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In this episode of the Incubator, Betsy Crouch and David McCulley interview Dr. Wendy Chung, a leader in clinical genetics and child health research. They discuss her journey into genomics, the challenges faced in her career as a physician scientist, the importance of early mentorship, and her research interests, particularly in congenital diaphragmatic hernia (CDH). Dr. Chung shares insights on the complexities of genetic disorders and the need for innovative approaches in treatment and diagnosis. She discusses her experiences with newborn screening and the evolution of genetic screening for rare diseases, emphasizing the importance of advocacy for children's health research. The conversation highlights the impact of patient stories in research and concludes with personal insights into family activities and the importance of maintaining a balance between work and personal life.

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As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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In this episode of The Incubator Podcast, renowned neonatologist and researcher Dr. Keith Barrington discusses his career, his influential blog (Neonatal Research), and his contributions to evidence-based neonatology. Dr. Barrington explains how his blog originated from sharing recent research insights with trainees and grew into a platform that educates professionals and promotes consistent, evidence-based practices in neonatology. He emphasizes the importance of critically evaluating new studies and their potential impact on clinical care.

The conversation also explores his personal journey as the father of a 24-week premature baby, Violette. This experience shaped his understanding of parental perspectives and the challenges families face in the NICU. He highlights the need for healthcare providers to align clinical decisions with what parents deem acceptable outcomes, emphasizing compassion and humility in predicting long-term results.

Dr. Barrington reflects on the future of neonatology, stressing the importance of reducing variations in care across centers and leveraging multi-center networks to optimize outcomes. He advocates for innovative research approaches, such as registry-based trials, to address challenges in studying rare neonatal conditions. Throughout the episode, his passion for improving neonatal care through science and empathy shines through.

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As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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In this episode of the Global Neonatal Podcast, Dr. Msandeni Chiume-Kayuni shares her inspiring journey into pediatrics and neonatal health in Malawi. As the chief pediatrician for Malawi's Ministry of Health, she discusses the significant strides made in neonatal survival, the importance of data collection, and the role of partnerships in improving healthcare outcomes. Dr. Msandeni emphasizes the need for infrastructure and human resources in neonatal care and shares valuable insights on how clinicians can be the change they wish to see in their communities.

Contact:  [email protected]

Episode Webpage Link: https://www.the-incubator.org/post/270-championing-neonatal-health-in-malawi-a-pediatrician-s-inspiring-journey-ft-dr-msandeni

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As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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In this engaging Journal Club episode, Ben and Daphna return to explore the latest research in neonatology. They begin with a pivotal clinical report from Pediatrics on updated algorithms for newborn screening of critical congenital heart disease (CCHD), highlighting simplified protocols and their significant impact on infant mortality. The discussion delves into screening challenges in the NICU, high-altitude settings, and for out-of-hospital births.

Next, they discuss the CordSafe study from Australia, a phase 1 trial on the safety of autologous cord blood-derived cell administration for extremely preterm infants, aimed at reducing brain injuries like IVH. Daphna explains the rigorous methodology and promising early findings.

Ben then reviews the STAT trial, which evaluates whether primary anastomosis offers better outcomes than stoma formation in NEC surgery. The results show significant reductions in TPN duration and intestinal complications with primary anastomosis.

The hosts also discuss trends in PDA management and their surprising association with increased rates of BPD over the past decade, along with insights into evolving diagnostic and therapeutic practices.

Finally, they analyze a Spanish study on elective extubation during skin-to-skin care, finding it to be a feasible and safe practice, potentially enhancing neonatal and parental outcomes.

Don’t miss next week’s exciting interview with Dr. Keith Barrington!

Support the show

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Elective extubation during skin-to-skin care in preterm newborns is safe and well-tolerated.

Morey-Olivé M, Romaní-Franquesa N, Echeverría-Gallart M, Céspedes-Dominguez MC, Camba-Longueira F, Montaner-Ramon A.Acta Paediatr. 2024 Nov 12. doi: 10.1111/apa.17496. Online ahead of print.PMID: 39530316

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As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Occurrence and Time of Onset of Intraventricular Hemorrhage in Preterm Neonates: A Systematic Review and Meta-Analysis of Individual Patient Data.

Nagy Z, Obeidat M, Máté V, et al. JAMA Pediatr. 2024 Dec.

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As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Changes in Patent Ductus Arteriosus Management and Outcomes in Infants Born at 26 to 28 Weeks' Gestation.

Kaluarachchi DC, Rysavy MA, Do B, Chock VY, Laughon MM, Backes CH, Colaizy TT, Bell EF, McNamara PJ.J Pediatr. 2024 Dec 26:114456. doi: 10.1016/j.jpeds.2024.114456. Online ahead of print.PMID: 39732160

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As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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STAT trial: stoma or intestinal anastomosis for necrotizing enterocolitis: a multicentre randomized controlled trial.

Eaton S, Ganji N, Thyoka M, Shahroor M, Zani A, Pleasants-Terashita H, Ghazzaoui AE, Sivaraj J, Loukogeorgakis S, De Coppi P, Montedonico S, Sindjic-Antunovic S, Lukac M, Hamill J, Choo CSC, Nah SA, Hulscher J, Emil S, Petersen A, Wijnen R, Sloots C, Sigalet D, Kiely E, Svensson JF, Wester T, Pierro A.Pediatr Surg Int. 2024 Oct 29;40(1):279. doi: 10.1007/s00383-024-05853-3.PMID: 39470842 Free PMC article. Clinical Trial.

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As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Feasibility and safety of autologous cord blood derived cell administration in extremely preterm infants: a single-centre, open-label, single-arm, phase I trial (CORD-SaFe study).

Zhou L, McDonald CA, Yawno T, Razak A, Connelly K, Novak I, Miller SL, Jenkin G, Malhotra A.EBioMedicine. 2024 Dec 13;111:105492. doi: 10.1016/j.ebiom.2024.105492. Online ahead of print.PMID: 39674685 Free article.

Support the show

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Newborn Screening for Critical Congenital Heart Disease: A New Algorithm and Other Updated Recommendations: Clinical Report.

Oster ME, Pinto NM, Pramanik AK, Markowsky A, Schwartz BN, Kemper AR, Hom LA, Martin GR; and the SECTION ON CARDIOLOGY AND CARDIAC SURGERY; SECTION ON HOSPITAL MEDICINE; COMMITTEE ON FETUS AND NEWBORN.Pediatrics. 2025 Jan 1;155(1):e2024069667. doi: 10.1542/peds.2024-069667.PMID: 39679594

Support the show

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!