The Incubator

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Variability of Care Practices for Extremely Early Deliveries.

LoRe D, Groden CM, Schuh AR, Holmes C, Ostilla L, Vogel MM, Murray PD, Yamasato K, Tonismae T, Anani UE, Henner N, Famuyide M, Leuthner SR, Laventhal N, Andrews BL, Tucker Edmonds BM, Brennan KG, Feltman DM; INVESTIGATING NEONATAL DECISIONS FOR EXTREMELY EARLY DELIVERIES (INDEED) STUDY GROUP.Pediatrics. 2024 Aug 12:e2023065521. doi: 10.1542/peds.2023-065521. 

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As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Effects of a live versus heat-inactivated probiotic Bifidobacterium spp in preterm infants: a randomised clinical trial.

Athalye-Jape G, Esvaran M, Patole S, Nathan EA, Doherty DA, Sim E, Chandrasekaran L, Kok C, Schuster S, Conway P.Arch Dis Child Fetal Neonatal Ed. 2024 Aug 17:fetalneonatal-2023-326667. doi: 10.1136/archdischild-2023-326667. 

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As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Dr. Steve McElroy, a neonatologist and physician scientist, discusses his research on injury and repair mechanisms in the immature intestine, specifically focusing on necrotizing enterocolitis (NEC) and spontaneous intestinal perforation in premature infants. He shares his journey from initially not wanting to pursue science to becoming a physician scientist, and how mentorship played a crucial role in his career. Dr. McElroy also talks about his pioneering work on Paneth cells and the Paneth cell ablation NEC model. He highlights the importance of listening, asking questions, and being open to new research directions. Finally, he discusses the impact of his leadership role as a division chief on his research and mentorship activities. He emphasizes the importance of mentorship, celebrating small victories, and persisting through challenges. Dr. McElroy also shares insights into his current research on chorioamnionitis and its impact on neonatal health. He highlights the need for creative think time and the value of understanding mechanisms in basic science. The conversation concludes with a discussion on building a supportive and fun lab environment.

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As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Gear up for a groundbreaking event in neonatal care! The Delphi Neonatal Innovation Conference is set to take Fort Lauderdale by storm from September 23-25. Hosted by Ben Courchia and Daphna Yasova Barbeau from the Incubator podcast, this conference promises a unique blend of cutting-edge content and networking opportunities.

Highlights include three free workshops: Point-of-Care Ultrasound with state-of-the-art equipment, Artificial Intelligence in Neonatology, and Narrative Medicine. The event features exciting pitch presentations showcasing innovative neonatal technologies, from synchronized high-flow nasal cannula to wearable phototherapy devices.

Don't miss the fellowship trivia competition, offering a chance to win an educational grant. The conference also includes a special TEDx event with prestigious speakers discussing topics ranging from environmental impacts on perinatal outcomes to creativity within limitations.

An evening of powerful storytelling by NICU professionals promises to be a moving experience. For those unable to attend in person, high-quality live streaming is available.

With its focus on practical innovation and networking, the Delphi Neonatal Innovation Conference is set to be an unmissable event for anyone passionate about advancing neonatal care. Register now to be part of this transformative experience!

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As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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In this episode of The Incubator podcast, hosts Ben Courchia and Daphna Barbeau welcome Dr. David Askenazi and Dr. Tara Beck to discuss neonatal nephrology. The conversation explores the challenges of defining and diagnosing acute kidney injury (AKI) in newborns, highlighting the variability in nephron numbers at birth and the complexities of interpreting creatinine levels in the first days of life.

The guests discuss the long-term effects of neonatal AKI, the importance of follow-up care, and strategies for supporting kidney health in the NICU and beyond. They emphasize the need for a partnership between neonatology and nephrology to improve outcomes.

Dr. Askenazi introduces the Neonatal Kidney Collaborative (NKC), explaining its mission to advance research, education, and advocacy in neonatal nephrology. Dr. Beck shares her experience as a trainee involved with the NKC, highlighting the mentorship opportunities available.

