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On this episode of the Real Life Pharmacology podcast, I discuss the ins and outs of lamotrigine pharmacology.
Lamotrigine has a very slow dose titration schedule due to the risk of drug induced rash.
Sedation, GI upset, and CNS changes are the most common adverse effects associated with lamotrigine.
Lamotrigine concentrations can be increased by valproic acid, so we tend to use lower starting doses.
Phenytoin and carbamazepine can lower concentrations of lamotrigine.
I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!
On this episode of the Real Life Pharmacology podcast, I breakdown propofol pharmacology.
Propofol is a CNS depressant that is used for general anesthesia.
I discuss propofol infusion syndrome in this episode and what to look out for clinically.
Adding a benzodiazepine or opioid to propofol may have a synergistic effect and the propofol dose may need to be reduced.
I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!
On this episode of the RLP podcast, I discuss glucagon pharmacology.
It is important to remember with glucagon that patients will still require glucose following administration to improve their blood sugar numbers.
Glucagon is typically reserved for moderate to severe episodes of hypoglycemia when patients have altered consciousness.
The major adverse effect with glucagon is nausea and vomiting which often may prevent oral intake of glucose for some time after administration.
I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!
Dulaglutide is a GLP-1 agonist used in the management of diabetes.
Dulaglutide has 4 different dosages that can be used to help lower A1C. As the dose goes up, so does the potential for adverse effects however.
Like most of the GLP-1 agonists, dulaglutide is only available as an injection. Semaglutide is an exception to this.
Nausea is the primary adverse effect of dulaglutide which some patients may get used to over time.
I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.
Dapagliflozin is an SGLT-2 Inhibitor that reduces blood sugar by increasing the excretion of sugar through the urine.
Genital and urinary infections is a potential risk with the use of SGLT2 Inhibitors like dapagliflozin.
Dapagliflozin has received FDA approval for use in heart failure (in patients even without diabetes).
Be aware of agents that may enhance the risk for hypoglycemia such an insulin and sulfonylureas.
I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!
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