In this episode, Josh and Michael begin their second two-part expedition, this time exploring HER2-positive breast cancer, an area of oncology that has been much like your favourite Instagram or TikTok celebrity: at the forefront of the hottest new trends. Neither Josh nor Mikey have a favourite Instagram or TikTok celebrity because they are old and out of touch, but the shifts in HER2-positive breast cancer may be their favourite oncological TikTok celebrity. For the reasons behind such a stretched analogy, listen on!

Links to studies discussed in this episode (subscription may be required):

NeoSphere: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(11)70336-9/fulltext

KATHERINE: https://www.nejm.org/doi/full/10.1056/nejmoa1814017

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Find us on Twitter @InquisitiveOnc!

If you want us to look at a specific trial or subject, email us at [email protected]

Art courtesy of Taryn Silver

Music courtesy of AlexiAction: https://pixabay.com/users/alexiaction-26977400/

Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.

Hosted on Acast. See acast.com/privacy for more information.

In this episode, Josh and Michael once again tackle immunotherapy in its application to metastatic urothelial cancer. Some say immunotherapy should be used up front. Others say that it should be used when all previous treatments have failed. And still, others are wondering about that Richard Nixon/Spock impression from last week and how it could be topped. For answers to all those questions and more, you'll have to listen on...

Links to papers discussed in this episode (subscription may be required):

JAVELIN-100: https://www.nejm.org/doi/full/10.1056/NEJMoa2002788

KEYNOTE 045: https://www.nejm.org/doi/full/10.1056/nejmoa1613683

For more episodes, resources and blog posts, visit www.inquisitiveonc.com

Find us on Twitter @InquisitiveOnc!

If you want us to look at a specific trial or subject, email us at [email protected]

Art courtesy of Taryn Silver

Music courtesy of AlexiAction: https://pixabay.com/users/alexiaction-26977400/

Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.

Hosted on Acast. See acast.com/privacy for more information.

In this extraordinary episode, Josh and Michael continue their journey to the earth's centre and the unknown with more European Society of Medical Oncology (ESMO) highlights. 

Since last week, Michael has realised that his French needs a bit of work, so they stuck to their guns and avoided google translate. Josh feels they should work on their Spanish to prepare for ESMO in Madrid in 2023. But before these dashing young Doctors get too excited for next year, more pivotal studies must be reported for your enjoyment! This episode focuses on colorectal, and Michael dabbles in some genitourinary and skin research.

Find us @InquisitiveOnc for fun oncology facts and links to the latest episodes!

All abstracts discussed in this episode are available from https://oncologypro.esmo.org. ESMO membership may be required.

Colorectal: FRESCO-2, NICHE-2, MOUNTAINEER, CAIRO5

Genitourinary: RADICALS-HD, COSMIC 313;

Skin: SWOG1801; Neoadjuvant Cemiplimab (NEJM)

For more episodes, resources and blog posts, visit inquisitiveonc.com

Find us on Twitter @InquisitiveOnc!

If you want us to look at a specific trial or subject, email us at [email protected]

Art courtesy of Taryn Silver

Music courtesy of AlexiAction: https://pixabay.com/users/alexiaction-26977400/

Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.

Hosted on Acast. See acast.com/privacy for more information.

In this very special episode, Josh and Michael hope to fulfil their fantasy of attending the European Society of Medical Oncology's (ESMO) yearly Congress, where they rub elbows with oncology's biggest movers and shakers; learn about the latest groundbreaking studies; and, in Michael's case, speak French with an accent lifted from a Monty Python sketch. The fact that they were stuck at home for the entire conference won't stand in the way of them from highlighting some of the best, most exciting studies presented in Paris.

Find us @InquisitiveOnc for fun oncology facts and links to the latest episodes!

All abstracts discussed in this episode are available from https://oncologypro.esmo.org. ESMO membership may be required.

Lung: ADAURA, CODEBREAK 200, INCREASE, IPSOS, Checkmate 816, APPLE

Breast: BELLINI, TROPiCS-02

Upper GI: LEAP-002, PRODIGE-65-UCGI-36-GEMPAX, RLY-4008

For more episodes, resources and blog posts, visit inquisitiveonc.com

Find us on Twitter @InquisitiveOnc!

If you want us to look at a specific trial or subject, email us at [email protected]

Art courtesy of Taryn Silver

Music courtesy of AlexiAction: https://pixabay.com/users/alexiaction-26977400/

Fanfare theme courtesy of StudioKolomna: https://pixabay.com/users/studiokolomna-2073170/

Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.

Hosted on Acast. See acast.com/privacy for more information.

"Hepatobiliary cancer, the final frontier." So begins our double-headed sojourn into two of the most challenging to-treat cancers many oncologists will encounter, but one that ends on a surprisingly positive note. Also, there's a cameo that absolutely no one will see coming...

Links to studies discussed in this episode (subscription may be required):

TOPAZ-1: https://evidence.nejm.org/doi/full/10.1056/EVIDoa220001

IMbrave150: https://www.nejm.org/doi/10.1056/NEJMoa1915745

Barcelona Liver Cancer Staging: https://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/attachment/fb5943f9-9201-4128-848a-626d744c651f/gr1_lrg.jpg

Source: Reig M, et al. "BCLC strategy for prognosis prediction and treatment recommendation: the 2022 Update." Journal of Hepatology. November 2021. Available from: https://doi.org/10.1016/j.jhep.2021.11.018

Art courtesy of Taryn Silver

Music courtesy of AlexiAction: https://pixabay.com/users/alexiaction-26977400/

Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.

