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GLP-1 agonists in HFpEF, DOACs for subclinical AF, renal denervation, and the matter of remaining in the profession are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Obesity and HFpEF
GLP-1 Agonists in HFpEF With Obesity: Are We There Yet? https://www.medscape.com/viewarticle/993980
Wegovy Scores HFpEF Benefits in People With Obesity https://www.medscape.com/viewarticle/995844
- Semaglutide in Obese Patients With HFpEF https://www.nejm.org/doi/full/10.1056/NEJMoa2306963
- Rationale/Protocol Paper https://doi.org/10.1016/j.jchf.2023.05.010
II. DOAC for Subclinical AF
- NOAH-AFNET 6 Rationale/Protocol https://doi.org/10.1016/j.ahj.2017.04.015
- NOAH-AFNET 6 Trial Results https://www.nejm.org/search?q=NOAH+AFNET
III. Renal Denervation
ReCor Renal Denervation System Safe, Effective: FDA Panel https://www.medscape.com/viewarticle/995741
FDA Panel Split on Efficacy of Spyral Renal Denervation https://www.medscape.com/viewarticle/995800
SPYRAL HTN-ON MED https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00455-X/fulltext
IV. Maintenance of Certification
As MOC Debate Heats Up, Cardiology Societies Weigh In https://www.medscape.com/viewarticle/moc-debate-heated-cardiology-societies-weigh-2023a1000jju
Features
Mandrola's 5 Things to Look for at the Upcoming ESC 2023
https://www.medscape.com/viewarticle/995614
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https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact: [email protected]
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
ICD generator change, less is more in VT management, co-morbidity in HF, and SGLT2i after AF ablation are the topics discussed by John Mandrola, MD, in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. ICD Gen Change
- Patients' Perspectives Regarding Generator Exchanges of Implantable Cardioverter Defibrillators https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.122.009827
- DEFINITE https://www.nejm.org/doi/10.1056/nejmoa033088
- SCD-HeFT https://www.nejm.org/doi/full/10.1056/nejmoa043399
- DANISH https://www.nejm.org/doi/10.1056/NEJMoa1608029
- Poole and colleagues; 11-year follow-up of SCD-HeFT https://doi.org/10.1016/j.jacc.2020.05.061
- Editorial – Howell/Stecker https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.123.010266
II. VT Therapy
Crossed Wires: Ischemia Testing and Monomorphic VT Storm
https://www.medscape.com/viewarticle/995401
- Cleveland Clinic Study
https://doi.org/10.1016/j.jacep.2023.04.030
III. Co-Morbidity in HF
- Hospital admissions in the last year of life of patients with heart failure
https://doi.org/10.1093/ehjqcco/qcad047
- Four Horsemen of Apocalypse Lecture
http://www.louisvillelectures.org/imblog/2017/10/5/whw8sf0m1k0wi6lm6kvjsx4nxzzjg5
IV. SGLT2i After Ablation for AF
SGLT2 Inhibitors Curb AF Post-Ablation Recurrences in Diabetes
https://www.medscape.com/viewarticle/995415
- Observational Study – Abu-Qaoud et al
https://www.jacc.org/doi/full/10.1016/j.jacep.2023.06.008
- Meta-analysis SGLT2i and AF
https://www.ahajournals.org/doi/full/10.1161/JAHA.121.022222
You may also like:
Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine
https://www.medscape.com/features/public/machine
The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD.
