There's a new crop of psych meds that work through serotonin receptors, but not in the way you'd expect. They range from antipsychotics like lumateperone (Caplyta) to novel therapies for depression and anxiety like psilocybin and MDMA, as well as a few familiar meds like mirtazapine, trazodone, and quetiapine. Learn how the 5HT-2A receptor strings together their effects in some paradoxical ways.

Published on: 4/27/20

Duration: 28 minutes, 49 seconds

Article Referenced: "Nuplazid: Novel Mechanism, Modest Benefits (https://www.thecarlatreport.com/the-carlat-psychiatry-report/nuplazid-novel-mechanism-modest-benefits/)," The Carlat Psychiatry Report, April 2020

Feedback? Take the podcast survey. (http://www.thecalatreport.com/podcastsurvey)

There's a new crop of psych meds that work through serotonin receptors, but not in the way you'd expect. They range from antipsychotics like lumateperone (Caplyta) to novel therapies for depression and anxiety like psilocybin and MDMA, as well as a few familiar meds like mirtazapine, trazodone, and quetiapine. Learn how the 5HT-2A receptor strings together their effects in some paradoxical ways.

Published on: 4/27/20

Duration: 28 minutes, 49 seconds

Article Referenced: "Nuplazid: Novel Mechanism, Modest Benefits (https://www.thecarlatreport.com/the-carlat-psychiatry-report/nuplazid-novel-mechanism-modest-benefits/)," The Carlat Psychiatry Report, April 2020

Feedback? Take the podcast survey. (http://www.thecalatreport.com/podcastsurvey)

There's a new crop of psych meds that work through serotonin receptors, but not in the way you'd expect. They range from antipsychotics like lumateperone (Caplyta) to novel therapies for depression and anxiety like psilocybin and MDMA, as well as a few familiar meds like mirtazapine, trazodone, and quetiapine. Learn how the 5HT-2A receptor strings together their effects in some paradoxical ways.

Published on: 4/27/20

Duration: 28 minutes, 49 seconds

Article Referenced: "Nuplazid: Novel Mechanism, Modest Benefits (https://www.thecarlatreport.com/the-carlat-psychiatry-report/nuplazid-novel-mechanism-modest-benefits/)," The Carlat Psychiatry Report, April 2020

Feedback? Take the podcast survey. (http://www.thecalatreport.com/podcastsurvey)

Lithium takes on the coronavirus. Benzos impair facial recognition. Antipsychotic doses find their maximum, the profile of a lithium responder, and topiramate for compulsive shopping.

Published On: 4/21/20

Duration: 13 minutes, 51 seconds

Studies Referenced:

Garcez H, Fernandes C, Barbosa F, et al. Effects of benzodiazepines administration on identification of facial expressions of emotion: a meta-analysis. Psychopharmacology. 2020;237(1):1-9.

Nader D, Gowing L. Is Long-Term Benzodiazepine Use a Risk Factor for Cognitive Decline?Results of a Systematic Review. J Addictdoi:10.1155/2020/1569456

Nicoli de Mattos C, Kim HS, Marasaldi RF, et al. A 12-Week Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Topiramate for the Treatment of Compulsive Buying Disorder. Journal of Clinical Psychopharmacology.

Rybakowski JK. Antiviral and immunomodulatory effect of lithium. Pharmacopsychiatry. (https://www.ncbi.nlm.nih.gov/pubmed/11071016)

Lagadinou M, Onisor MO, Rigas A, et al. Antimicrobial properties on non-antibiotic drugs in the era of increased bacterial resistance. Antibiotics (Basel). 2020;9(3):E107. Published 2020 Mar 2. (https://www.ncbi.nlm.nih.gov/pubmed/32131427)

Scott J, Bellivier F, Manchia M, et al. Can network analysis shed light on predictors of lithium response in bipolar I disorder. Acta Psychiatr Scand. 10.1111/acps.13163 (https://onlinelibrary.wiley.com/doi/abs/10.1111/acps.13163)

Got feedback? Take the podcast survey. (https://www.thecarlatreport.com/podcastsurvey/)

Lithium takes on the coronavirus. Benzos impair facial recognition. Antipsychotic doses find their maximum, the profile of a lithium responder, and topiramate for compulsive shopping.

Published On: 4/21/20

Duration: 13 minutes, 51 seconds

Studies Referenced:

Garcez H, Fernandes C, Barbosa F, et al. Effects of benzodiazepines administration on identification of facial expressions of emotion: a meta-analysis. Psychopharmacology. 2020;237(1):1-9.

Nader D, Gowing L. Is Long-Term Benzodiazepine Use a Risk Factor for Cognitive Decline?Results of a Systematic Review. J Addictdoi:10.1155/2020/1569456

Nicoli de Mattos C, Kim HS, Marasaldi RF, et al. A 12-Week Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Topiramate for the Treatment of Compulsive Buying Disorder. Journal of Clinical Psychopharmacology.

Rybakowski JK. Antiviral and immunomodulatory effect of lithium. Pharmacopsychiatry. (https://www.ncbi.nlm.nih.gov/pubmed/11071016)

Lagadinou M, Onisor MO, Rigas A, et al. Antimicrobial properties on non-antibiotic drugs in the era of increased bacterial resistance. Antibiotics (Basel). 2020;9(3):E107. Published 2020 Mar 2. (https://www.ncbi.nlm.nih.gov/pubmed/32131427)

Scott J, Bellivier F, Manchia M, et al. Can network analysis shed light on predictors of lithium response in bipolar I disorder. Acta Psychiatr Scand. 10.1111/acps.13163 (https://onlinelibrary.wiley.com/doi/abs/10.1111/acps.13163)

Got feedback? Take the podcast survey. (https://www.thecarlatreport.com/podcastsurvey/)

Lithium takes on the coronavirus. Benzos impair facial recognition. Antipsychotic doses find their maximum, the profile of a lithium responder, and topiramate for compulsive shopping.

