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João, Joanne e Rapha discutem 3 clinicagens na insulinoterapia:  

1. Quando indicar? 

2. Como começar e titular a dose? 

3. Não alcancei o alvo, como ajustar? 

Referências:

1. DRAZNIN, Boris et al. 9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes-2022. Diabetes care, v. 45, n. Supplement_1, p. S125-S143, 2022.

2. Uptodate Fev/2022. General principles of insulin therapy in diabetes mellitus.Ruth S Weinstock, David M Nathan, Jean E Mulder.

3. Uptodate 2022. Insulin therapy in type 2 diabetes mellitus. Deborah J Wexler, David M Nathan, Jean E Mulder.

4. COWART, Kevin. Overbasalization: addressing hesitancy in treatment intensification beyond basal insulin. Clinical Diabetes, v. 38, n. 3, p. 304-310, 2020.

5. NATHAN, David M. et al. Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes care, v. 29, n. 8, p. 1963-1972, 2006.

6. TAYLOR, Roy et al. Appropriate insulin regimes for type 2 diabetes: a multicenter randomized crossover study. Diabetes Care, v. 23, n. 11, p. 1612-1618, 2000.

7. UK PROSPECTIVE DIABETES STUDY (UKPDS) GROUP et al. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). The lancet, v. 352, n. 9131, p. 837-853, 1998.

8. MADENIDOU, Anastasia-Vasiliki et al. Comparative benefits and harms of basal insulin analogues for type 2 diabetes: a systematic review and network meta-analysis. Annals of internal medicine, v. 169, n. 3, p. 165-174, 2018.