Sam Harris speaks with Siddhartha Mukherjee about the human desire to understand and manipulate heredity, the genius of Gregor Mendel, the ethics of altering our genes, the future of genetic medicine, patent issues in genetic research, and other topics.

Siddhartha Mukherjee is a cancer physician and researcher. He is an assistant professor of medicine at Columbia University and a staff cancer physician at the CU/NYU Presbyterian Hospital. A former Rhodes scholar, he graduated from Stanford University, University of Oxford (where he received a PhD studying cancer-causing viruses) and from Harvard Medical School. His laboratory focuses on discovering new cancer drugs using innovative biological methods. He has published articles and commentary in such journals as Nature, New England Journal of Medicine, Neuron and the Journal of Clinical Investigation and in publications such as the New York Times, The New Yorker, and the New Republic. His work was nominated for Best American Science Writing, 2000. He won the Pulitzer Prize for his book The Emperor of All Maladies: A Biography of Cancer. His most recent book is The Gene: An Intimate History.

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Episodes that have been re-released as part of the Best of Making Sense series may have been edited for relevance since their original airing.

Sam Harris speaks with Michael Pollan about his book How to Change Your Mind. They cover the resurgence of interest in psychedelics in clinical practice and end-of-life care, the “betterment of well people,” the relationship between thinking and mental suffering, the differences between psychedelics and meditation, the non-duality of consciousness, the brain’s “default mode network,” their experiences with various psychedelics, and other topics.

Michael Pollan is the author of eight books, including Cooked, Food Rules, In Defense of Food, The Omnivore’s Dilemma, and The Botany of Desire, all of which were New York Times bestsellers. A longtime contributor to the New York Times Magazine, he also teaches writing at Harvard and the University of California, Berkeley. In 2010, TIME magazine named him one of the one hundred most influential people in the world. His most recent book is This Is Your Mind on Plants.

Twitter: @michaelpollan

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Sam Harris speaks with Bari Weiss about her book How to Fight anti-Semitism. They discuss the three different strands of anti-Semitism (rightwing, leftwing, and Islamic), the Tree of Life shooting in Pittsburgh, the difference between anti-Semitism and other forms of racism, the history of anti-Semitism in the U.S., criticisms of Israel, and other topics.

Bari Weiss is the editor of Common Sense and the host of the podcast Honestly. From 2017 until 2020, Bari was a staff writer and editor for the Opinion section of The New York Times. Before joining the Times, Bari was an op-ed editor at the Wall Street Journal and an associate book review editor there. For two years, she was a senior editor at Tablet, the online magazine of Jewish news, politics, and culture, where she edited the site's political and news coverage. She regularly appears on shows like The View, Morning Joe and Real Time with Bill Maher.

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Sam Harris speaks with Peter Singer about the concept of universal moral truths, the ethics of violence, free speech, euthanasia, animal welfare, and other topics.

Peter Singer is the Professor of Bioethics in the University Center for Human Values at Princeton University.  He is the author of Animal Liberation, The Most Good You Can Do, Ethics in the Real World, and most recently Why Vegan? He is also the co-founder of The Life You Can Save, a nonprofit devoted to spreading his ideas about why we should be doing much more to improve the lives of people living in extreme poverty.

Website: www.petersinger.info

Twitter: @PeterSinger

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Sam Harris speaks with Eliezer Yudkowsky about the nature of intelligence, different types of AI, the “alignment problem,” IS vs OUGHT, the possibility that future AI might deceive us, the AI arms race, conscious AI, coordination problems, and other topics.

Eliezer Yudkowsky is a decision theorist and computer scientist at the Machine Intelligence Research Institute in Berkeley, California who is known for his work in technological forecasting. His publications include the Cambridge Handbook of Artificial Intelligence chapter “The Ethics of Artificial Intelligence,” co-authored with Nick Bostrom. Yudkowsky’s writings have helped spark a number of ongoing academic and public debates about the long-term impact of AI, and he has written a number of popular introductions to topics in cognitive science and formal epistemology, such as Rationality: From AI to Zombies and “Harry Potter and the Methods of Rationality.” He is also the author of Inadequate Equilibria: Where and How Civilizations Get Stuck.

Twitter: @ESYudkowsky

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Sam Harris speaks with James Clear about habit formation. They discuss the difference between creating good habits and discontinuing bad ones, the role of the environment, the misalignment between immediate and long term outcomes, the remembering self vs the experiencing self, goals vs systems, the compounding of incremental gains, the role of attention, the four laws of behavior change, “temptation bundling,” and other topics.

