Solvable

Welcome to Risky Business, a show about making better decisions.

Today, Maria has lessons from a poker tournament she recently played in Monte Carlo, where she made it to the final table. Then, Nate discusses what RFK Jr.’s impressive polling numbers could mean for Biden and Trump. And Nate and Maria discuss Caitlin Clark and what her story tells us – or doesn’t – about the gender pay gap. 

Further Reading:

The Biggest Bluff by Maria Konnikova

On The Edge by Nate Silver (forthcoming)

"RFK Jr. Says Doctors Found a Dead Worm in His Brain" (NYT)

"What the conversation about Caitlin Clark’s pay gets wrong" (CNN)

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The Leap from Maria Konnikova

Silver Bulletin from Nate Silver

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The Happiness Lab’s Dr. Laurie Santos brings together other Pushkin hosts to mark the International Day of Happiness. Revisionist History’s Malcolm Gladwell talks about the benefits of the misery of running in a Canadian winter. Dr. Maya Shankar from A Slight Change of Plans talks about quieting her mental chatter. And Cautionary Tales host Tim Harford surprises everyone with the happiness lessons to be learned from a colonoscopy.

Hear more of The Happiness Lab HERE.

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Melissa Gallardo’s childhood smelled like dark-roast coffee and lavender Fabulosa. As an adult, she found it difficult to find fragrances that made her feel at home, so she took it into her own hands and taught herself to make candles. It was a fun hobby side hustle until a 5,400 candle order almost sent her over the edge. 

Join Ben and Tanya as they chat with Melissa, founder of Bonita Fierce Candles, about taking her passion project from her side hustle to her full-time job. Discover how she started the company in her spare room while working 9-5 and finishing a graduate degree, built a relatable brand by focusing on her personal experience and how she landed her first big order. These are the Unshakeables.

The Unshakeables is brought to you by Chase for Business and Ruby Studio by iHeartMedia 

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The digital revolution has been happening for a while now, but with 5G, it’s about to reach a whole new level. IT departments are about to rule the world. So in this paid partnership with T-Mobile for Business, Malcolm sits with leaders in the world of retail and healthcare to discuss how their industries are changing.

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Back in the 1960s, a committee of seven Seattle residents met regularly to decide which patients with chronic kidney disease were “worthy” of life-saving dialysis.  Whoever wasn’t selected by the committee would likely die within months. An exposé of this so-called “God Squad” helped spark the formation of a new field: bioethics. In this prequel to playing god?, we’ll find out how this committee made life-and-death decisions, and why something like it is unlikely to happen again. 

Show Notes:

This episode features interviews with: 

Richard M. Mizelle, Jr., Associate Professor of History, University of Houston

Kate Butler, Assistant Professor of Nephrology, University of Washington School of Medicine

The God Squad was just one of many notable cases that led to the formation of the field of bioethics. The Hastings Center, a bioethics research institute, has compiled a timeline of many of the most famous cases and their impact. Check it out here. 

The Berman Institute has also collected oral histories– first hand accounts of the doctors, philosophers, lawyers and other scholars who were involved in many of these cases. You can explore that collection here. 

To learn more about the ethics issues raised in this episode, visit the Berman Institute’s episode guide. 

The Greenwall Foundation seeks to make bioethics integral to decisions in health care, policy, and research. Learn more at greenwall.org.

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In this episode we head into the future to learn about a controversial technology that could change the face of reproduction. Researchers are developing a technology called in vitro gametogenesis (IVG), which can reprogram human cells–like a skin cell–to become eggs or sperm. With IVG we could reach a future where anyone could produce either eggs or sperm, in potentially limitless quantities. This could open up a whole world of new options for how humans reproduce. Startup companies are working to bring this science to the public in ways that bypass the usual research routes for new reproductive technologies. When would it be ethically acceptable to try IVG to make a baby? How can we ensure the technology will be used ethically, including how it should be regulated? 

Show Notes:

This episode features interviews with:

Amander Clark, Professor, Molecular, Cell and Developmental Biology,  University of California, Los Angeles

I. Glenn Cohen, James A. Attwood and Leslie Williams Professor of Law, Deputy Dean and Faculty Director, Petrie-Flom Center for Health Law Policy, Biotechnology & Bioethics, Harvard Law School

In 2023, the National Academies held a meeting to discuss the scientific, ethical, and legal implications of IVG. You can watch this meeting and learn more about IVG here. 

To learn more about the ethics issues raised in this episode, visit the Berman Institute’s episode guide. 

The Greenwall Foundation seeks to make bioethics integral to decisions in health care, policy, and research. Learn more at greenwall.org.

See omnystudio.com/listener for privacy information.

Cheryl Yoder’s son Jase, was born with an incurable rare disease called spinal muscular atrophy (SMA), which meant he was unlikely to live beyond two years old. Jase managed to get a spot in a clinical trial for an experimental drug. It halted the disease and allowed him to grow up as an active little boy–a miracle cure.  

