Metabolic Mind

By Bret Scher

Metabolic Mind is working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. Metabolic interventions like ketogenic therapy are b... more

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The podcast currently has 251 episodes available.

Best of Metabolic Mind

The most played episodes among Podcast App listeners.

Number 1: BITESIZE: Dr. Explains: It’s Not the Fat, It’s Not the Processing, It’s THIS
Every day, we make choices about what to eat. But how often do we realize how deeply these choices affect both our physical and mental health? Today, an estimated 93% of adults in America are showing signs of poor metabolic health, which is a major contributor to many chronic conditions like heart disease, type 2 diabetes, obesity, and many psychiatric disorders. The good news is that more people are recognizing the powerful role food plays in metabolic health. But with all the conversations about what to do next, like limiting ultra-processed foods or reconsidering saturated fat guidelines, are we overlooking one of the most impactful steps we can take? In this video, cardiologist Dr. Bret Scher explores why focusing on reducing or eliminating ultra‑processed carbohydrates may be one of the most powerful ways to address the chronic disease epidemic. Dr. Scher breaks down:What refined carbohydrates are and how they can wreck metabolic healthHow constant glucose spikes and crashes can fuel hunger, fatigue, and poor moodWhat insulin resistance is, how it develops, common symptoms, and how it contributes to chronic diseasesHow visceral fat packs on and contributes to chronic diseaseWhy we can’t stop eating refined carbohydratesWhy low fat and high carb diets don’t work for most peopleWhat the science says about cutting processed carbsPractical advice on how to eat to improve metabolic health 🎙️ Take the Metabolic Mind Podcast Listener Survey for a chance to win! We’d love your feedback on what you’re enjoying, what you’d like to hear more of, and how we can make the podcast even more helpful. Complete the quick survey by September 15 for a chance to win a Metabolic Mind giveaway bundle featuring a Keto-Mojo meter, books from Dr. Chris Palmer and Dr. Georgia Ede, Metabolic Mind swag, and more. Winners will be notified September 18. Take the survey here: https://metmind.co/survey-listeners No purchase necessary. Open to U.S. residents and international participants 18+. Ends 9/15/26 at 11:59 PM PT. Void where prohibited. Expert Featured: Dr. Bret ScherBaszucki Group Medical Directorhttps://x.com/bschermd Free CME Clinician Trainings: Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein and Dr. Bret Scher with more coming soon. Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-yt Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
August 30, 20267min
Number 2: Do We Really Eat Too Much Protein?
Do most people really need to eat less protein to live longer? In this episode of Metabolic Mind, Dr. Bret Scher responds to a new review getting attention for the claim that protein restriction may extend lifespan, and explains why that message can be misleading for older adults, active people, and anyone focused on metabolic health. Dr. Scher walks through the biology behind the headlines, including mTOR, FGF21, animal research, and the limits of applying rodent data directly to humans. He also explains why adequate protein becomes more important with age, especially for preserving muscle, reducing frailty risk, supporting insulin sensitivity, and maintaining independence. He covers:Why “eat less protein” headlines can miss important contextWhat mTOR and FGF21 have to do with protein restriction and longevityWhy rodent studies do not always translate cleanly to human healthHow sarcopenia and anabolic resistance change protein needs with ageWhy the protein RDA is a minimum, not a personalized target for health optimizationHow muscle supports glucose control and insulin sensitivityWhy protein needs depend on age, activity level, metabolic health, pregnancy, recovery, and training statusHow exercise, fasting, and lower insulin may influence similar cellular pathways without sacrificing adequate protein Protein needs are personal. A sedentary 35-year-old, a 70-year-old trying to preserve muscle, an athlete, and someone recovering from illness are not all aiming for the same target. Age, activity, metabolic health, and muscle goals should shape the conversation. 