How have we made discoveries about the world around us and how has our understanding changed when we got it wrong? Adam Rutherford hosts Radio 4's discussion programme which starts the week, asking about the the nature of scientific discovery, understanding and changing our mind.

Andrea Wulf's latest book is The Traveller: The Revolutionary Life of George Forster and his Search for Humanity. She has reassessed the botanist and ethnologist who accompanied Captain Cook's second voyage, taking him from Antarctica to the tropical islands of the South Pacific. During this time, Forster studied diverse people, culture and nature and returned a confirmed opponent of empire, racism and slavery: he was celebrated in his lifetime, but has since been largely forgotten by history.

The geneticist Kathryn Paige Harden argues that the latest research complicates our ideas about blame, punishment and moral responsibility. In her new book Original Sin: The Genetics of Wrongdoing, the Problem of Blame and the Future of Forgiveness, she looks at the area where human behaviour meets inherited biology. She thinks we must look again at questions of wrong doing and free will, reassessing old ideas of guilt and accountability.

We are all hormonal all of the time, because to be hormonal is to be human says Saira Hameed, a leading endocrinologist. Hormones are the often misunderstood signalling system that makes our bodies function which she explain in her new book, Signals: The Inside Story of Our Hormones, separating medical breakthroughs from the obsessions of wellness influencers.

Producer: Ruth Watts