A growing list of uniquely tailored drugs can treat, and even cure, some debilitating and fatal diseases. But often these so-called “miracle drugs” can cost a fortune. In this episode: why miracle drugs cost so much, why it’s so hard to do anything about the costs and how challenging it is to work towards equitable access for patients who can benefit from them.

Show Notes:

In addition to Cheryl Yoder, this episode features interviews with:

Tom Crawford, Co-Director, Muscular Dystrophy Association Clinic and Professor of Neurology, Johns Hopkins University School of Medicine

Holly Fernandez Lynch, Assistant Professor of Medical Ethics and Health Policy, University of Pennsylvania

You can learn more about spinal muscular atrophy, learn about the latest research, and find resources for those affected by the disease here. 

To learn more about the ethics issues raised in this episode, visit the Berman Institute’s episode guide. 

The Greenwall Foundation seeks to make bioethics integral to decisions in health care, policy, and research. Learn more at greenwall.org.

See omnystudio.com/listener for privacy information.

For years Brandy Ellis had tried everything to treat depression but nothing worked. Then one day she heard about something called deep brain stimulation, a brain implant that treats some neurological conditions. This technological intervention–that changed her life–also raises ethics questions. Because brain implants have the potential to change our personalities and our performance– where do we draw the line? Are we giving such devices too much control over who we are by using them to alter fundamental human traits like our emotions?

Note: This episode contains references to suicide.  If you or someone you know is struggling with thoughts of suicide, there are resources that can help you. In the US, dial 988 to reach the Suicide & Crisis lifeline for free 24/7 confidential support from a trained listener. Or text SAVE to 741741 to reach a trained helper at the Crisis Text Line.

Show Notes:

In addition to Brandy Ellis, this episode features interviews with: 

Patricio Riva Posse, Associate Professor, Psychiatry and Behavioral Sciences, Emory University School of Medicine

Karen Rommelfanger, Founding Director, Institute of Neuroethics; CEO, Ningen Neuroethics Co-Lab;  Senior Faculty Fellow, Emory University Center for Ethics (previously director of the Neuroethics Program); Adjunct Associate Professor,  Departments of Neurology, Psychiatry & Behavioral Sciences, Emory University School of Medicine.

You can learn more about deep brain stimulation (DBS) here.

To learn more about the ethics issues raised in this episode, visit the Berman Institute’s episode guide.  

The Greenwall Foundation seeks to make bioethics integral to decisions in health care, policy, and research. Learn more at greenwall.org.

See omnystudio.com/listener for privacy information.

When Laurie Strongin’s son Henry was born with the rare, often fatal disease of Fanconi anemia, doctors told her that the best way to save his life was with an umbilical cord blood transplant from a genetically matched sibling. But Henry had no matching siblings. Laurie and her husband then got a call from a doctor with a novel idea of combining three technologies to create a child who was guaranteed to be a genetic match, raising the question: is it ethical to create a life in order to save another?

Show Notes:

In addition to Laurie Strongin, this episode features interviews with:

John Wagner, Co-Leader of the Transplantation and Cellular Therapy Program, Professor in the Division of Transplant and Cell Therapy in the Department of Pediatrics, and the McKnight-Presidential Endowed Chair, Department of Pediatrics, Division of Pediatric Blood and Marrow Transplantation & Cellular Therapy, University of Minnesota

Jeffrey Kahn, Andreas C. Dracopolous Director of the Johns Hopkins Berman Institute of Bioethics

You can learn more about Fanconi anemia, learn about the latest research, and find resources for those affected by the disease here. You can read more about the Strongin-Goldbergs’ and the Nashes’ stories in this New York Times article from 2001. 

Laurie Strongin went on to found the Hope for Henry Foundation, which works with hospitals to help provide support and better care for pediatric patients.

To learn more about the ethics issues raised in this episode, visit the Berman Institute’s episode guide.  

The Greenwall Foundation seeks to make bioethics integral to decisions in health care, policy, and research. Learn more at greenwall.org.

See omnystudio.com/listener for privacy information.

Jen Dingle yearned to get pregnant and have children, but there was one problem: she was born without a uterus. So when she was ready to have children she was desperate to find a way to do it. That’s when she learned that a local research hospital was starting up a uterus transplant program – one of the first in the U.S. Jen shares her personal experience and we explore the risks, financial costs and ethical issues of this new combination of organ transplant and reproductive technology.  

Show Notes:

In addition to Jen Dingle, this episode features interviews with: 

Ruth Farrell, Vice Chair of Research of the OB/GYN and Women’s Health Institute, and Professor at the Center for Bioethics at the Cleveland Clinic

Liza Johanneson, Medical Director of Uterus Transplant, Baylor Scott & White Medical Center

You can learn more about the uterus transplant program at Baylor here. Dr. Farrell co-authored this article reviewing the state of uterus transplantation as of 2021. 

To learn more about the ethics issues raised in this episode, visit the Berman Institute’s episode guide. 

The Greenwall Foundation seeks to make bioethics integral to decisions in health care, policy, and research. Learn more at greenwall.org.

Disclaimer: The views and opinions of those interviewed for this episode are their own and do not necessarily reflect the views or positions of any entities they represent.

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