Brad Jacobs has made a fortune in his career buying and building big logistics companies, like United Rentals, Waste Management, XPO (trucking company), GXO (warehouses), and RXO (freight brokerage). His current venture is QXO, which raised billions of dollars in order to enter the building supply industry. After a long search and a couple months of battling with the executive team, QXO announced last week that it would be acquiring publicly traded roofing supply company Beacon Roofing for $11 billion. So why expand into roofing supply? And why Beacon specifically? We sat down with Brad to talk about the roofing industry, his vision for improving the company, what other opportunities are out there, and what he's seeing in the general economy right now.

Read more:
QXO Agrees to Acquire Beacon Roofing Supply in $11 Billion Deal
Affordable Housing Developers Stalled by Blocked Federal Funds

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President Trump wants higher tariffs, and he also wants more industrial production in the United States. This we know. In the meantime, a coterie of economists and pundits have tried to assemble a larger intellectual architecture to explain that strategy in a coherent way. The story they tell is one where America gets paid by its allies for national security and access to American markets, while the US brings down its debt and deficits, and weakens the dollar, so as to make US manufacturing more globally competitive. Whether Trump sees things this way himself, and whether it will actually work is an entirely separate question. On this episode of the podcast, we speak with Jim Millstein, co-chair of Guggenheim Securities, about what he sees as the massive risks underway with this line of thinking. During his time in government, he was closely involved with the conservatorship arrangement of the GSEs, so we also talk about the possibility of re-privatizing Fannie Mae and Freddie Mac.

Read more:
Dalio Warns of US Debt Crisis ‘Heart Attack’ Within Three Years
Wishful Thinking Won’t Solve the US Debt Crisis

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Last week, the US market sold off sharply. The S&P 500 fell as much as 3.6% on Monday alone, entering technical correction territory. Momentum trades were hit particularly hard and stocks that had been winners for years suddenly became losers, while ones that had been losers suddenly outperformed. Perhaps the strangest thing though, is that volatility didn't really surge as things sold off. The VIX — sometimes called Wall Street's "Fear Gauge" — went up, but it didn't even reach levels that we saw in 2024 or 2022. So what happened? And why was the selloff so short and kind of strange with the lack of vol? On this episode, we speak with Charlie McElligott, Nomura strategist, about what exactly has been happening.

Read only: 
Hedge-Fund Momentum Bets Crater All at Once in Volatile Markets
The S&P 500’s Meltdown Into a Correction Only Took 16 Days

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We finally did it. We finally did an episode on the Jones Act. For years on the podcast, we've been referencing this controversial law from 1920, which places restrictions on domestic port-to-port transport in the United States. But we had never actually done an episode on what it is, why it was created, and why people feel so fervently about either keeping or maintaining it. There are plenty of people who feel that this law is an inhibitor of US growth, because domestic water-based shipment of goods requires a US-flagged, US-crewed, and US-built vessel. And yet the law persists — for over a century now. At our live show in Washington DC, we spoked with the Cato Institute's Colin Grabow (who took the anti side) and the Transportation Institute's Sara Fuentes (who took the pro side). They explained their respective positions on questions of the economics and national security in a lively, heated (but polite) debate.

Read more:
Jones Act Descended From Centuries of Lazy Protectionism
East Coast Gas Would Only Drop a Dime If Jones Act Lifted, Says JPMorgan
Jones Act Ships Competitive for US Fuel Exports as Freight Soars

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When Donald Trump won in November, one of the things that Wall Street was excited about was an expected liberalization of merger rules. There was a popular view that under Chair Lina Khan, the Biden FTC was overly stringent about what deals it would let go through, and that the new administration would give the greenlight more often. But at least so far, reality hasn't proven to be so simple. There hasn't been a big merger wave yet. And, in fact, the FTC under new Chair Andrew Ferguson has decided to keep the merger guidelines that Khan put in place. So does this mean continuity? At a live episode of the podcast taped in Washington DC, we spoke with Ferguson about the Trump administration's vision for antitrust. He talked about his philosophy of keeping corporate power in check and the tests he's using to preserve a competitive environment. He also walked us through the long history of the FTC and the notion of consumer welfare, plus why he thinks a more expansive interpretation of the term (beyond just lower prices) is in keeping with the history of conservative legal thought.

