We kick this one off the way we always do — just talking. Paul's lupus is somehow in the best shape it's ever been despite a stretch of travel, stress, and general chaos, which honestly tracks.
He also got a new puppy named Charlie — a supposedly golden retriever who came out black, so there are some questions there.
I'm reading my first fiction book in years (Dungeon Crawler Carl, it's actually great), heading to Vancouver to see my girlfriend, and planning a trip back to Connecticut to see family and let my mom dye my hair icy blonde. Normal stuff.
Then we get into the actual topic: GLP-1 medications. These things are everywhere right now — Ozempic, Wegovy, Mounjaro — and whether you're curious, currently using one, or coaching someone who is, this episode is worth your time.
Paul did his research (he called it extensive, I'll let you be the judge), and we break down what GLP-1s actually are, what glucagon-like peptide-1 does in the body, and why these medications work across multiple pathways — not just appetite suppression.
We talk about who actually benefits from GLP-1s, because it's not a blanket answer. We get into food noise — that constant mental chatter around food that a lot of people don't even realize they have until it goes quiet — and why that alone can be life-changing for certain people.
We also get real about the risks, the cost reality (most people are paying out of pocket), the side effects, and what the research actually shows versus what's being hyped on social media.
The part I think matters most: what happens when you come off them. This is where lifestyle, meal structure, and habits become non-negotiable.
The medication quiets hunger — it doesn't build the skills. That part is still on you. We talk through how we approach this with our own clients and what the off-ramp actually looks like when it's done right.
Paul's IG: @paulbuono
Chapters
00:00 Introduction and Personal Updates
07:27 Understanding GOP-1 Medications
20:06 Who Can Benefit from GOP-1s?
22:27 The Importance of Lifestyle Changes with GOP-1s
26:25 Understanding Food Noise and Its Implications
27:28 Risks and Considerations of GLP-1 Medications
29:53 When to Consider Coming Off GLP-1 Medications
32:53 Side Effects and Management of GLP-1 Medications
36:42 Preparing for Life After GLP-1 Medications
42:24 Personal Updates and Future Plans
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