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Nick talks to anesthesiologist & neuroscientist Dr. Alex Proekt, who runs a lab at the University of Pennsylvania, about altered states of consciousness. They discuss: NREM & REM sleep, anesthesia & anesthetic drugs like propofol; coma & vegetative states; sleeping pills like Ambien; the relationship between consciousness & the underlying brain dynamics; how ketamine differs from other anesthetics & what it does to brain activity; AI & ChatGPT.

*Not medical advice.

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Nick talks to Jay Bhattacharya, MD, PhD, who is a professor of medicine & economics at Stanford University. They discuss various aspects of the COVID pandemic, such as: how infectious, transmissible, and deadly SARS-CoV-2 is; mRNA vaccines, how well they stop transmission vs. severe COVID, and whether they can induce negative side effects such as myocarditis; how well masks really work; Jay's inclusion in the "TwitterFiles" and the suppression of speech on social media; what he thinks of Elon Musk after meeting him; his thoughts on the future of public health governance in the US.

Related episodes:

• M&M #61: Public Health, Pandemics, Epidemiology, SARS-CoV-2 & COVID Public Policy | Martin Kulldorff

*This content is never meant to serve as medical advice

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• AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.
• OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.
• SiPhox Health: Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off.
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Nick talks to Dr. Sergiu Pasca, a developmental neuroscientist and professor at Stanford University. They discuss topics related to human brain development, the origins of neuropsychiatric disease like autism & schizophrenia, new technologies for studying brain development, stem cells, and recent experiments from Dr. Pasca'a lab utilizing brain "organoids," "assembloids," and human-animal transplantations.

*Not medical advice.

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• OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.
• SiPhox Health: Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off.
• KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)
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Nick talks to computational neuroscientist Dr. Zach Mainen, a neuroscientist and director of the Champalimaud Neuroscience Programme at the Centre of the Unknown in Lisbon, Portugal. His lab studies the neuroscience of decision making, neuromodulation & behavior using both experimental and computational approaches. 

They discuss: what kinds of things animal brains are actually computing, and to what extent we can think about brains like computers; the difference between neurotransmitters and neuromodulators in the brain, including some discussion of what specific neuromodulators like dopamine and serotonin do in the brain; and we also discussed some of the research his lab is starting to do on serotonergic psychedelics, including how he thinks about whether the subjective effects of psychedelics are likely to be important for the therapeutic and neuroplastic effects.

*Not medical advice.

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• OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.
• SiPhox Health: Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off.
• KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)
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Nick talks to mathematical biologist Dr. Alex Washburne about the origins of the SARS-CoV-2 virus.

*Not medical advice.

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• OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.
• SiPhox Health: Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off.
• KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)
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Nick talks to experimental psychologist Dr. Harriet de Wit, a professor at the University of Chicago whose lab studies the behavioral effects of psychoactive drugs on humans. They discuss: the effects of MDMA on emotional perception and touch sensation; the effects of microdosing LSD; THC's impact on memory.

*Not medical advice.

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Health Products by M&M Partners:

• AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.
• OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.
• SiPhox Health: Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off.
• KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)
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Nick talks to biological anthropologist & neuroscientist Dr. Terrence Deacon, who is a professor of biological anthropologist at UC-Berkeley and a leading thinker on the evolution of language, consciousness and human cognition. They discuss: how end-directed systems, such as life, can emerge from non-life; how complexity evolves once life originates; the origins of sentience and a sense of self; the evolution of the nervous system and consciousness; information, value, and "aboutness" in the universe; and more.

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• OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.
• SiPhox Health: Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off.
• KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)
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Nick talks to neuroscientist Dr. Kent Berridge, a professor of psychology & neuroscience at the University of Michigan. They discuss: the neurobiology of the brain processes rewards and generates pleasure & motivation; the difference between "liking" and "wanting"; hunger and whether food addiction is similar to drug addiction; emotion and consciousness; and more.

*This content is never meant to serve as medical advice.

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Health Products by M&M Partners:

• AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.
• OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.
• SiPhox Health: Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off.
• KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)
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Nick talks to Dr. Amir Englund, a psychopharmacologist at the Institute of Psychiatry, Psychology & Neuroscience at King's College, London. Dr. Englund's research focuses on the effects of cannabis, medical marijuana and specific cannabinoids (e.g. THC, CBD, THCV) on human cognitive function. They discuss topics including: what is the addiction liability of marijuana? What are the acute & chronic cognitive effects of THC, including how it impacts memory & executive function; how the effects of THC can be modulated by cannabinoids like CBD & THCV; the relationship between marijuana & THC and psychosis (e.g. schizophrenia); and more.

*Not medical advice

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Health Products by M&M Partners:

• AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.
• OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.
• SiPhox Health: Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off.
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Nick talks to molecular physiologist Dr. Dudley Lamming, a professor of medicine at the University of Wisconsin-Madison whose lab studies how the body responds to the nutrient and calorie content of food. We discuss: how the protein and amino acid composition of food impacts metabolic health & aging; branched chain amino acids & disease; sex differences between males & females in how diet affects health; fasting, calorie restriction & fasting; and more.

*Not medical advice.

Support the show

Health Products by M&M Partners:

• AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.
• OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.
• SiPhox Health: Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off.
• KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)
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For all the ways you can support my efforts