Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

By Eric Christianson, PharmD; Pharmacology Expert and Clinical PharmacistMedicineHealth & FitnessEducation
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Real Life Pharmacology - Pharmacology Education for Health Care Professionals episodes

  • Simvastatin Pharmacology
    Simvastatin use has declined over time due to more potent statins being available and due to numerous drug interactions.



    Grapefruit juice can inhibit CYP3A4 which will increase the concentrations of simvastatin.



    Genetic variations in SLCO1B1 can lead to patients being more susceptible to simvastatin toxicity.



    Simvastatin is a lipophilic statin. I discuss why this is important and how it might impact clinical decisions.
    16 min
  • Citalopram Pharmacology

    Citalopram is an SSRI used in the management of depression, anxiety, OCD, and PTSD.

    How do you manage the risk of citalopram causing QTc prolongation? I discuss it further in the podcast.

    Omeprazole can inhibit CYP2C19 which affects the metabolism of citalopram. I discuss the clinical impacts of this interaction in the podcast.

    Geriatric dosing with citalopram is recommended to be lower than traditional adult dosing. I discuss this further in the podcast.

    Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

    I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.



    18 min
  • Citalopram Pharmacology
    Citalopram is an SSRI used in the management of depression, anxiety, OCD, and PTSD.



    How do you manage the risk of citalopram causing QTc prolongation? I discuss it further in the podcast.



    Omeprazole can inhibit CYP2C19 which affects the metabolism of citalopram. I discuss the clinical impacts of this interaction in the podcast.



    Geriatric dosing with citalopram is recommended to be lower than traditional adult dosing. I discuss this further in the podcast.
    18 min
  • Epoetin Alfa Pharmacology

    Epoetin alfa is essential exogenous erythropoetin which can stimulate the production of red blood cells.

    It is critical to ensure adequate iron stores when using EPO.

    Risks for blood clots, strokes and heart attacks are critical to recognize with the use of epoetin.

    Dosage adjustments with epoetin are typically made with respect to the amount of change in hemoglobin. I discuss this further in the podcast.

    I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

    Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!



    15 min
  • Epoetin Alfa Pharmacology
    Epoetin alfa is essential exogenous erythropoetin which can stimulate the production of red blood cells.



    It is critical to ensure adequate iron stores when using EPO.



    Risks for blood clots, strokes and heart attacks are critical to recognize with the use of epoetin.



    Dosage adjustments with epoetin are typically made with respect to the amount of change in hemoglobin. I discuss this further in the podcast.
    15 min
  • Dexamethasone Pharmacology

    Dexamethasone has numerous possible indications such as asthma, chemotherapy-induced nausea and vomiting, and pain associated with inflammation.

    Dexamethasone is more potent than prednisone. Approximately 0.75 mg of dexamethasone is equivalent to 5 mg of prednisone.

    When using dexamethasone, recall that it can raise blood sugars. Monitor this closely in patients with diabetes.

    A dexamethasone suppression test helps detect excessive endogenous production of cortisol.

    I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

    Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!



    13 min
  • Dexamethasone Pharmacology
    Dexamethasone has numerous possible indications such as asthma, chemotherapy-induced nausea and vomiting, and pain associated with inflammation.



    Dexamethasone is more potent than prednisone. Approximately 0.75 mg of dexamethasone is equivalent to 5 mg of prednisone.



    When using dexamethasone, recall that it can raise blood sugars. Monitor this closely in patients with diabetes.



    A dexamethasone suppression test helps detect excessive endogenous production of cortisol.
    13 min
  • Sildenafil Pharmacology

    On this episode, I discuss sildenafil pharmacology, adverse effects, and important drug interactions.

    Sildenafil’s most common and concerning adverse effect is in relation to its ability to lower blood pressure. I discuss this further in the podcast.

    Sildenafil can cause rare visual changes that patients should be aware of and report immediately to their pharmacist or physician.

    The sildenafil nitrate interaction is essential to know. I discuss it in this podcast episode.

    I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

    Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!



    14 min
  • Sildenafil Pharmacology
    On this episode, I discuss sildenafil pharmacology, adverse effects, and important drug interactions.



    Sildenafil's most common and concerning adverse effect is in relation to its ability to lower blood pressure. I discuss this further in the podcast.



    Sildenafil can cause rare visual changes that patients should be aware of and report immediately to their pharmacist or physician.



    The sildenafil nitrate interaction is essential to know. I discuss it in this podcast episode.
    14 min
  • Codeine Pharmacology

    On this episode, I discuss codeine pharmacology and practical clinical practice pearls.

    Codeine is metabolized by CYP2D6 to the active metabolite morphine. I discuss how this can be affected by genetics as well as other medications.

    Constipation is a problem with codeine and all opioids in general. Education and making a plan with patients to combat this side effect is important.

    Codeine is less potent than other opioids such as fentanyl, hydromorphone, and hydrocodone.

    I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

    Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!



    16 min

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