Comprehensive medication management (CMM) provided by a clinical pharmacist can improve the quality of care and reduce health care costs through the optimization of medication use and a significant reduction in medication-related problems. Dr. Curtis Haas discusses the limitations of the current evidence and recommends structure, process, and outcome measures to ensure that the key elements of CMM that drive the observed benefits are implemented with fidelity to address the goals of the quadruple aim. Read the full text article at: https://accpjournals.onlinelibrary.wiley.com/doi/10.1002/jac5.1767.