ZOE Science & Nutrition

The surprising truth about histamine intolerance


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We've probably all heard of “antihistamines,” medications that can ease symptoms of hay fever and other allergies. 

But what is “histamine”? It’s a vital chemical that our bodies produce, and it plays a role in a number of functions that support our health. 

Histamine intolerance seems to be increasingly common, but it’s difficult to diagnose. Some people may not be aware that they have it or how to treat it.

In today’s episode of ZOE Science & Nutrition, Jonathan speaks with Dr. Will Bulsiewicz, ZOE’s U.S. medical director, to learn more about this flourishing area of research — and the best ways to identify and treat histamine intolerance.

Will is a board-certified gastroenterologist, and New York Times bestselling author of the microbiome book Fiber Fueled.

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Mentioned in today’s episode: 

  • Resistant potato starch supplementation reduces serum histamine levels in healthy adults with links to attenuated intestinal permeability published in Journal of Functional Foods
  • Histamine and histamine intolerance published in The American Journal of Clinical Nutrition
  • Histamine intolerance: The current state of the art published in Biomolecules


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    Episode transcripts are available here.

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