This Week in Startups

Orchestrating Smarter AI Systems with AI21 Labs’ Yoav Shoham | AI Basics with Google Cloud


Listen Later

In this episode of AI Basics, Jason sits down with Yoav Shoham — Stanford professor emeritus and co-founder of AI21 Labs, creators of Jurassic-2, Wordtune, and the new orchestration system Maestro.

They unpack:

  • Why enterprise AI struggles with reliability
  • What orchestration really means (and why LLMs alone aren't enough)
  • The pitfalls of “agent-washing”
  • Small vs large models, agent-to-agent protocols, and where real opportunities lie

This one is for founders building with AI — if you're navigating hallucinations, chasing automation, or exploring multi-agent workflows, this episode is a must.

*

Timestamps:

(0:00) Yoav Shoham joins Jason to discuss AI Basics.

(1:05) What AI21 Labs is building — from Jurassic-2 to Maestro

(5:49) The overuse and confusion of the seductive term “agent”

(8:22) Small models vs large models: what's best for enterprise?

(10:53) The verticalization of AI: legal, accounting, and beyond

(12:17) The challenge of agent-to-agent communication and shared semantics

(17:08) What’s overhyped vs underhyped in AI — Yoav’s advice for founders

*

Uncover more valuable insights from AI leaders in Google Cloud's 'Future of AI: Perspectives for Startups' report.

https://goo.gle/futureofai

*

Explore Further

Google Cloud’s Report: The Future of AI

Get insights from 23 leading experts on how startups can leverage AI for real business impact.

👉 Read the full report

More AI Basics Episodes

Founders, operators, and builders — catch up on our full Startup Basics series (Legal, Finance, Growth & AI):

👉 thisweekinstartups.com/basics

Links from episde:

  • Google Cloud — Build smarter with AI tools built for startups
  • AI21 Labs — Makers of Wordtune, Jurassic-2, and Maestro
  • Maestro — Orchestrate AI agents and tools across workflows
  • Jamba — AI21’s hybrid language model with breakthrough efficiency


Learn About Google’s A2A (Agent-to-Agent) Protocol

The next evolution in agent interoperability and coordination:

  • Official A2A Announcement
  • Hands-on A2A Tutorial (Medium)
  • *
  • Follow Yoav:

    X: https://x.com/yshoham

    LinkedIn: https://www.linkedin.com/in/yoavshoham/

    *

    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis

    *

    Follow TWiST:

    Twitter: https://twitter.com/TWiStartups

    YouTube: https://www.youtube.com/thisweekin

    Instagram: https://www.instagram.com/thisweekinstartups

    TikTok: https://www.tiktok.com/@thisweekinstartups

    Substack: https://twistartups.substack.com

    ...more
    View all episodesView all episodes
    Download on the App Store

    This Week in StartupsBy Jason Calacanis

    • 4.2
    • 4.2
    • 4.2
    • 4.2
    • 4.2

    4.2

    1,274 ratings


    More shows like This Week in Startups

    View all
    The Twenty Minute VC (20VC): Venture Capital | Startup Funding | The Pitch by Harry Stebbings

    The Twenty Minute VC (20VC): Venture Capital | Startup Funding | The Pitch

    536 Listeners

    The a16z Show by Andreessen Horowitz

    The a16z Show

    1,105 Listeners

    Invest Like the Best with Patrick O'Shaughnessy by Colossus | Investing & Business Podcasts

    Invest Like the Best with Patrick O'Shaughnessy

    2,342 Listeners

    Founders by David Senra

    Founders

    2,221 Listeners

    Masters of Scale by WaitWhat

    Masters of Scale

    3,992 Listeners

    Y Combinator Startup Podcast by Y Combinator

    Y Combinator Startup Podcast

    233 Listeners

    All-In with Chamath, Jason, Sacks & Friedberg by All-In Podcast, LLC

    All-In with Chamath, Jason, Sacks & Friedberg

    10,254 Listeners

    Dwarkesh Podcast by Dwarkesh Patel

    Dwarkesh Podcast

    551 Listeners

    Joe Lonsdale: American Optimist by Joe Lonsdale

    Joe Lonsdale: American Optimist

    171 Listeners

    ACQ2 by Acquired by Ben Gilbert and David Rosenthal

    ACQ2 by Acquired

    300 Listeners

    No Priors: Artificial Intelligence | Technology | Startups by Conviction

    No Priors: Artificial Intelligence | Technology | Startups

    150 Listeners

    BG2Pod with Brad Gerstner and Bill Gurley by BG2Pod

    BG2Pod with Brad Gerstner and Bill Gurley

    475 Listeners

    AI + a16z by a16z

    AI + a16z

    34 Listeners

    TBPN by John Coogan & Jordi Hays

    TBPN

    140 Listeners

    Uncapped with Jack Altman by Alt Capital

    Uncapped with Jack Altman

    42 Listeners