Mikkipedia

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This week on the podcast, Mikki speaks to Dr. James Dorling, a researcher whose work challenges many of the traditional assumptions around energy expenditure, weight loss, and personalised nutrition.

Dr. Dorling’s research spans multiple large-scale studies, including the E-MECHANIC trial, which revealed that traditional metabolic equations often overestimate energy burn—particularly in certain populations. His work also highlights differences in how men and women, and people of different ethnicities, respond to exercise in terms of energy expenditure, raising important questions about the accuracy of fitness trackers and calorie calculations.

In this conversation, Mikki and James explore why some people seem to hit a weight-loss plateau despite regular exercise, how compensatory mechanisms might be working against fat loss goals, and what practical strategies can help break through these barriers. They also dive into findings from the CALERIE™ study, where unexpected predictors of weight loss—like sexual satisfaction—emerged, and discuss the potential for machine learning to improve personalised weight-loss strategies.

Beyond metabolism, they tackle the hype around DNA-based nutrition plans and the reality of individual variability in weight loss outcomes.

Dr. James Dorling is a lecturer in Human Nutrition at the University of Glasgow, with a research focus on the impact of nutrition and physical activity interventions on obesity, metabolic health, and aging biomarkers. His work explores appetite regulation, eating behaviours, and how these factors change in response to lifestyle interventions.

Dr. Dorling completed his undergraduate degree in Sport and Exercise Science at the University of Bath before earning his PhD from Loughborough University, where he investigated the effects of acute exercise and obesity-related genetic factors on appetite and appetite-related hormones. He then continued his research as a postdoctoral fellow at the Pennington Biomedical Research Center, studying the influence of calorie restriction and exercise on weight regulation, aging, and metabolic adaptations.

Dr. Dorling's work has been featured in leading scientific publications and podcasts, where he discusses the intersection of metabolism, exercise, and behaviour change. His research challenges conventional wisdom around weight loss and aims to refine personalised strategies for improving health outcomes.

For more on his work, visit his profile at the University of Glasgow: https://www.gla.ac.uk/schools/medicine/staff/jamesdorling/ 

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This week on the podcast Mikki speaks to returning guest Dr Tony Botaugy, for a robust discussion around fuelling for different athletes and different contexts. They also discuss low energy availability and the prevalence of relative energy deficiency in sport. Mikki and Tony don’t always agree, but they do agree that context is everything when making recommendations.

Tony is a strength coach and an exercise physiologist based in Sydney, Australia. His undergraduate degree was in Human Movement (ACU) and he holds a PhD in Exercise and Sports Science from Charles Darwin University in far north Australia.

In his coaching career that has spanned closed to 30 years, he has written over 70,000 training programs, across a wide range of populations, including the general public, athletes, Olympians (2004, 2008, 2012, 2016), special populations and those needing rehabilitation from injuries. 

Tony has been involved in education since 1999, having held various educational positions at several universities in exercise science, physiotherapy, and personal training. His own educational programs for personal trainers, allied health professionals and the general public have been running for since 2002, which have now moved to an online platform since Covid.

Previously Tony has been an Adjunct Associate Lecturer at the University of the Sunshine Coast, a lecturer at the Australian Fitness Network, AIF, the Australian Catholic University (Schools of Exercise Science and Physiotherapy), NetFit New Zealand and New Zealand Weightlifting.

Tony has also been an editorial board member for The University of the Sunshine Coast's Fitness Research department and an editor for the Journal of Fitness Research, a member of the Australian Institute of Fitness Personal Training Advisory Panel and has sat on the expert advisory panel for Fitness Australia. Over the past three decades Tony has written hundreds of health and fitness related articles and was the recipient of the 2004 Australian Fitness Industry’s Author of the Year Award. 

Find Tony here: https://www.tonyboutagy.com/pages/about-tony

IG: https://www.instagram.com/tonyboutagy/?hl=en 

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Today on the podcast, Mikki speaks to Dr. Dom D’Agostino, a leading researcher in metabolic health, ketogenic diets, and performance optimization. Dom has been at the forefront of exploring how nutrition—particularly low-carb and ketogenic strategies—impacts brain health, endurance performance, cancer metabolism, and longevity.