🎙️ We want to hear from you! Take our quick podcast survey at the link and enter for a chance to win. No purchase necessary. Open to U.S. residents and international participants 18+. Ends 9/15/26 at 11:59 PM PT. Void where prohibited: https://metmind.co/survey-listeners 👉 Want to stay up to date with the latest research on metabolic health and metabolic psychiatry? Sign up for our newsletter to stay informed: metabolicmind.org/about-us/newsletter/ 🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode. #MetabolicMind #KetogenicTherapy #ProteinNeeds Expert Featured: Bret Scher, MD - Baszucki Group Medical Director & Host of the Metabolic Mind Podcasthttps://www.linkedin.com/in/bret-scher-08baaa102/https://www.instagram.com/drscher858/?hl=enhttps://x.com/bschermd Resources Mentioned: The hallmarks of protein and amino acid restriction in aging and longevityhttps://www.cell.com/cell-press-blue/fulltext/S3051-3839(26)00077-0 Free CME Clinician Trainings: Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon. Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-yt Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
August 27, 20268min
Number 3: BITESIZE: New GLP-1 Study Raises Metabolic Health Questions
Do GLP-1 medications improve metabolic health as much as they support weight loss? A new observational study in the Annals of Internal Medicine raises an important question about semaglutide, insulin discontinuation, type 2 diabetes, and what meaningful metabolic improvement may require. In this episode of Metabolic Mind, Dr. Bret Scher breaks down a real-world study of more than 9,000 veterans with type 2 diabetes who were using insulin and then added either a GLP-1 receptor agonist, SGLT2 inhibitor, or DPP4 inhibitor. Despite semaglutide’s stronger association with weight loss, the study found similar insulin discontinuation rates across all three groups over three years. Dr. Scher covers:Why weight loss and metabolic health improvements may not always move togetherWhat insulin discontinuation can reveal about insulin resistance and beta cell functionWhy semaglutide did not outperform older diabetes medications in this studyThe limitations of observational research and real-world medication dataHow GLP-1 medications and therapeutic carbohydrate reduction may work through complementary mechanismsWhy combining GLP-1s with therapeutic carbohydrate reduction may be an important area for future research and clinical practice This conversation takes a closer look at what metabolic health means, and why the path from weight loss to insulin independence may be more complex than the scale alone can show. 👉 Want to stay up to date with the latest research on metabolic health and metabolic psychiatry? Sign up for our newsletter to stay informed: metabolicmind.org/about-us/newsletter/ 🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode. #MetabolicMind #KetogenicTherapy #GLP1 Expert Featured: Bret Scher, MD - Baszucki Group Medical Director & Host of the Metabolic Mind Podcasthttps://www.linkedin.com/in/bret-scher-08baaa102/https://www.instagram.com/drscher858/?hl=enhttps://x.com/bschermd Resources Mentioned: Comparative Effectiveness of Glucagon-like Peptide-1 Receptor Agonists Versus Oral Agents for Insulin Discontinuation in Type 2 Diabetes : A Target Trial Emulationhttps://www.acpjournals.org/doi/10.7326/ANNALS-25-05216 Free CME Clinician Trainings: Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon. Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-yt Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
August 13, 20266min
Number 4: BITESIZE: Cholesterol Results Explained: Beyond the LDL Number
A red flag next to your LDL number can feel alarming, but LDL is only one part of a much larger cardiovascular risk picture. In this episode of Metabolic Mind, cardiologist and lipidologist Dr. Bret Scher explains how to read a cholesterol panel with more context and less fear. Dr. Scher walks through LDL, triglycerides, HDL, non-HDL cholesterol, ApoB, Lp(a), and the triglyceride-to-HDL ratio. He also explains how the 2026 cholesterol guidelines use the PREVENT risk calculator, where LDL targets currently stand, and why individual risk factors, metabolic health, family history, and direct measures of vascular disease can change the conversation. He covers:Why LDL should not be read in isolationWhat triglycerides and HDL can reveal about metabolic healthWhy Dr. Scher pays attention to the triglyceride-to-HDL ratioWhen LDL above 190 may raise concern for familial hypercholesterolemiaWhy Lp(a) should be measured at least once in adulthoodHow ApoB differs from LDL cholesterolWhat the PREVENT risk calculator includesHow coronary calcium scans and CT angiograms act as tools that may help refine riskWhy LDL targets vary by risk categoryWhy metabolic health, insulin resistance, and individual preferences and priorities should be part of the discussion A cholesterol panel can start a thoughtful conversation with your healthcare provider. One number rarely tells the whole story, and better decisions come from looking at the full cardiometabolic picture. 🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode. 