Lyme disease is a world-wide pandemic. It is a life taking disease often undiagnosed or missed diagnosed as other diseases and conditions as it is the Great Mimicker. Medical ozone therapy has been used successfully and safely to treat to treat it. We will discuss how it works and the different methods that can be used. Also, the gut microbiome plays an important role in Lyme disease mostly do the overuse of antibiotics. We will discuss this important and vital issue to attaining health during and after treatment fir Lyme.