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Pedro Magno, Iago Jorge e Gabriel Cunha discutem os principais conceitos sobre manifestações clínicas e diagnóstico de mieloma múltiplo.

Quer saber mais sobre amiloidose, veja o tópico: https://www.tadeclinicagem.com.br/guia/321/amiloidose-manifestacoes-clinicas-e-diagnostico/

Minutagem:

00:10 Apresentação 

03:55 Definição

05:40 Epidemiologia

07:45 Como o paciente chega 

08:00 Mnemônicos 

09:00 Cálcio

11:50 Rim - disfunção renal

17:05 Anemia

19:50 Bone - osso

21:45 Outros sintomas além do CRAB

26: 45 Apresentação do paciente

27:00 Caso 1

27:45 Caso 2

28:30 Investigação

35:55 Retornando aos casos

38:30 Diagnóstico 

43:10 Retornando aos casos

44:00 Doenças e manifestações atípicas do mieloma

52:00 Encerramento

Referências:
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2. Kumar, Shaji K et al. “Multiple myeloma.” Nature reviews. Disease primers vol. 3 17046. 20 Jul. 2017, doi:10.1038/nrdp.2017.46
3. Rajkumar, S Vincent et al. “International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma.” The Lancet. Oncology vol. 15,12 (2014): e538-48. doi:10.1016/S1470-2045(14)70442-5
4. Dimopoulos, Meletios A et al. “Management of multiple myeloma-related renal impairment: recommendations from the International Myeloma Working Group.” The Lancet. Oncology vol. 24,7 (2023): e293-e311. doi:10.1016/S1470-2045(23)00223-1
5. Palumbo, Antonio, and Kenneth Anderson. “Multiple myeloma.” The New England journal of medicine vol. 364,11 (2011): 1046-60. doi:10.1056/NEJMra1011442
6. Nandra, Taran K et al. “Multiple myeloma: what a non-haematologist should know.” Clinical medicine (London, England) vol. 22,3 (2022): 230-233. doi:10.7861/clinmed.2022-0144
7. Sive, Jonathan et al. “Guidelines on the diagnosis, investigation and initial treatment of myeloma: a British Society for Haematology/UK Myeloma Forum Guideline.” British journal of haematology vol. 193,2 (2021): 245-268. doi:10.1111/bjh.17410
8. Mikhael, Joseph et al. “Treatment of Multiple Myeloma: ASCO and CCO Joint Clinical Practice Guideline.” Journal of clinical oncology : official journal of the American Society of Clinical Oncologyvol. 37,14 (2019): 1228-1263. doi:10.1200/JCO.18.02096
9. Marron, Thomas U et al. “Validation and Utility of the Free Light Chain Assay in Pleural Effusions of Patients With Multiple Myeloma.” Clinical lymphoma, myeloma & leukemia vol. 16,7 (2016): e113-7. doi:10.1016/j.clml.2016.04.008
10. Witzig, T E et al. “Quantitation of circulating peripheral blood plasma cells and their relationship to disease activity in patients with multiple myeloma.” Cancer vol. 72,1 (1993): 108-13. doi:10.1002/1097-0142(19930701)72:1<108::aid-cncr2820720121>3.0.co;2-t
11. Dimopoulos, M A et al. “Pathogenesis and treatment of renal failure in multiple myeloma.” Leukemia vol. 22,8 (2008): 1485-93. doi:10.1038/leu.2008.131
12. Agbuduwe, Charles et al. “Clinical presentation and outcomes of solitary plasmacytoma in a tertiary hospital in the UK.” Clinical medicine (London, England) vol. 20,5 (2020): e191-e195. doi:10.7861/clinmed.2019-0488
13. Leung, Nelson et al. “Monoclonal Gammopathy of Renal Significance.” The New England journal of medicine vol. 384,20 (2021): 1931-1941. doi:10.1056/NEJMra1810907