In this episode of The Good GP, host Dr Sean Stevens is joined by Dr Terri-Lynne South live from the GP25 Conference, to deliver an overview of obesity management, with a specific focus on the use of GLP-1 and GIP dual incretin therapies in general practice.

Dr Terri-Lynne South outlines the current Therapeutic Goods Administration (TGA)-approved indications for these treatments in Australia. These include use in patients with type 2 diabetes, overweight with complications, chronic kidney disease and type 2 diabetes, obesity with obstructive sleep apnoea, and secondary prevention of cardiovascular disease. Noting that this field is rapidly evolving, with recent changes in indications and ongoing international developments.

Addressing the importance of setting realistic patient expectations regarding weight loss outcomes and the duration of treatment, emphasising that clinical obesity is a chronic, complex condition requiring long-term management. Evidence shows that weight loss achieved with GLP-1 therapies can be maintained over four years if the patient remains adherent, while early discontinuation often leads to significant weight regain.

Practical strategies for managing common side effects, mainly gastrointestinal symptoms like nausea and constipation, are described in detail. Dr Terri-Lynne South provides useful tips for patients, including hydration, dietary modifications, and mindfulness around portion size and satiety cues. 

The importance of a multidisciplinary approach is reinforced, including psychological assessment (screening for eating disorders, depression, anxiety, and complications like sleep apnoea), dietitian involvement, and possible referral to exercise physiology and psychology services where also clinically indicated.

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