https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact [email protected]
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Observational studies, another defense of digoxin, CTO-PCI, BP measurement, and a possible revolution in cardiovascular protection are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Observational Research
Yeh; Credibility in Observational Research https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064645
Hernan; Causal Language in Observational Research https://ajph.aphapublications.org/doi/full/10.2105/AJPH.2018.304337
Wang; RCT Duplicate Initiative https://jamanetwork.com/journals/jama/fullarticle/2804067
II. Defense of Digoxin
Brophy; Beta Blockers, Digoxin, or Both https://doi.org/10.1016/j.cjca.2023.06.009
Dorian editorial https://doi.org/10.1016/j.cjca.2023.07.013
Ziff Digoxin Meta-analysis https://www.bmj.com/content/351/bmj.h4451.long
DIG trial https://www.nejm.org/doi/full/10.1056/nejm199702203360801
Davila Analysis of DIG Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801940/
Kotecha Meta-analysis of Beta Blockers https://pubmed.ncbi.nlm.nih.gov/25193873/
RATE-AF https://jamanetwork.com/journals/jama/fullarticle/2774407
III. CTO-PCI
PCI of Chronic Total Occlusions Improves Angina, Quality of Life in Trials https://www.medscape.com/viewarticle/994739
JAMA Network Open Meta-analysis
IV. BP Measurement
One Size Doesn't Fit All in Blood Pressure Measurement https://www.medscape.com/viewarticle/995216
Ishigami Blood Pressure Measurement Comparison
https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2807853
V. GLP-1 SELECT Trial
Semaglutide Cuts Cardiovascular Events in Landmark Trial
https://www.medscape.com/viewarticle/995270
SELECT Protocol Paper
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The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD.
https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact [email protected]
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Listener feedback re observational studies, surgeons' dissent from recent guidelines, aspirin for primary prevention, and fish oil are the topics discussed by John Mandrola.MD in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Heart Surgeons Dissent
Surgical Groups Push Back Against New Revascularization Guidelines
https://www.medscape.com/viewarticle/966153
New Revascularization Guidelines: Key Points and Navigating Controversies
https://www.medscape.com/viewarticle/972014
- AHA Guidelines - https://doi.org/10.1161/CIR.0000000000001168
- AATS statement 2023 https://doi.org/10.1016/j.jtcvs.2023.03.001
- Yusef and colleagues 1994 Meta-analysis - https://doi.org/10.1016/S0140-6736(94)91963-1
- 10-year SYNTAXES https://doi.org/10.1016/S0140-6736(19)31997-X
- Surgeons' argument 2021 https://doi.org/10.1016/j.athoracsur.2021.12.003
- FAME 3 https://www.nejm.org/doi/full/10.1056/NEJMoa2112299
- Gaudino Meta-analysis of Medical Therapy vs CABG https://doi.org/10.1016/j.jtcvs.2022.06.003
- NOBLE https://doi.org/10.1016/S0140-6736(19)32972-1
- EXCEL 5 years https://www.nejm.org/doi/full/10.1056/nejmoa1909406
II. ASA for Primary Prevention
Daily Aspirin Challenged in Primary Stroke Prevention: ASPREE
https://www.medscape.com/viewarticle/994963
- ASPREE – All-cause mortality
- ASPREE (MACE and Bleeding) https://www.nejm.org/doi/full/10.1056/NEJMoa1805819
- ASPREE (disability) https://www.nejm.org/doi/full/10.1056/NEJMoa1800722
- JAMA Network Open Subanalysis https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2807630
III. Fish Oil
- OMEMI Substudy https://doi.org/10.1016/j.clnu.2023.07.002
- Gencer and colleagues Meta-analysis - https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.055654
- OMEMI Main Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.052209
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https://www.medscape.com/features/public/machine
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https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact [email protected]
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Antiarrhythmic drugs in patients with CAD, observational studies, GLP-1 agonists, and the subcutaneous ICD are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. AAD in Patients with CAD
- The Feasibility and Safety of Flecainide Use Among Patients With Varying Degrees of Coronary Disease
https://doi.org/10.1016/j.jacep.2022.12.021
- Three Questions for Evidence-Based Cardiac Electrophysiology
https://www.ahajournals.org/doi/full/10.1161/circoutcomes.110.957381
- The Cardiac Arrhythmia Suppression Trial (CAST) https://www.nejm.org/doi/full/10.1056/nejm198908103210608
II. GLP-1 Agonists
Tirzepatide Powers Weight Loss in Two More Pivotal Trials https://www.medscape.com/viewarticle/994889
Semaglutide Use Surges in US Adults With Type 2 Diabetes https://www.medscape.com/viewarticle/994873
- Tirzepatide Once Weekly for the Treatment of Obesity
https://www.nejm.org/doi/full/10.1056/NEJMoa2206038
- Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial
https://doi.org/10.1016/S0140-6736(23)01200-X
III. S-ICD
S-ICD Shows Virtues, Limits in 'Real World' Postmarket Study https://www.medscape.com/viewarticle/994851
- Postapproval Study of a Subcutaneous Implantable Cardioverter-Defibrillator System https://doi.org/10.1016/j.jacc.2023.05.034
- Subcutaneous or Transvenous Defibrillator Therapy https://www.nejm.org/doi/full/10.1056/NEJMoa1915932
- Letter to the Editor https://www.nejm.org/doi/full/10.1056/NEJMc2034917
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The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD.
