Psychedelics Today

PT409 – Erica Rex & Mona Sobhani, Ph.D. – Pathology, The DSM, and The Ontological Shock of Psychedelic Experiences


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In this episode, Joe interviews Erica Rex: award-winning journalist, past guest and writer, and participant in one of the first ever clinical trials using psilocybin to treat cancer-related depression; and Mona Sobhani, Ph.D.: cognitive neuroscientist and the author of "Proof of Spiritual Phenomena: A Neuroscientist’s Discovery of the Ineffable Mysteries of the Universe."

As Rex discovered the power of psychedelics through a clinical trial, she discusses a huge problem she discovered: that researchers are not preparing participants enough for the ontological shock they may go through in trying to match unexplainable happenings to a rigid framework (or match the normal to a framework that has suddenly shifted) – that while patients have support at the clinic, it all disappears when they return to normal life. She believes that all too often, researchers are doing only what is necessary to be able to continue to receive funding, push drugs through the FDA, and prescribe a pill. 

And as psychedelics changed Sobhani from very constrained scientific thinking to being very open to new ideas about consciousness and spirituality, she learned that many scientists had similar stories, and that coming out of the psychedelic closet is sometimes the best thing to do to normalize these ways of healing. 

They discuss the challenges of newcomers trying to explain their experience without having the necessary language; how we still don't truly understand mental illness; how the DSM just clusters symptoms to fit 'disorders' into a box; how society has started pathologizing anything we find unpleasant (which of course, is a part of being human); Gary Fisher’s research on using LSD and psilocybin for schizophrenic children, why science needs to combine consciousness research and psychedelics research, and more.

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