In this episode of The SHEA Podcast, Dr. Katie Chiotos (Children’s Hospital of Philadelphia) and Dr. Trevor Van Schooneveld (University of Nebraska Medical Center) discuss the stewardship of metagenomic sequencing (mNGS) in infectious disease care. They explore how to make results clinically actionable, avoid overuse or misinterpretation, and integrate mNGS into stewardship and infection prevention programs. The conversation also looks ahead to the future of mNGS and the role stewardship leaders will play in guiding its responsible use.