https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact [email protected]
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Listener feedback, conduction system pacing, eating fish vs fish pills, exercise, and an RCT for diet are the topics discussed by John Mandrola,.MD, in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Listener Feedback Monitor HF and AHA
Jun 02, 2023 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/992678
- Link to the ACC Email -- https://www.acc.org/Latest-in-Cardiology/Clinical-Trials/2023/07/18/17/21/monitor-hf
- Tweet From Anthony Pearson
https://twitter.com/skepcard/status/1681288604990189574
II. Conduction System Pacing
- Clinical Outcomes in Conduction System Pacing Compared to Right Ventricular Pacing in Bradycardia https://doi.org/10.1016/j.jacep.2022.10.016
- Hormone Therapy To Prevent Disease and Prolong Life in Postmenopausal Women https://www.acpjournals.org/doi/abs/10.7326/0003-4819-117-12-1016
III. Fish Oil
Omega-3s and AF: No Added Risk From Eating Fish but High-Dose Supplement Questions Persist https://www.medscape.com/viewarticle/994559
- Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation
https://www.jacc.org/doi/full/10.1016/j.jacc.2023.05.024
- Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia https://www.nejm.org/doi/full/10.1056/nejmoa1812792
- Effect of Long-Term Marine ɷ-3 Fatty Acids Supplementation on the Risk of Atrial Fibrillation in Randomized Controlled Trials of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.055654
IV. Exercise
Even Exercise by 'Weekend Warriors' Can Cut CV Risk
https://www.medscape.com/viewarticle/994617
- Accelerometer-Derived "Weekend Warrior" Physical Activity and Incident Cardiovascular Disease https://jamanetwork.com/journals/jama/article-abstract/2807286
V. Diet
Cognitive Benefit of Highly Touted MIND Diet Questioned
https://www.medscape.com/viewarticle/994550
- Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons
https://www.nejm.org/doi/full/10.1056/NEJMoa2302368
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https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Carotid stents, the paclitaxel story now closed, inclisiran, DOAC failures, and primary vs secondary prevention are the topics John Mandrola, MD, covers in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Carotid Stenting CMS Proposal
Expanded Coverage of Carotid Stenting in CMS Draft Proposal
https://www.medscape.com/viewarticle/994315
No Added Benefit From Revascularization in Low-Risk CAS
https://www.medscape.com/viewarticle/992524
- Percutaneous Transluminal Angioplasty (PTA) of the Carotid Artery Concurrent with Stenting https://www.cms.gov/medicare-coverage-database/view/ncacal-decision-memo.aspx?proposed=Y&NCAId=311
- Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy
https://doi.org/10.1016/S0140-6736(21)01910-3
- SPACE-2 https://journals.sagepub.com/doi/10.1177/1747493019833017
- Rationale, Design, and Implementation of Intensive Risk Factor Treatment in the CREST2 Trial 10.1161/STROKEAHA.120.030730
II. Paclitaxel
FDA: No Excess Mortality Risk From Paclitaxel Stents, Balloons for Peripheral Intervention https://www.medscape.com/viewarticle/994253
- FDA Statement https://www.fda.gov/medical-devices/letters-health-care-providers/update-paclitaxel-coated-devices-treat-peripheral-arterial-disease-unlikely-increase-risk-mortality?utm_medium=email&utm_source=govdelivery#_FDA_Actions
III. Inclisiran
FDA Expands Inclisiran Statin-Adjunct Indication to Include Primary Prevention https://www.medscape.com/viewarticle/994185
- ORION 10-11 Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol https://www.nejm.org/doi/10.1056/NEJMoa1912387
- Effect of inclisiran on lipids in primary prevention: the ORION-11 trial
https://doi.org/10.1093/eurheartj/ehac615
- Inclisiran and cardiovascular events: a patient-level analysis of phase III trials https://pubmed.ncbi.nlm.nih.gov/36331326/
IV. DOAC Failure
Association of Alternative Anticoagulation Strategies and Outcomes in Patients With Ischemic Stroke While Taking a Direct Oral Anticoagulant
https://doi.org/10.1212/WNL.0000000000207422
V. Primary or Secondary Prevention
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https://www.medscape.com/features/public/machine
The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD.