Hosted on Acast. See acast.com/privacy for more information.

In episode 5, Michael and Josh dive into the complex world of hormone receptor-positive breast cancer. While early-stage breast cancer boasts fantastic cure rates many other cancers can only dream of, this evolving space must contend with multiple players, including aromatase inhibitors, tamoxifen and now abemaciclib (CDK 4/6 inhibitor). How best to approach adjuvant endocrine therapy is difficult, but Michael and Josh are on the case!

Links to papers discussed in this episode (subscription may be required):

SOFT/TEXT: Prudence et al. (2018): https://www.nejm.org/doi/full/10.1056/NEJMoa1803164

MonarchE: Johnston et al. (2020): https://pubmed.ncbi.nlm.nih.gov/32954927/

For more episodes, resources and blog posts, visit inquisitiveonc.com

Find us on Twitter @InquisitiveOnc!

If you want us to look at a specific trial or subject, email us at [email protected]

Art courtesy of Taryn Silver

Music courtesy of AlexiAction: https://pixabay.com/users/alexiaction-26977400/

Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.

Hosted on Acast. See acast.com/privacy for more information.

Four episodes already! How time flies when you're having fun. In this episode, Josh and Michael discuss metastatic lung cancer, an area of oncology where a survival benefit of a few months generates cheers, tears and standing ovations. So what happens when studies start to improve patients' outcomes by YEARS? I don't know, but there were almost certainly minds that were thoroughly blown. Join us for this most optimistic of episodes!

Links to papers discussed in this episode (subscription may be required):

KEYNOTE-189: https://www.nejm.org/doi/full/10.1056/nejmoa1801005

FLAURA: https://www.nejm.org/doi/full/10.1056/NEJMoa1913662

For more episodes, resources and blog posts, visit inquisitiveonc.com

Find us on Twitter @InquisitiveOnc!

If you want us to look at a specific trial or subject, email us at [email protected]

Art courtesy of Taryn Silver

Music courtesy of AlexiAction: https://pixabay.com/users/alexiaction-26977400/

Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.

Hosted on Acast. See acast.com/privacy for more information.

In this episode, Michael and Josh discuss the scourge that is metastatic mesothelioma. This genuinely awful disease continues to inflict significant mortality and morbidity on patients exposed to asbestos worldwide. One of our more grim episodes thus far, but never fear; we have still crammed in more dad jokes than one can wave a bag of chemotherapy at.

Links to papers discussed in this episode (subscription may be required):

Vogelzang et al (2003): https://ascopubs.org/doi/10.1200/jco.2003.11.136

CHECKMATE-743: https://www.thelancet.com/article/S0140-6736(20)32714-8/fulltext

For more episodes, resources and blog posts, visit inquisitiveonc.com

Find us on Twitter @InquisitiveOnc!

If you want us to look at a specific trial or subject, email us at [email protected]

Art courtesy of Taryn Silver

Music courtesy of AlexiAction: https://pixabay.com/users/alexiaction-26977400/

Editor's Note: the background noise is wind from a storm that hit Melbourne on the day of recording. It is not a cat being put through a blender

Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.

Hosted on Acast. See acast.com/privacy for more information.

In this episode, Josh and Michael discuss the incredible story of the treatment of metastatic melanoma, the immunotherapy revolution, and why this relegated a perfectly decent targeted therapy to second place on the podium. Join us for a titanic battle on a par with Macbeth vs Macduff, Rocky Balboa vs Apollo Creed, or Regina George vs that bus...

Links to papers discussed (subscription may be required):

CHECKMATE-067: https://www.nejm.org/doi/full/10.1056/nejmoa1910836

COMBI-D: https://www.nejm.org/doi/full/10.1056/NEJMoa1904059

For more episodes, resources and blog posts, visit inquisitiveonc.com

Find us on Twitter @InquisitiveOnc!

If you want us to look at a specific trial or subject, email us at [email protected]

Cover art courtesy of Taryn Silver

Music courtesy of AlexiAction: https://pixabay.com/users/alexiaction-26977400/

Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.

Hosted on Acast. See acast.com/privacy for more information.

In their inaugural episode, Michael and Josh discuss one of the most common cancers a budding oncologist will encounter: prostate cancer. But is there more to this cancer than meets the eye? Will they make sense of the whole confusing mess? Is this whole podcasting thing way too much for them to handle? Listen on to find out!

Links to papers discussed (subscription may be required):

CHAARTED: https://www.nejm.org/doi/full/10.1056/nejmoa1503747

ENZAMET: https://www.nejm.org/doi/full/10.1056/nejmoa1903835

For more episodes, resources and blog posts, visit inquisitiveonc.com

Find us on Twitter @InquisitiveOnc!

If you want us to look at a specific trial or subject, email us at [email protected]

Cover art courtesy of Taryn Silver

Music courtesy of AlexiAction: https://pixabay.com/users/alexiaction-26977400/

Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.

Hosted on Acast. See acast.com/privacy for more information.