Published On: 4/21/20

Duration: 13 minutes, 51 seconds

Studies Referenced:

Garcez H, Fernandes C, Barbosa F, et al. Effects of benzodiazepines administration on identification of facial expressions of emotion: a meta-analysis. Psychopharmacology. 2020;237(1):1-9.

Nader D, Gowing L. Is Long-Term Benzodiazepine Use a Risk Factor for Cognitive Decline?Results of a Systematic Review. J Addictdoi:10.1155/2020/1569456

Nicoli de Mattos C, Kim HS, Marasaldi RF, et al. A 12-Week Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Topiramate for the Treatment of Compulsive Buying Disorder. Journal of Clinical Psychopharmacology.

Rybakowski JK. Antiviral and immunomodulatory effect of lithium. Pharmacopsychiatry. (https://www.ncbi.nlm.nih.gov/pubmed/11071016)

Lagadinou M, Onisor MO, Rigas A, et al. Antimicrobial properties on non-antibiotic drugs in the era of increased bacterial resistance. Antibiotics (Basel). 2020;9(3):E107. Published 2020 Mar 2. (https://www.ncbi.nlm.nih.gov/pubmed/32131427)

Scott J, Bellivier F, Manchia M, et al. Can network analysis shed light on predictors of lithium response in bipolar I disorder. Acta Psychiatr Scand. 10.1111/acps.13163 (https://onlinelibrary.wiley.com/doi/abs/10.1111/acps.13163)

Got feedback? Take the podcast survey. (https://www.thecarlatreport.com/podcastsurvey/)

Lithium takes on the coronavirus. Benzos impair facial recognition. Antipsychotic doses find their maximum, the profile of a lithium responder, and topiramate for compulsive shopping.

Published On: 4/21/20

Duration: 13 minutes, 51 seconds

Studies Referenced:

Garcez H, Fernandes C, Barbosa F, et al. Effects of benzodiazepines administration on identification of facial expressions of emotion: a meta-analysis. Psychopharmacology. 2020;237(1):1-9.

Nader D, Gowing L. Is Long-Term Benzodiazepine Use a Risk Factor for Cognitive Decline?Results of a Systematic Review. J Addictdoi:10.1155/2020/1569456

Nicoli de Mattos C, Kim HS, Marasaldi RF, et al. A 12-Week Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Topiramate for the Treatment of Compulsive Buying Disorder. Journal of Clinical Psychopharmacology.

Rybakowski JK. Antiviral and immunomodulatory effect of lithium. Pharmacopsychiatry. (https://www.ncbi.nlm.nih.gov/pubmed/11071016)

Lagadinou M, Onisor MO, Rigas A, et al. Antimicrobial properties on non-antibiotic drugs in the era of increased bacterial resistance. Antibiotics (Basel). 2020;9(3):E107. Published 2020 Mar 2. (https://www.ncbi.nlm.nih.gov/pubmed/32131427)

Scott J, Bellivier F, Manchia M, et al. Can network analysis shed light on predictors of lithium response in bipolar I disorder. Acta Psychiatr Scand. 10.1111/acps.13163 (https://onlinelibrary.wiley.com/doi/abs/10.1111/acps.13163)

Got feedback? Take the podcast survey. (https://www.thecarlatreport.com/podcastsurvey/)

We speak with David Osser, whose psychopharmacology algorithm project challenges many conventions about psychiatric medications. When antidepressants cause more depression. Psychotic disorders that don't respond to antipsychotics. When to trust the evidence, and what to do with clinical experience.

Published on: 4/13/20

Duration: 18 minutes, 56 seconds

Related Articles: "The Psychopharmacology Algorithm Project (https://www.thecarlatreport.com/the-carlat-psychiatry-report/the-psychopharmacology-algorithm-project/)," The Carlat Psychiatry Report, April 2020

Got feedback? Take the podcast survey. (https://www.thecarlatreport.com/podcastsurvey/)

We speak with David Osser, whose psychopharmacology algorithm project challenges many conventions about psychiatric medications. When antidepressants cause more depression. Psychotic disorders that don't respond to antipsychotics. When to trust the evidence, and what to do with clinical experience.

Published on: 4/13/20

Duration: 18 minutes, 56 seconds

Related Articles: "The Psychopharmacology Algorithm Project (https://www.thecarlatreport.com/the-carlat-psychiatry-report/the-psychopharmacology-algorithm-project/)," The Carlat Psychiatry Report, April 2020

Got feedback? Take the podcast survey. (https://www.thecarlatreport.com/podcastsurvey/)

We speak with David Osser, whose psychopharmacology algorithm project challenges many conventions about psychiatric medications. When antidepressants cause more depression. Psychotic disorders that don't respond to antipsychotics. When to trust the evidence, and what to do with clinical experience.

Published on: 4/13/20

Duration: 18 minutes, 56 seconds

Related Articles: "The Psychopharmacology Algorithm Project (https://www.thecarlatreport.com/the-carlat-psychiatry-report/the-psychopharmacology-algorithm-project/)," The Carlat Psychiatry Report, April 2020

Got feedback? Take the podcast survey. (https://www.thecarlatreport.com/podcastsurvey/)