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Neurogastroenterologist Dr. Zachary Spiritos explains the likely connection between leaky gut and rising rates of inflammatory conditions like endometriosis. He discusses how intestinal permeability may be influenced by stress and dietary factors, potentially contributing to various chronic conditions.

• Leaky gut (increased intestinal permeability) may be bidirectionally linked with endometriosis and other inflammatory conditions
• Reliable testing for leaky gut doesn't exist yet, but research suggests connections with autoimmune conditions
• Modern lifestyle factors including processed foods and stress may contribute to intestinal permeability issues
• GLP-1 agonists like semaglutide can benefit many GI conditions but may worsen gastroparesis or constipation
• Personalized risk assessment is crucial when considering weight management medications with pre-existing GI issues

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