Real Life Pharmacology - Pharmacology Education for Health Care Professionals

By Eric Christianson, PharmD; Pharmacology Expert and Clinical PharmacistMedicine Health & Fitness Education

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Real Life Pharmacology - Pharmacology Education for Health Care Professionals episodes

August 27, 2020 Tizanidine Pharmacology
Tizanidine is primarily broken down by CYP1A2. Ciprofloxacin can inhibit CYP1A2 and cause higher tizanidine concentrations.

Tizanidine has a similar classification as clonidine. Pay attention to adverse effects like hypotension and bradycardia.

When patients taking routine tizanidine stop taking it, there is potential for a discontinuation syndrome that may lead to rebound hypertension.

Dry mouth and CNS depression are common adverse effects of tizanidine.
12 min
August 20, 2020 Valacyclovir Pharmacology
Valacyclovir can be used for various viral infections such as herpes virus and varicella.
The primary clinical advantage of valacyclovir compared to acyclovir is that it is dosed less frequently.
Valacyclovir may have some mild CYP1A2 inhibitory effect. I discuss the clinical relevance of this on this episode.
GI upset can occur so I usually recommend to give it with food even though it may be given with or without food.
I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

14 min
August 20, 2020 Valacyclovir Pharmacology
Valacyclovir can be used for various viral infections such as herpes virus and varicella.

The primary clinical advantage of valacyclovir compared to acyclovir is that it is dosed less frequently.

Valacyclovir may have some mild CYP1A2 inhibitory effect. I discuss the clinical relevance of this on this episode.

GI upset can occur so I usually recommend to give it with food even though it may be given with or without food.
14 min
August 13, 2020 Abacavir Pharmacology
Abacavir is a nucleoside reverse transcriptase inhibitor used in the management of HIV.
In patients who have the HLA-B*5701 allele, they are at much greater risk for hypersensitivity reactions.
Lactic acidosis and hepatomegaly are potential complications with the use of abacavir.
While abacavir is not known for a large number of drug interactions, I discuss a few that you have a chance to run into.
I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

13 min
August 13, 2020 Abacavir Pharmacology
Abacavir is a nucleoside reverse transcriptase inhibitor used in the management of HIV.

In patients who have the HLA-B*5701 allele, they are at much greater risk for hypersensitivity reactions.

Lactic acidosis and hepatomegaly are potential complications with the use of abacavir.

While abacavir is not known for a large number of drug interactions, I discuss a few that you have a chance to run into.
13 min
August 06, 2020 Sertraline Pharmacology
Sertraline is an SSRI. It has the highest potential to cause diarrhea of any SSRI.
Sertraline is often called “Squirtraline” because of its potential to cause diarrhea.
Sertraline has a much shorter half-life than fluoxetine. I discuss why that may be important in this podcast episode.
I discuss the role of serotonin in platelet aggregation and how sertraline may affect this.
I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

17 min
August 06, 2020 Sertraline Pharmacology
Sertraline is an SSRI. It has the highest potential to cause diarrhea of any SSRI.

Sertraline is often called "Squirtraline" because of its potential to cause diarrhea.

Sertraline has a much shorter half-life than fluoxetine. I discuss why that may be important in this podcast episode.

I discuss the role of serotonin in platelet aggregation and how sertraline may affect this.
17 min
July 30, 2020 Fosfomycin Pharmacology
Fosfomycin is an antibacterial agents that can be utilized in the management of uncomplicated UTIs.
Uniquely, fosfomycin comes as a packet that needs to be mixed with COOL water. I discuss this further on the podcast.
Typhoid and Cholera vaccine effectiveness may be reduced when used with fosfomycin.
When there is kidney or systemic infection involvement, it is recommended to avoid the use of fosfomycin.
I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

14 min
July 30, 2020 Fosfomycin Pharmacology
Fosfomycin is an antibacterial agents that can be utilized in the management of uncomplicated UTIs.

Uniquely, fosfomycin comes as a packet that needs to be mixed with COOL water. I discuss this further on the podcast.

Typhoid and Cholera vaccine effectiveness may be reduced when used with fosfomycin.

When there is kidney or systemic infection involvement, it is recommended to avoid the use of fosfomycin.
14 min
July 23, 2020 Simvastatin Pharmacology
Simvastatin use has declined over time due to more potent statins being available and due to numerous drug interactions.
Grapefruit juice can inhibit CYP3A4 which will increase the concentrations of simvastatin.
Genetic variations in SLCO1B1 can lead to patients being more susceptible to simvastatin toxicity.
Simvastatin is a lipophilic statin. I discuss why this is important and how it might impact clinical decisions.
I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

16 min