Read More: New DOJ Antitrust Chief Builds Team From Prior Administrations
Trump’s FTC Moves Ahead With Broad Microsoft Antitrust Probe

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Prediction markets are everywhere nowadays. You can go online and bet on political outcomes, or the weather, or how long Taylor Swift will stay together with Travis Kelce. But prediction markets have a long history, and one of the earliest involved betting on who would be the next pope. In fact, Renaissance Romans gambled on everything from papal elections to whether a particular noblewoman would give birth to a boy or girl. So why was betting such a big thing in 1500s Italy? How did the papal prediction market actually work? And what can it tell us about prediction markets today? We speak to Ryan Isakow, the author of the No Dumb Ideas substack.

Read More: A Live Experiment in Prediction Markets
Prediction Markets Are a Thing Now

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Housing affordability remains one of the single greatest sources of economic stress. Even if inflation measures were to come down, the simple cost of shelter is a huge burden on a wide swathe of the population. Hardly anyone disagrees with the idea of increasing supply, but this is easier said than done. There isn't a lot of spare construction capacity and the political fights over liberalizing zoning are tedious and slow. On this episode, we speak with Kevin Erdmann, a senior affiliated scholar at the Mercatus Center at George Mason University, who proposes a simple idea. He argues that after the Great Financial Crisis, regulators over-tightened lending standards, and in so doing, took out the entire "starter home" segment of the new housing market. He says that if Fannie and Freddie were to liberalize their lending standards, homebuilders would be incentivized to build more homes that cater to people with lower incomes and lower FICO scores, essentially re-creating a whole slice of the new home market that's disappeared over the last 15 years.

Read More:
US Homebuilders Face a Supply Chain Snarl From Tariff Battles
US Mortgage Rates Decline to 6.88%, Lowest Level This Year

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Markets have been selling off, with shares of tech companies like Nvidia down almost 20% so far this year. But even before the recent selloff, DeepSeek rattled the AI market and sparked questions over how US platforms will compete and actually monetize their technology. Despite all these hurdles, some investors remain tech optimists. Cathie Wood, the founder, CEO and chief investment officer of ARK Investment Management, is one of the most prominent, with ARK's Innovation Fund heavily invested in companies like Tesla, Coinbase and Roku. In this conversation, recorded live on stage at Bloomberg Invest, we discuss Cathie's view of potential opportunities in the space, and why she's expecting the Trump administration to create a Reagan Era-esque "golden age" for investors.

Read More: 
Cathie Wood Sees Trump Era as ‘Golden Age’ for Wall Street
Cathie Wood May Have Lost $14 Billion. But She’s Interesting

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You’ve heard about Chinese EVs. You’ve heard about Chinese batteries and solar panels. And recently you learned that China is near the cutting edge of AI research. Here’s another category: biotech. In 2019, the Chinese share of molecules licensed to Big Pharma companies was 0%. In 2024, it’s now 31%. On this episode we speak with Tim Opler, a biotech industry investment banker at Stifel. He explains how this industry has taken off in such a short period of time. Among the factors he cites: a generation of Chinese research scientists working in the US who hit a ceiling in terms of promotion and thus went back home to start companies. It’s also far cheaper to run clinical trials in China, due to the structure of the healthcare system. We also talk about the broad history of the pharmaceutical industry, how it’s evolved, and what impact, if any, AI will have on drug discovery.

Read More:
Former J&J Scientist Bets on China Biotech
Chinese Health Stocks Surge on DeepSeek Integration Potential

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One of the first moves made by the Trump administration was to change the nature of grants made by the National Institutes of Health. Under the new policy, there's a 15% cap on "indirect costs" associated with a given grant. This is money that essentially pays for institutional overhead, not directly related to the new costs of the specific project itself. So how do NIH grants actually work? What are the direct and indirect costs? What is the effect that's already playing out? On this episode, we speak to Carole LaBonne, a biologist and researcher at Northwestern University, on what she's already seeing from the changes.

Read more:
Trump’s Science Agency Pick Says He Won’t Cut More Personnel
The US Is Withdrawing From Global Health at a Dangerous Time

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