics.

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Sam Harris speaks with Richard Dawkins. They discuss the strangeness of the "gene's-eye view" of the world, the limits of Darwinian thinking when applied to human life, the concept of the extended phenotype, ideologies as meme complexes, whether consciousness might be an epiphenomenon, psychedelics, meditation, and other topics.

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Sam Harris speaks with Bari Weiss about her book "How to Fight anti-Semitism." They discuss the three different strands of anti-Semitism (rightwing, leftwing, and Islamic), the Tree of Life shooting in Pittsburgh, the difference between anti-Semitism and other forms of racism, "Great Replacement Theory," the populist response to globalization, the history of anti-Semitism in the U.S., criticisms of Israel, the fate of Jews in Western Europe, and other topics.

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Sam Harris speaks with Andrew Marantz about his book "Antisocial: Online Extremists, Techno-Utopians, and the Hijacking of the American Conversation." They discuss the effect of social media on politics, the distinction between publishers and platforms, the problem of guilt by association, getting too close to interview subjects, the confusing nature of troll culture, the notion of "dog whistles," how to respond to the current reality of racism, and other topics.

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Sam Harris speaks with Megan Phelps-Roper about her book "Unfollow: A Memoir of Loving and Leaving the Westboro Baptist Church."

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Sam Harris speaks with Andrew McAfee about the history of human progress and the modern uncoupling of our prosperity from resource consumption. They discuss the pitfalls and hidden virtues of capitalism, technological progress, environmental policy, the future of the developing world, and other topics.

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Sam Harris speaks with Kathleen Belew about the white power movement in the United States. They discuss white supremacy, white nationalism, white separatism, the militia movement, "The Turner Diaries," the connection between the white power movement and war, the significance of Ruby Ridge and Waco, the Christian Identity movement, the significance of "leaderless resistance," the failures of the justice system in prosecuting white power crimes, and other topics.

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Sam Harris speaks with Barbara Tversky about how our senses of space and motion underlie our capacity for thought. They discuss the evolution of mind prior to language, the importance of imitation and gesture, the sensory and motor homunculi, the information communicated by motion, the role of "mirror neurons," sense of direction, natural and unnatural categories, cognitive trade-offs, and other topics.

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