Hosted by Bloomberg Opinion senior executive editor Tim O'Brien, Crash Course will bring listeners directly into the arenas where epic business and social upheavals occur. Every week, Crash Course will explore the lessons to be learned when creativity and ambition collide with competition and power -- on Wall Street and Main Street, and in Hollywood and Washington.

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The battle against humanity’s most challenging diseases is happening at the intersection of business and medicine. A new six-episode podcast called Targeting the Toughest Diseases explores how Vertex Pharmaceuticals, a Boston-based biotech company, is using innovative tools, methods, and a unique philosophy to search for treatments and cures. Produced by Bloomberg Media Studios and Vertex, the podcast’s latest episode features NBA great Alonzo Mourning recounting his fight against kidney disease, and how future generations of patients may have an easier time of it. You can subscribe today on Apple Podcasts, Spotify or wherever you listen to your favorite podcasts.

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If you’re like many people, there’s a good chance that your weight and calorie considerations play a big role in food decisions. Intuitive eating, an Internet-famous movement all about healing people’s relationships with food, says it shouldn’t be that way. The final episode of “Losing It” explores what it means to eat intuitively, and asks the question: Does it work? 

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What if the dangers of being heavy have been overstated, or misrepresented? This new episode of the podcast series “Losing It” explores the relationship between health and weight, and the argument that we focus on the scale too much and not enough on healthy behaviors.

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Companies like WW, formerly Weight Watchers, and Noom, which makes a popular weight-loss app, have a new pitch for would-be members: that they can lose weight with a holistic lifestyle approach instead of dieting. This new episode of podcast series “Losing It” explores why the backlash against dieting is happening, how companies are getting in on the action, and whether we're actually over dieting and losing weight. 

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We all think we know the basics of weight loss. It is all about consuming fewer calories than you burn. Eat less, move more. Calories in, calories out. But there’s much more to it than these simple equations, as a trip to the enormous Pennington Biomedical Research Center in Baton Rouge, Louisiana - a hub of such research - shows. In this episode, we break down the science of why it’s so hard to lose weight, and look at what the kinds of stories heralded as a weight-loss success really look like in practice. 

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The South Beach Diet became an incredible success in the early 2000s, blowing past booksellers’ expectations, dominating the cultural moment and becoming a huge business. In the third episode of Losing It, we fly down to glamorous Miami to tell the story of the South Beach Diet and break down the formula for a hit diet. 

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When it comes to dieting, what’s old is new again. In the second episode of Losing we take a trip back in time through diet history — and explore why we keep falling for these absurd-sounding regimens decade after decade.  

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Calorie counts are everywhere from food packages to weight-loss apps. But calories aren’t all that they appear to be. In the series premiere of Losing it, we dive into how we got the calorie so wrong – and pretty much everything else about weight.

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For much of human history, we’ve turned to diets to lose weight and improve our health. But it’s mostly been in vain. Because no matter how much the number on the scale drops, chances are the weight will come back. That’s just what the science says. 

But when it comes to our weight, the facts don’t seem to make much difference. Dieting still has a grip on all of us. 

Losing It, a new series from Bloomberg’s Prognosis, investigates how we got weight loss so wrong — and whether there’s a better way forward. Losing It launches on July 12. Subscribe to Prognosis today on Apple Podcasts, Spotify or wherever you get your favorite podcasts.

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