In this two-part podcast, Dr. Brian S. Barnett, Cleveland Clinic, and Dr. Erin E. Mauney, Massachusetts General Hospital for Children, joins moderator Dr. Adam Brown, Cleveland Clinic, to discuss the Cleveland Clinic Journal of Medicine article, “Psychedelic assisted therapy: An overview for the internist.” The trio focuses on what an internist needs to know, from the potential effects, risks, and therapeutic applications of these powerful drugs, with a focus on MDMA-assisted therapy for posttraumatic stress disorder (PTSD) and psilocybin-assisted therapy for depression.