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In this episode of The Incubator Podcast Journal Club, Ben and Daphna explore a range of insightful articles that challenge current neonatal care practices. They begin by introducing an exciting new series called "From the Heart," focusing on cardiac journal reviews. Special guests from the EBNEO team join the discussion to dive into a recent trial on oxygen use in delivery room resuscitations for preterm infants. The hosts also examine a trial that investigates the impact of lung recruitment maneuvers before surfactant administration in extremely preterm neonates, exploring whether these techniques could reduce the need for mechanical ventilation.

This episode provides in-depth analysis and a balanced discussion about the implications of these findings for everyday neonatal care. With guest appearances from Dr. Abdul Razak and Dr. Kiran Srivastava, the team also debates the latest meta-analysis on initial oxygen concentrations during neonatal resuscitation, offering fresh perspectives on potential changes in clinical practice. Whether you're interested in innovative resuscitation techniques or curious about how recent studies may shape the future of neonatal care, this episode offers thought-provoking insights that every NICU professional should hear.

Support the show

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Lung recruitment before surfactant administration in extremely preterm neonates with respiratory distress syndrome (IN-REC-SUR-E): a randomised, unblinded, controlled trial.

Vento G, Ventura ML, Pastorino R, van Kaam AH, Carnielli V, Cools F, Dani C, Mosca F, Polglase G, Tagliabue P, Boni L, Cota F, Tana M, Tirone C, Aurilia C, Lio A, Costa S, D'Andrea V, Lucente M, Nigro G, Giordano L, Roma V, Villani PE, Fusco FP, Fasolato V, Colnaghi MR, Matassa PG, Vendettuoli V, Poggi C, Del Vecchio A, Petrillo F, Betta P, Mattia C, Garani G, Solinas A, Gitto E, Salvo V, Gargano G, Balestri E, Sandri F, Mescoli G, Martinelli S, Ilardi L, Ciarmoli E, Di Fabio S, Maranella E, Grassia C, Ausanio G, Rossi V, Motta A, Tina LG, Maiolo K, Nobile S, Messner H, Staffler A, Ferrero F, Stasi I, Pieragostini L, Mondello I, Haass C, Consigli C, Vedovato S, Grison A, Maffei G, Presta G, Perniola R, Vitaliti M, Re MP, De Curtis M, Cardilli V, Lago P, Tormena F, Orfeo L, Gizzi C, Massenzi L, Gazzolo D, Strozzi MCM, Bottino R, Pontiggia F, Berardi A, Guidotti I, Cacace C, Meli V, Quartulli L, Scorrano A, Casati A, Grappone L, Pillow JJ.Lancet Respir Med. 2021 Feb;9(2):159-166. doi: 10.1016/S2213-2600(20)30179-X. Epub 2020 Jul 17.PMID: 32687801 Clinical Trial.

Lung Recruitment Before Surfactant Administration in Extremely Preterm Neonates: 2-Year Follow-Up of a Randomized Clinical Trial.

Gallini F, De Rose DU, Iuliano R, Romeo DM, Tana M, Paladini A, Fusco FP, Nobile S, Cota F, Tirone C, Aurilia C, Lio A, Esposito A, Costa S, D'Andrea V, Ventura ML, Carnielli V, Dani C, Mosca F, Fumagalli M, Scarpelli G, Giordano L, Fasolato V, Petrillo F, Betta P, Solinas A, Gitto E, Gargano G, Mescoli G, Martinelli S, Di Fabio S, Bernardo I, Tina LG, Staffler A, Stasi I, Mondello I, Scapillati E, Vedovato S, Maffei G, Bove A, Vitaliti M, Terrin G, Lago P, Gizzi C, Strozzi C, Villani PE, Berardi A, Cacace C, Bracaglia G, Pascucci E, Cools F, Pillow JJ, Polglase G, Pastorino R, van Kaam AH, Mercuri E, Orfeo L, Vento G; IN-REC-SUR-E Study Group; Malguzzi S, Rigotti C, Cecchi A, Nigro G, Costabile CD, Roma E, Sindico P, Venafra R, Mattia C, Conversano M, Ballardini E, Manganaro A, Balestri E, Gallo C, Catenazzi P, Astori MG, Maranella E, Grassia C, Maiolo K, Castellano D, Massenzi L, Chiodin E, Gallina MR, Consigli C, Sorrentino E, Bonato S, Mancini M, Perniola R, Giannuzzo S, Tranchina E, Cardilli V, Dito L, Regoli D, Tormena F, Battajon N, Arena R, Allais B, Guidotti I, Roversi F, Meli V, Tulino V, Casati A.JAMA Netw Open. 2024 Sep 3;7(9):e2435347. doi: 10.1001/jamanetworkopen.2024.35347.PMID: 39320892 Free PMC article. Clinical Trial.

Support the show

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Antenatal magnesium sulphate reduces cerebral palsy after preterm birth, implementation into clinical practice needs to be accelerated globally to benefit preterm babies.

Luyt K.Cochrane Database Syst Rev. 2024 Sep 24;9:ED000168. doi: 10.1002/14651858.ED000168.PMID: 39315530 No abstract available.

Support the show

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Initial Oxygen Concentration for the Resuscitation of Infants Born at Less Than 32 Weeks' Gestation: A Systematic Review and Individual Participant Data Network Meta-Analysis.

Sotiropoulos JX, Oei JL, Schmölzer GM, Libesman S, Hunter KE, Williams JG, Webster AC, Vento M, Kapadia V, Rabi Y, Dekker J, Vermeulen MJ, Sundaram V, Kumar P, Kaban RK, Rohsiswatmo R, Saugstad OD, Seidler AL.JAMA Pediatr. 2024 Aug 1;178(8):774-783. doi: 10.1001/jamapediatrics.2024.1848.PMID: 38913382

Support the show

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Validation of a machine learning algorithm for identifying infants at risk of hypoxic ischaemic encephalopathy in a large unseen data set.