In this episode, he and Mikki dive into two major topics that have been gaining traction in the health and nutrition space: allulose as a metabolic sweetener and the latest research on the ketogenic diet’s effects on lipids, gut health, and glucose metabolism.

They begin by unpacking allulose, a rare sugar that’s rapidly growing in popularity within the low-carb and metabolic health community. Dom has conducted extensive n=1 experiments on this sweetener and has shared his insights widely on social media. He explains how allulose differs from traditional sweeteners, its impact on blood sugar, insulin, and GLP-1, and whether it could be a game-changer for metabolic health. They also discuss how the FDA’s labeling decision influences consumer perception and what role allulose might play in future dietary strategies.

The conversation then shifts to the ketogenic diet, exploring a recent study that examined its effects on metabolic health, gut microbiome, and cardiovascular markers. Some of the findings—such as increased ApoB and transient inflammation—have sparked debate, and Dom provides his perspective on what these results actually mean. He and Mikki also discuss the implications of gut microbiome shifts, the potential concerns around glucose tolerance, and how to fine-tune a ketogenic approach for long-term health.

For anyone interested in the cutting edge of metabolic science—whether it’s the role of emerging sweeteners or the nuances of ketogenic diets—this episode is packed with valuable insights.

Dr. Dominic D’Agostino is a leading researcher in the fields of metabolic health, ketogenic nutrition, and performance science. As an Associate Professor at the University of South Florida in the Department of Molecular Pharmacology and Physiology, his work focuses on the neuroprotective and therapeutic applications of ketogenic diets, exogenous ketones, and metabolic therapies for conditions such as epilepsy, cancer, and neurodegenerative diseases.

Dr. D’Agostino’s research spans human performance, space medicine, and metabolic resilience, with collaborations extending to NASA, the Department of Defense, and leading medical institutions. His work has explored how ketogenic and fasting-based strategies can enhance physical and cognitive function under extreme conditions, from deep-sea diving to spaceflight.

In addition to his academic and research work, he is widely recognized for his expertise in low-carb and ketogenic science, frequently sharing insights on his podcast appearances, social media, and public talks. He has conducted extensive n=1 experiments on metabolic biomarkers, dietary interventions, and the effects of ketones and alternative sweeteners like allulose, helping to bridge the gap between scientific research and real-world application.

Dr. D’Agostino is also on the editorial board of multiple scientific journals, has published extensively in peer-reviewed literature, and is a sought-after speaker in the areas of metabolic health, longevity, and human optimization. His work continues to push the boundaries of what’s possible in nutrition science and metabolic therapies

Metabolic link https://podcasts.apple.com/au/podcast/the-metabolic-link/id1666125722

Metabolic Health Summit https://metabolichealthsummit.com/

Dom’s website https://www.drdominicdagostino.com/

Ketogenic diet and gut health https://www.sciencedirect.com/science/article/pii/S2666379124003811?via%3Dihub 

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Contact Mikki:
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Curranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to www.curranz.co.nz  or www.curranz.co.uk to order yours

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Today on the podcast, Mikki speaks to Kristi Storoschuk, a passionate researcher, science communicator, and PhD candidate at Queen’s University. Kristi’s research focuses on exercise physiology, metabolic health, and the fascinating world of nutrient-exercise timing.

In this episode, we dive into topics like mitochondrial biogenesis, behind fasted versus fed training, and Kristi’s broader research interests in improving metabolic health and blood sugar regulation. Kristi also shares her insights on the practical applications of her work, touching on how science can inform our day-to-day choices in nutrition and exercise.

Whether you're an athlete, a coach, or simply interested in optimising your health, this conversation is packed with actionable advice and thought-provoking science. 

