We live in a moment when the power to change the world often arrives before the wisdom to understand that power. CRISPR, a bacterial immunity process turned DNA editing tool, promises breakthroughs across scientific disciplines. But it also collapses long-standing boundaries between nature and human design.

In this episode, Jennifer Doudna – Nobel Prize-winning chemist and founder of the Innovative Genomics Institute – reflects on the thrilling discovery of CRISPR as a gene-editing tool and what it means to suddenly possess the ability to edit the code of life itself. From the ongoing explosion of new opportunities to the shock of seeing ethical boundaries crossed in real time, is there a safe path forward in shaping the future of biological life as we know it?

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Mentioned in this Episode:

The Double Helix — James D. Watson (Book, 1968) https://www.simonandschuster.com/books/The-Double-Helix/James-D-Watson/9780743216302

The Pleasure of Finding Things Out — Richard P. Feynman (Book, 1999) https://www.hachettebookgroup.com/titles/richard-p-feynman/the-pleasure-of-finding-things-out/9780465023951/

“The RNA World” — Walter Gilbert (Article, 1986) https://www.nature.com/articles/319618a0.pdf

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity — Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A. Doudna, Emmanuelle Charpentier (Paper, 2012). https://www.science.org/doi/10.1126/science.1225829

“Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos” — Niu et al. (Paper, 2014) https://www.cell.com/fulltext/S0092-8674(14)00171-6

Infant with rare, incurable disease is first to successfully receive personalized gene therapy treatment – (Article, May 2025) https://www.nih.gov/news-events/news-releases/infant-rare-incurable-disease-first-successfully-receive-personalized-gene-therapy-treatment

Human Genome Editing: Science, Ethics, and Governance — National Academies (Report, 2017) https://nap.nationalacademies.org/catalog/24623/human-genome-editing-science-ethics-and-governance

“Can CRISPR Cut Methane Emissions From Cow Guts?” — UC Davis (Article, 2023) https://www.ucdavis.edu/food/news/can-crispr-cut-methane-emissions-cow-guts
Where to find Jennifer Doudna: 

Website, Innovative Genomics Institute: https://innovativegenomics.org/people/jennifer-doudna/

Instagram, Innovative Genomics Institute: https://www.instagram.com/innovativegenomics/

Bluesky, Innovative Genomics Institute: https://bsky.app/profile/innovativegenomics.bsky.social

Linkedin, Innovative Genomics Institute: https://www.linkedin.com/company/innovative-genomics-institute

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Credits 

Executive Producers: Nicolas Berggruen, Nathan Gardels, Nils Gilman, Dawn Nakagawa, & Jason Hoch

Producers: Grant Slater, Alex Gardels, & Nathalia Ramos

Associate Producer: Elissa Mardiney

Theme Music: Marcus Bagala

Audio Engineer: Aaron Bastinelli & Kyle Scott Wilson

Futurology is a production of Studio B and Wavland for the Berggruen Institute in Los Angeles, California.