<a target="_blank" href="https://www.buzzsprout.com/twilio/text_messages/1535644/open_sms">Send us a text</a>About the guest: Gregory Scherrer, PharmD, PhD is a neuroscientist whose lab at the University of North Carolina studies the neural basis of pain, including its sensory, emotional, and cognitive components. Episode summary: Nick and Dr. Scherrer discuss: the neural basis of pain sensation & pain perception; opioids & the opioid system; cognitive modulation of painful experiences; neural basis of placebo effects; endogenous opioid system; and more.Related episodes:<ul><li><a href='https://mindandmatter.substack.com/publish/post/46728100'>M&M #52</a>: Pain Drugs, NSAIDs, Opioids, Oxycodone, Heroin, Fentanyl & the Neuroscience of Pain | David Roberson</li></ul>*This content is never meant to serve as medical advice. <a rel="payment" href="https://mindandmatter.substack.com/p/how-to-support-mind-and-matter">Support the show</a>Affiliates: <ul> <li> <a href='https://download.seedoilscout.com/xhLZ?af_xp=custom&pid=affiliate&c=Nick%20Jikomes'>Seed Oil Scout</a>: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.</li> <li> <a href='https://santabarbaranutrients.com/products/ketocitra'>KetoCitra</a>—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)</li> <li> <a href='https://www.lumen.me/shop?fid=8731&discount=MINDMATTER'>Lumen device</a> to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off</li> <li> <a href='https://siphoxhealth.com/?sca_ref=5338127.lZ39LNbYg8'>SiPhox Health</a>—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount.</li> </ul> For all the ways you can <a href='https://mindandmatter.substack.com/p/how-to-support-mind-and-matter'>support my efforts</a>

Send us a text About the guest: Gregory Scherrer, PharmD, PhD is a neuroscientist whose lab at the University of North Carolina studies the neural basis of pain, including its sensory, emotional, and cognitive components. Episode summary: Nick and Dr. Scherrer discuss: the neural basis of pain sensation & pain perception; opioids & the opioid system; cognitive modulation of painful experiences; neural basis of placebo effects; endogenous opioid system; and more. Related episodes:M&M #52: Pain Drugs, NSAIDs, Opioids, Oxycodone, Heroin, Fentanyl & the Neuroscience of Pain | David Roberson*This content is never meant to serve as medical advice. Support the show Affiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

<a href="https://www.buzzsprout.com/twilio/text_messages/1535644/open_sms" rel="noopener noreferrer">Send us a text</a>About the guest: Gregory Scherrer, PharmD, PhD is a neuroscientist whose lab at the University of North Carolina studies the neural basis of pain, including its sensory, emotional, and cognitive components.&nbsp;Episode summary: Nick and Dr. Scherrer discuss: the neural basis of pain sensation &amp; pain perception; opioids &amp; the opioid system; cognitive modulation of painful experiences; neural basis of placebo effects; endogenous opioid system; and more.Related episodes:<ul><li><a href="https://mindandmatter.substack.com/publish/post/46728100" rel="noopener noreferrer">M&amp;M #52</a>: Pain Drugs, NSAIDs, Opioids, Oxycodone, Heroin, Fentanyl &amp; the Neuroscience of Pain | David Roberson</li></ul>*This content is never meant to serve as medical advice. <a href="https://mindandmatter.substack.com/p/how-to-support-mind-and-matter" rel="noopener noreferrer">Support the show</a>Affiliates: <ul> <li> <a href="https://download.seedoilscout.com/xhLZ?af_xp=custom&amp;pid=affiliate&amp;c=Nick%20Jikomes" rel="noopener noreferrer">Seed Oil Scout</a>: Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app.</li> <li> <a href="https://santabarbaranutrients.com/products/ketocitra" rel="noopener noreferrer">KetoCitra</a>—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)</li> <li> <a href="https://www.lumen.me/shop?fid=8731&amp;discount=MINDMATTER" rel="noopener noreferrer">Lumen device</a> to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off</li> <li> <a href="https://siphoxhealth.com/?sca_ref=5338127.lZ39LNbYg8" rel="noopener noreferrer">SiPhox Health</a>—Affordable at-home blood testing. Key health markers, visualized &amp; explained. Code TRIKOMES for a 20% discount.</li> </ul> For all the ways you can <a href="https://mindandmatter.substack.com/p/how-to-support-mind-and-matter" rel="noopener noreferrer">support my efforts</a>

Neural Basis of Pain, Placebo Effects, Opioid Pain Relief & Addiction | Gregory Scherrer | 177

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists &amp; thinkers alive today about how your mind-body reacts to what you feed it. The weekly <a href="https://mindandmatter.substack.com/podcast?sort=top">M&amp;M podcast</a> features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today. Not medical advice. At M&amp;M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it. As the host, my aim is to help you better understand how the body &amp; mind work by curating &amp; synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet. I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint. My beliefs: <ul><li><a href="https://mindandmatter.substack.com/p/the-psychiatry-of-metabolism">Taking ownership of your health starts with taking ownership of your information diet</a>.</li><li>All knowledge is provisional and we must work hard to prevent ourselves from becoming attached to our favorite ideas &amp; preferred conclusions.</li><li>Wisdom comes from an iterative, trial-and-error process of learning and unlearning. Letting go of pre-conceived notions can be painful, but <a href="https://mindandmatter.substack.com/p/what-is-psychological-dissociation-78d">pain is information.</a></li></ul> Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload &amp; historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi: <ul><li>“Γνῶθι σεαυτόν” (Know thyself)</li><li>“Μηδὲν ἄγαν” (Nothing in excess)</li><li>“Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)</li></ul>

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Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it. The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today. Not medical advice. At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it. As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet. I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint. My beliefs: Taking ownership of your health starts with taking ownership of your information diet.All knowledge is provisional and we must work hard to prevent ourselves from becoming attached to our favorite ideas & preferred conclusions.Wisdom comes from an iterative, trial-and-error process of learning and unlearning. Letting go of pre-conceived notions can be painful, but pain is information. Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi: “Γνῶθι σεαυτόν” (Know thyself)“Μηδὲν ἄγαν” (Nothing in excess)“Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists &amp; thinkers alive today about how your mind-body reacts to what you feed it. The weekly <a href="https://mindandmatter.substack.com/podcast?sort=top" rel="noopener noreferrer">M&amp;M podcast</a> features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today. Not medical advice. At M&amp;M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it. As the host, my aim is to help you better understand how the body &amp; mind work by curating &amp; synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet. I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint. My beliefs: <ul><li><a href="https://mindandmatter.substack.com/p/the-psychiatry-of-metabolism" rel="noopener noreferrer">Taking ownership of your health starts with taking ownership of your information diet</a>.</li><li>All knowledge is provisional and we must work hard to prevent ourselves from becoming attached to our favorite ideas &amp; preferred conclusions.</li><li>Wisdom comes from an iterative, trial-and-error process of learning and unlearning. Letting go of pre-conceived notions can be painful, but <a href="https://mindandmatter.substack.com/p/what-is-psychological-dissociation-78d" rel="noopener noreferrer">pain is information.</a></li></ul> Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload &amp; historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi: <ul><li>“Γνῶθι σεαυτόν” (Know thyself)</li><li>“Μηδὲν ἄγαν” (Nothing in excess)</li><li>“Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)</li></ul>

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Neural Basis of Pain, Placebo Effects, Opioid Pain Relief & Addiction | Gregory Scherrer | 177

Neural Basis of Pain, Placebo Effects, Opioid Pain Relief & Addiction | Gregory Scherrer | 177

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