June 16, 2025

Meta Oakleys, Golden Retriever Maxing, Suits in Airports | John Jumper, Christian Garrett, Aaron Frank, Joseph Cass

2 hours 40 minutes

(04:18) - Timeline Reactions

(27:43) - John Jumper, an American computational biologist and senior staff research scientist at DeepMind, is renowned for leading the development of AlphaFold, an AI system that predicts protein structures from amino acid sequences. In the conversation, he discusses how AlphaFold has revolutionized the field by transforming a process that traditionally took years and significant resources into one that can be completed in minutes, thereby accelerating scientific research and applications in drug development and understanding biological processes. He also highlights the challenges faced during AlphaFold's development, including initial misconceptions about the problem's nature and the necessity of adopting a data-driven, supervised learning approach to achieve success.

(01:00:07) - Christian Garrett, a partner at 137 Ventures, discussed the challenges facing $1 to $10 billion horizontal software companies, noting their vulnerability to commoditization and the impact of AI on growth. He emphasized the importance of sustainable competitive advantages and multi-product strategies for long-term success. Garrett also highlighted the trend of high-growth private companies remaining private longer, creating a new category of semi-liquid assets with significant implications for venture capital and liquidity dynamics.

(01:34:06) - Aaron Frank, a Venture Partner at Lightspeed Venture Partners, co-founded Final, Inc., a credit card company acquired by Goldman Sachs in 2018, which became the foundation for the Apple Card. In the conversation, he discusses the evolution of fintech, highlighting the challenges of building financial products, the impact of stablecoins on the financial system, and the role of AI in enhancing fintech services.

(02:02:50) - Joseph Cass, Senior Director of Market Outreach for EMEA at S&P Global Ratings, discusses his role in engaging with major buy-side investors and how he initiated the "Leaders" podcast to facilitate conversations with senior figures in finance. He shares experiences from interviews with notable financiers like Ken Griffin and Ray Dalio, highlighting their insights and personal stories. Additionally, Cass touches on the evolving focus of investors from ESG considerations to broader sustainability topics.

(02:19:29) - Timeline Reactions

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