Murray AL, O'Boyle DS, Walsh BH, Murray DM.Arch Dis Child Fetal Neonatal Ed. 2024 Sep 24:fetalneonatal-2024-327366. doi: 10.1136/archdischild-2024-327366. Online ahead of print.PMID: 39251344

Support the show

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Blood volume collected for cultures in infants with suspected neonatal sepsis.

Rueda MS, Soghier L, Campos J, Bahar B, Bost JE, Gai J, Hamdy RF.J Perinatol. 2024 Sep 28. doi: 10.1038/s41372-024-02120-0. Online ahead of print.PMID: 39341980

Support the show

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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In this episode of Tech Tuesday on The Incubator Podcast, hosted by Daphna, Mark O'Sullivan, PhD, CEO, and co-founder of NeuroBell, discusses their cutting-edge medical device aimed at improving neonatal seizure detection. NeuroBell, a spinoff from the Infant Research Center at University College Cork, has developed a pocket-sized, wireless EEG monitor equipped with AI-based seizure detection for newborns. This device is designed to be user-friendly for bedside staff and eliminates the need for extensive EEG training, making it accessible in hospitals with limited EEG resources.

Mark shares the story behind the development of the device, highlighting the challenges of acquiring EEG data due to its small signal and the importance of minimizing seizure burden in newborns. He explains how the device addresses gaps in care by providing real-time seizure detection in settings where traditional EEG monitoring might not be readily available.

Currently in clinical trials in Ireland and the U.S., NeuroBell aims to provide a streamlined solution that could be particularly useful in community hospitals and smaller settings. The episode wraps up with Mark's vision for the future of NeuroBell, which includes FDA submission and market release in 2025.

Support the show

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!

Send us Fan Mail

In this special episode of The Incubator podcast, Ben and Daphna wrap up the 2024 Delphi Neonatal Innovation Conference, sharing their favorite moments and highlights. This episode features the exclusive audio from four captivating Delphi talks. Dr. Suresh Gautham, Chair of Pediatrics at Nemours Children's Hospital, opens with an intriguing talk on "What Neonatologists Can Learn from Sherlock Holmes," drawing parallels between neonatal practice and detective work. Dr. Terrie Inder from CHOC delivers insights in "The Science and Art of Improving Neurological Outcomes in NICU Graduates," blending research with practical care strategies. Pediatric nephrologist Chryso Pefkaros Katsoufis from the University of Miami explores "The Road Less Traveled? Neonatal Biomarkers of Chronic Kidney Disease," shedding light on innovative approaches to CKD in newborns. Finally, Dr. Lauren Ruoss, from Winnie Palmer Hospital, enchants the audience with "Abracadabra! Making POCUS Appear in the NICU," detailing the role of point-of-care ultrasound in neonatal care. Ben and Daphna conclude the episode by previewing exciting upcoming developments for The Incubator network. Don’t miss this unique opportunity to hear from some of the leading voices in neonatal care.

Support the show

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!

Send us Fan Mail

In this special episode of The Incubator podcast, Ben and Daphna wrap up the 2024 Delphi Neonatal Innovation Conference, sharing their favorite moments and highlights. This episode features the exclusive audio from four captivating Delphi talks. Dr. Suresh Gautham, Chair of Pediatrics at Nemours Children's Hospital, opens with an intriguing talk on "What Neonatologists Can Learn from Sherlock Holmes," drawing parallels between neonatal practice and detective work. Dr. Terrie Inder from CHOC delivers insights in "The Science and Art of Improving Neurological Outcomes in NICU Graduates," blending research with practical care strategies. Pediatric nephrologist Chryso Pefkaros Katsoufis from the University of Miami explores "The Road Less Traveled? Neonatal Biomarkers of Chronic Kidney Disease," shedding light on innovative approaches to CKD in newborns. Finally, Dr. Lauren Ruoss, from Winnie Palmer Hospital, enchants the audience with "Abracadabra! Making POCUS Appear in the NICU," detailing the role of point-of-care ultrasound in neonatal care. Ben and Daphna conclude the episode by previewing exciting upcoming developments for The Incubator network. Don’t miss this unique opportunity to hear from some of the leading voices in neonatal care.

Support the show

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!

Send us Fan Mail

In this special episode of The Incubator podcast, Ben and Daphna wrap up the 2024 Delphi Neonatal Innovation Conference, sharing their favorite moments and highlights. This episode features the exclusive audio from four captivating Delphi talks. Dr. Suresh Gautham, Chair of Pediatrics at Nemours Children's Hospital, opens with an intriguing talk on "What Neonatologists Can Learn from Sherlock Holmes," drawing parallels between neonatal practice and detective work. Dr. Terrie Inder from CHOC delivers insights in "The Science and Art of Improving Neurological Outcomes in NICU Graduates," blending research with practical care strategies. Pediatric nephrologist Chryso Pefkaros Katsoufis from the University of Miami explores "The Road Less Traveled? Neonatal Biomarkers of Chronic Kidney Disease," shedding light on innovative approaches to CKD in newborns. Finally, Dr. Lauren Ruoss, from Winnie Palmer Hospital, enchants the audience with "Abracadabra! Making POCUS Appear in the NICU," detailing the role of point-of-care ultrasound in neonatal care. Ben and Daphna conclude the episode by previewing exciting upcoming developments for The Incubator network. Don’t miss this unique opportunity to hear from some of the leading voices in neonatal care.

Support the show

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!