James Clear is an author and speaker focused on habits, decision-making, and continuous improvement. His work has appeared in The New York Times, Entrepreneur, Time, and on CBS This Morning. He is a regular speaker at Fortune 500 companies and his work is used by teams in the NFL, NBA, and MLB. His book Atomic Habits is a New York Times bestseller and has sold more than 9 million copies worldwide.

Website: www.jamesclear.com

Twitter: @jamesclear 

Instagram: @jamesclear

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Sam Harris speaks with Robert Plomin about the role that DNA plays in determining who we are. They discuss the birth of behavioral genetics, the taboo around studying the influence of genes on human psychology, controversies surrounding the topic of group differences, the first law of behavior genetics, heritability, nature and nurture, the mystery of unshared environment, the way genes help determine a person’s environment, epigenetics, the genetics of complex traits, dimensions vs disorders, the prospect of a GATTACA-like dystopia and genetic castes, heritability and equality of opportunity, the implications of genetics for parenting and education, DNA as a fortune-telling device, and other topics.

Robert Plomin is MRC Research Professor in Behavioral Genetics at the Institute of Psychiatry, Psychology and Neuroscience, King’s College London and has previously taught at the University of Colorado Boulder and at Pennsylvania State University. He has received lifetime research achievement awards from the major associations related to his field (Behavior Genetics Association, Association of Psychological Science, Society for Research in Child Development, International Society for Intelligence Research), as well as being made Fellow of the American Academy of Arts and Sciences, British Academy, American Academy of Political and Social Science, and Academy of Medical Sciences (UK).

Robert’s latest book, Blueprint: How DNA Makes Us Who We Are, makes the case that DNA inherited from our parents at the moment of conception can predict our psychological strengths and weaknesses.

Website: https://www.kcl.ac.uk/people/robert-plomin

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Sam Harris speaks with Scott Barry Kaufman about human well-being. They discuss intelligence and creativity, wisdom and transcendence, the history of humanistic psychology, Maslow’s hierarchy of needs, the connection between well-being and ethics, self-esteem, psychedelics and meditation, peak and plateau experiences, mortality salience, the pre-trans fallacy, intrinsic vs. extrinsic rewards, pathological altruism, intimacy vs. belonging, two aspects of self-transcendence, and other topics.

Scott Barry Kaufman is a humanistic psychologist exploring the depths of human potential. He has taught courses at the nation’s leading universities including Columbia University, University of Pennsylvania, and New York University. He wrote the column Beautiful Minds for Scientific American and hosts The Psychology Podcast, which discusses insights into the mind, brain, behavior, and creativity. He has also written for The Atlantic and Harvard Business Review.

Scott’s latest book Transcend: The New Science of Self-Actualization is a reimagining of Maslow’s famous hierarchy of needs. It provides new insights for realizing one’s full potential and living a creative, fulfilled, and connected life. His previous books include Ungifted: Intelligence Redefined, Wired to Create: Unraveling the Mysteries of the Creative Mind, and Twice Exceptional: Supporting and Educating Bright and Creative Students with Learning Difficulties. Scott is also credited for editing The Cambridge Handbook of Intelligence.

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Sam Harris speaks with Daniel Markovits about the problems with meritocracy. They discuss the nature of inequality in the United States, the disappearance of the leisure class, the difference between labor and capital as sources of inequality, the way the education system amplifies inequality, the shrinking middle class, deaths of despair, differing social norms among the elite and the working class, universal basic income, the relationship between meritocracy and political polarization, the illusion of earned advantages, and other topics.

Daniel Markovits is Guido Calabresi Professor of Law at Yale Law School and Founding Director of the Center for the Study of Private Law. Markovits works in the philosophical foundations of private law, moral and political philosophy, and behavioral economics. 

His writing has appeared in a number of notable publications including The New York Times, The Atlantic, Science, The American Economic Review, and The Yale Law Journal. His latest book, The Meritocracy Trap: How America’s Foundational Myth Feeds Inequality, Dismantles The Middle Class, and Devours The Elite, places meritocracy at the center of rising economic inequality and social and political dysfunction. The book takes up the law, economics, and politics of human capital to identify the mechanisms through which meritocracy breeds inequality and to expose the burdens that meritocratic inequality imposes on all who fall within meritocracy’s orbit. 

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Sam Harris speaks with David Benatar about his philosophy of “anti-natalism.” They discuss the asymmetry between the good and bad things in life, the ethics of existential risk, the moral landscape, the limits and paradoxes of introspection, the “experience machine” thought experiment, population ethics, and other topics.

David Benatar is Professor of Philosophy at University of Cape Town, South Africa. He is the author of Better Never to Have Been: The Harm of Coming Into Existence and The Human Predicament: A Candid Guide to Life’s Biggest Questions.

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