🎙️ Take the Metabolic Mind Podcast Listener Survey for a chance to win! We’d love your feedback on what you’re enjoying, what you’d like to hear more of, and how we can make the podcast even more helpful. Complete the quick survey by September 15 for a chance to win a Metabolic Mind giveaway bundle featuring a Keto-Mojo meter, books from Dr. Chris Palmer and Dr. Georgia Ede, Metabolic Mind swag, and more. Winners will be notified September 18. Take the survey here: https://metmind.co/survey-listeners No purchase necessary. Open to U.S. residents and international participants 18+. Ends 9/15/26 at 11:59 PM PT. Void where prohibited. #MetabolicMind #KetogenicTherapy #Cholesterol #HeartHealth Expert Featured: Bret Scher, MD - Baszucki Group Medical Director & Host of the Metabolic Mind Podcasthttps://www.linkedin.com/in/bret-scher-08baaa102/https://www.instagram.com/drscher858/?hl=enhttps://x.com/bschermd Free CME Clinician Trainings: Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon. Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-yt Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
September 10, 202614min
Number 5: Carnivore vs. Vegan Keto: Can Both Work?
Can carnivore and vegan diets both be used as ketogenic therapies? In this episode of Metabolic Mind, Dr. Bret Scher speaks with registered dietitian Denise Potter about two widely debated approaches to nutrition. They explore how each can be evaluated when someone is considering a ketogenic diet to support psychiatric, neurological, or metabolic health. Denise brings more than 30 years of clinical experience, including approximately 20 years working with medical ketogenic therapies. She explains the importance of risk-benefit analysis, how clinicians can assess potential nutrient gaps, and how lab testing, supplementation when indicated, and individualized support may help identify and manage potential risks. They cover:The difference between a carnivore diet and a carnivore ketogenic dietWhy some people report mental and physical health improvements with carnivore ketogenic approachesCommon questions about vitamin C, iodine, electrolytes, fiber, calcium, omega-3s, and LDLWhy bowel habits and the microbiome require clinical contextHow a vegan ketogenic diet can be formulated, including Denise’s recommendation to pay close attention to B12 supplementationProtein quality, bioavailability, and amino acid considerations in vegan ketogenic dietsThe role of tracking, lab work, and follow-up testingHow clinicians can evaluate restrictive dietary patterns through a medical risk-benefit lens This conversation offers a practical look at how different ketogenic approaches may be designed, monitored, and adjusted with individualized guidance and appropriate clinical support. 💡 Whether you’re considering a carnivore ketogenic approach or a more plant-based one, the quality of the diet itself can make a significant difference in outcomes. Learn more about what a well-formulated ketogenic diet looks like on our blog: metabolicmind.org/resources/library/blog/perspectives-in-metabolic-psychiatry/well-formulated-ketogenic-diet/ 🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode. 🎙️ Take the Metabolic Mind Podcast Listener Survey for a chance to win! We’d love your feedback on what you’re enjoying, what you’d like to hear more of, and how we can make the podcast even more helpful. Complete the quick survey by September 15 for a chance to win a Metabolic Mind giveaway bundle featuring a Keto-Mojo meter, books from Dr. Chris Palmer and Dr. Georgia Ede, Metabolic Mind swag, and more. Winners will be notified September 18. Take the survey here: https://metmind.co/survey-listeners No purchase necessary. Open to U.S. residents and international participants 18+. Ends 9/15/26 at 11:59 PM PT. Void where prohibited. #MetabolicMind #KetogenicTherapy #VeganKeto #Carnivore Expert Featured: Denise Potter RDN, CDCEShttps://advancedketogenictherapies.com/https://www.facebook.com/PotterDietitianConsulting/https://www.instagram.com/advancedketogenictherapies/https://www.linkedin.com/company/advanced-ketogenic-therapies/ Free CME Clinician Trainings: Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon. Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-yt Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
September 08, 20261h 1min