The episode concludes with a look towards the future of neonatal nephrology research, including potential therapies and the evolving approach to renal replacement therapy in newborns. This informative discussion provides valuable insights for both neonatologists and nephrologists caring for vulnerable newborns.

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As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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In this episode of The Incubator podcast, hosts Ben Courchia and Daphna Barbeau welcome Dr. David Askenazi and Dr. Tara Beck to discuss neonatal nephrology. The conversation explores the challenges of defining and diagnosing acute kidney injury (AKI) in newborns, highlighting the variability in nephron numbers at birth and the complexities of interpreting creatinine levels in the first days of life.

The guests discuss the long-term effects of neonatal AKI, the importance of follow-up care, and strategies for supporting kidney health in the NICU and beyond. They emphasize the need for a partnership between neonatology and nephrology to improve outcomes.

Dr. Askenazi introduces the Neonatal Kidney Collaborative (NKC), explaining its mission to advance research, education, and advocacy in neonatal nephrology. Dr. Beck shares her experience as a trainee involved with the NKC, highlighting the mentorship opportunities available.

The episode concludes with a look towards the future of neonatal nephrology research, including potential therapies and the evolving approach to renal replacement therapy in newborns. This informative discussion provides valuable insights for both neonatologists and nephrologists caring for vulnerable newborns.

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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In this episode of Journal Club, hosts Ben and Daphna dive into several impactful studies in neonatology. They begin with a series of papers on patent ductus arteriosus (PDA) management, discussing pharmacological treatments, transcatheter closure techniques, and new clinical practice guidelines. The conversation highlights the evolving landscape of PDA treatment and the need for more robust research.

The hosts also explore a study on diazoxide for neonatal hypoglycemia, examining its effects on glycemic stability and feeding outcomes. They discuss recent findings on infant mortality rates in Texas following abortion restrictions, emphasizing the impact of policy changes on neonatal health outcomes.

Additionally, the episode covers a systematic review of quality improvement interventions to prevent intraventricular hemorrhage in preterm infants, highlighting the complexity of implementing effective "neurobundles".

The hosts conclude with a study on vasopressin as an adjunctive therapy for pulmonary hypertension in term newborns, noting its potential benefits in improving oxygenation and hemodynamic status.

Throughout the episode, Ben and Daphna provide insightful commentary on the clinical implications of these studies, making complex research accessible to listeners while emphasizing the need for continued investigation in key areas of neonatal care.

Support the show

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Diazoxide for Severe or Recurrent Neonatal Hypoglycemia: A Randomized Clinical Trial.

Laing D, Walsh EPG, Alsweiler JM, Hanning SM, Meyer MP, Ardern J, Cutfield WS, Rogers J, Gamble GD, Chase JG, Harding JE, McKinlay CJD.JAMA Netw Open. 2024 Jun 3;7(6):e2415764. doi: 10.1001/jamanetworkopen.2024.15764.PMID: 38869900 Free PMC article. Clinical Trial.

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As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Vasopressin as adjunctive therapy in pulmonary hypertension associated with refractory systemic hypotension in term newborns.

Santelices F, Masoli D, Kattan J, Toso A, Luco M.J Perinatol. 2024 Jul 4. doi: 10.1038/s41372-024-02015-0. Online ahead of print.PMID: 38965377

Support the show

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

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Procedural closure of the patent ductus arteriosus in preterm infants: a clinical practice guideline.

Mitra S, Bischoff AR, Sathanandam S, Lakshminrusimha S, McNamara PJ.J Perinatol. 2024 Jul 12. doi: 10.1038/s41372-024-02052-9. Online ahead of print.PMID: 38997403 Review.

Support the show

As always, feel free to send us questions, comments, or suggestions to our email: [email protected]. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.

Enjoy!