Kristi Storoschuk is a researcher, science communicator, and PhD candidate in the Muscle Physiology Lab at Queen’s University in Kingston, Ontario. Her academic work focuses on exercise physiology, metabolic health, and nutrient-exercise timing, with a particular interest in how these factors influence mitochondrial biogenesis and blood sugar regulation.

Kristi’s passion for health and nutrition stems from her early experiences working in her family’s health food store. This foundation inspired her journey into research, where she bridges cutting-edge science with practical strategies to improve metabolic health and promote healthy aging.

In addition to her academic pursuits, Kristi has over three years of experience writing on topics such as ketogenic diets, fasting, and metabolic therapies. She has contributed to platforms like Paleo Magazine, CrossFit, and the Zero Longevity app, and serves on the Scientific Advisory Board at Keto Kind. She is also a sought-after speaker and science communicator, known for her ability to make complex topics accessible and engaging.

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https://gretchenrubin.com/quiz/the-four-tendencies-quiz/

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This week on the podcast, Mikki speaks with Dr. Paul Laursen, renowned sports scientist, endurance coach, and co-founder of Athletica AI. Dr. Laursen has been at the forefront of endurance research, particularly in exploring the evolving role of carbohydrates in fueling elite and age-group athletes. Together, they dive into the science and practical application of high-carbohydrate intake during endurance events, including the evidence behind consuming up to 120 grams per hour, how this practice became a gold standard for elites, and the factors that influence an athlete's ability to efficiently utilize such large amounts.

Dr. Laursen sheds light on the physiological impacts of extreme carbohydrate fueling, addressing its potential benefits, limits, and risks, including GI distress, inflammation, and even its connection to overtraining or heart health in some cases. He shares insights into why age-group athletes often struggle when emulating elite practices and offers practical strategies for aligning carbohydrate intake with individual needs and training loads.

Mikki and Dr. Laursen also discuss the misconceptions around low-carb approaches in endurance sports, hybrid fueling strategies that combine low- and high-carb periods, and the importance of balancing performance with long-term health. With his years of coaching and research, Dr. Laursen shares invaluable advice for endurance athletes looking to optimize their fueling strategies, whether they're chasing personal bests or aiming for sustainable performance. This is a must-listen for anyone curious about the future of endurance nutrition and how to fuel smarter.

Dr. Paul Laursen is a world-renowned sports scientist, endurance coach, and co-founder of Athletica AI, an innovative platform leveraging artificial intelligence to optimize endurance training. With a PhD in Exercise Physiology and years of research experience, Dr. Laursen has published extensively on topics including high-intensity interval training (HIIT), endurance performance, and sports nutrition. His work bridges the gap between cutting-edge science and practical application for athletes at all levels.

Dr. Laursen has worked with elite athletes across disciplines, helping them achieve peak performance through personalized training and nutrition strategies. He’s also a passionate educator, co-authoring the influential book The Science and Application of High-Intensity Interval Training and contributing to the evolution of endurance sports practices. Known for his holistic approach, Dr. Laursen focuses on the interplay between fueling, recovery, and overall athlete health, making him a leading voice in the field of endurance sports.

When he’s not advancing endurance science, Dr. Laursen is often found testing his own limits in the field as an endurance athlete, embodying the principles he teaches. His unique blend of scientific expertise and real-world experience continues to shape the way athletes train, fuel, and perform

https://podcast.mikkiwilliden.com/46

https://podcast.mikkiwilliden.com/3 

https://podcasts.apple.com/ca/podcast/how-to-fuel-for-health/id1490521721?i=1000675196238 

https://www.paullaursen.com/ 

https://athletica.ai/ 

https://www.mikkiwilliden.com/unlocking-metabolic-mastery-2025 

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Contact Mikki:
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https://pmc.ncbi.nlm.nih.gov/articles/PMC11703406/

https://pmc.ncbi.nlm.nih.gov/articles/PMC7871530/

Contact Mikki:
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NZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at www.calocurb.co.nz
Save 20% on all Nuzest Products WORLDWIDE with the code MIKKI at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.com
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