Jim Al-Khalili talks T cells, our immune response and Long Covid with Prof Danny Altmann.

Danny Altmann joined ‘team T cells’ in his twenties and has been studying how these killer operate ever since. How do they know which cells to search and destroy?

Danny tells Jim how he came to study our immune response to all sorts of pathogens, from anthrax to zika, why he spends every morning from 5 to 6am in the bath reading 19th century classics and why he’s determined to try and understand Long Covid.

Jim Al-Khalili talks to astrophysicist Haley Gomez about defying expectations and becoming a world expert on cosmic dust.

For centuries, cosmic dust was a major source of irritation to optical astronomers because, like smog, it stopped them from seeing the stars. Now studies of these tiny particles are challenging some deeply held assumptions about the physics of the universe.

Haley’s research has changed the textbook explanation of how cosmic dust is formed and helped to open our eyes to just how many galaxies there are in the universe.

In 2018 she was awarded an MBE for services to physics and inspiring the next generation of physicists and astronomers from less privileged communities. A cause which is very close to her heart.

Produced by Anna Buckley and recorded in the Pier Head Building in Cardiff as part of the Cardiff Science Festival.

How a once-derided approach to statistics paved the way for AI. Jim Al-Khalili talks to pioneering mathematician, Professor Sir Adrian Smith.

Accused early in his career of ‘trying to destroy the processes of science’, Adrian went on to prove that a branch of statistics (invented by the Reverend Thomas Bayes in 1764) could be used by computers to analyse vast sets of data and to learn from that data.

His mathematical proofs showed that Bayesian statistics could be applied to all sorts of real world problems: from improving survival rates for kidney transplant patients to tracking Russian submarines. And paved the way for a dramatic explosion in machine learning and AI.

Working as a civil servant (2008-2012) he helped to protect the science budget in 2010, transforming the landscape for scientific research in the UK. And he has been vocal, over many years, about the urgent need to make sure children in the UK leave school more mathematically able.

In 2020, he became President of the UK's prestigious national science academy, The Royal Society.

Clifford Johnson's career to date has spanned some seemingly very different industries - from exploring quantum mechanics around string theory and black holes, to consulting on some of Hollywood's biggest movies; but it makes sense once you understand his ambition of making science accessible to all.

Produced by Lucy Taylor.

A fur-stripped mouse carcase might not sound like the cosiest of homes – but that’s where the burying beetle makes its nest; and where Rebecca Kilner has focused much of her research.

Producer: Lucy Taylor

Motor Neuron Disease (MND) is a degenerative disease that relentlessly attacks the human nervous system, deteriorating muscle function to the point where patients can no longer move, talk, eat, or even breathe.

To date there’s no cure, and until fairly recently there were only minimal treatments to ease the symptoms.

Pam Shaw has dedicated her career to changing that.

A Professor of Neurology at Sheffield University and Founding Director of the Sheffield Institute for Translational Neuroscience, she recently led clinical trials into a drug that delivered unprecedented results: showing that it could slow the progression of MND in certain patients, and even improve symptoms for some.

It’s just one small step – but with a new tranche of research funding and a national institute to study the disease on the cards, Pamela believes this could be the start of real progress in understanding and treating Motor Neuron Disease.

Producer: Lucy Taylor

Professor Chris Elliott is something of a ‘food detective’.

Following the 2013 horse meat scandal – when prepared foods purporting to be made from beef were found to contain undeclared horse-meat – Chris conducted the independent review of the UK food system that brought to light the growing threat of food crime. Since then, his name’s become synonymous with solving cases of food fraud; today he receives regular tip-offs on everything from oregano scams to dodgy potatoes.

But as Chris tells Jim Al-Khalili, his team at the IGFS are pioneering new techniques to read the molecular fingerprint of foodstuffs, with technology that they hope will stop the fraudsters in their tracks…

Producer: Lucy Taylor

What use to science is a pesky organism that feeds on rotting fruit? Professor Bambos Kyriacou has spent fifty years observing the behaviour of fruit flies. He keeps them in the lab and in his garden in their thousands, has recorded fruit fly courtship songs using a microphone loved by Jonny Carson (because it made his voice sound deeper) and invented equipment to keep track of their sleeping patterns. He tells Jim Al-Khalili how fruit flies sparked his interest in genetics and how experiments with insomniac fruit flies opened our eyes to the fundamental importance of body clocks.

Leon Barron monitors pollution in our rivers, keeping tabs on chemicals that could be harmful to the environment and to our health. He’s also gathered intelligence on the behaviour of millions of Londoners by studying the water we flush down the loo. His analysis of sewage revealed, for example, just how much cocaine is consumed in London every day. And he’s helped the Metropolitan Police to crack crimes in other ways too, inventing new chemistry tools that can be used by forensic scientists to uncover clues. At school he had no idea he wanted to be an analytical chemist but a short work experience placement at the fertiliser factory convinced him that this kind of detective work was fun.

Tim Lamont is a young scientist making waves. Arriving on the Great Barrier Reef after a mass bleaching event, Tim saw his research plans disappear and was personally devastated by the destruction. But from that event he discovered a novel way to restore coral reefs. Playing the sounds of a healthy coral reef entices fish in to recolonise the wrecked reefs. Tim's emotional journey forced him to realise that environmental scientists can no longer just observe. They need to find new prisms with which to view the world and to intervene to save or protect the natural environment.