https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact [email protected]
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
European HTN Guidelines, vitamin D, bempedoic acid, and leadless pacing, with some critical appraisal techniques thrown in, are the topics John Mandrola, MD, tackles in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. European Hypertension Guidelines
New ESH Hypertension Guidelines Aim for Simplified Message
https://www.medscape.com/viewarticle/993913
- 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension Endorsed by the European Renal Association (ERA) and the International Society of Hypertension (ISH)
https://pubmed.ncbi.nlm.nih.gov/37345492/
II. Vitamin D
CV Benefit From Vitamin-D Caps Hinted in Huge D-Health Trial
https://www.medscape.com/viewarticle/993996
- Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial
https://www.bmj.com/content/381/bmj-2023-075230
- Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 83 000 Individuals in 21 Randomized Clinical Trials
https://jamanetwork.com/journals/jamacardiology/fullarticle/2735646
III. Bempedoic Acid
'Striking' Benefit of Lipid Lowering in Primary Prevention
https://www.medscape.com/viewarticle/993666
- Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients
https://jamanetwork.com/journals/jama/fullarticle/2806646
- Bempedoic Acid for High-Risk Primary Prevention of Cardiovascular Disease
https://jamanetwork.com/journals/jama/fullarticle/2806647
- Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients
https://www.nejm.org/doi/full/10.1056/NEJMoa2215024
IV. Leadless Pacing
FDA Approves First Leadless Dual-Chamber Pacing System
https://www.medscape.com/viewarticle/994033
- A Dual-Chamber Leadless Pacemaker
https://www.nejm.org/doi/full/10.1056/NEJMoa2300080
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The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD.
https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Starting HF meds during hospitalization for HF, Impella, testosterone, and colchicine are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Starting HF Meds During Hospitalization for HF
Starting Indicated Heart Failure Meds In-Hospital: Progress, Opportunities https://www.medscape.com/viewarticle/993539
- Opportunities and Achievement of Medication Initiation Among Inpatients With Heart Failure With Reduced Ejection Fraction https://www.jacc.org/doi/full/10.1016/j.jchf.2023.04.015
II. Impella
- Comparative Effectiveness of Percutaneous Microaxial Left Ventricular Assist Device vs Intra-Aortic Balloon Pump or No Mechanical Circulatory Support in Patients With Cardiogenic Shock
https://jamanetwork.com/journals/jamacardiology/fullarticle/2806562
- Evidence Generation for Novel Cardiovascular Devices—Putting the Horse Back in Front of the Cart
https://jamanetwork.com/journals/jamacardiology/fullarticle/2806565
III. Testosterone
Big Trial Reassures on Heart Safety of Testosterone in Men
https://www.medscape.com/viewarticle/993322
- Cardiovascular Safety of Testosterone-Replacement Therapy
https://www.nejm.org/doi/full/10.1056/NEJMoa2215025
IV. Colchicine for CV Disease
Low-Dose Colchicine Approved for CVD: Now What?
https://www.medscape.com/viewarticle/993578
- Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction
https://www.nejm.org/doi/full/10.1056/nejmoa1912388
- Colchicine in Patients with Chronic Coronary Disease
https://www.nejm.org/doi/full/10.1056/nejmoa2021372
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Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine
https://www.medscape.com/features/public/machine
The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD.
https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
AF screening, BNP, a new SGLT2 inhibitor, a sky-is-blue study, and the UK Mini Mitral surgical trial are discussed in this week's podcast
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I AF Screening
- Effects of Atrial Fibrillation Screening According to N-Terminal Pro-B-Type Natriuretic Peptide: A Secondary Analysis of the Randomized LOOP Study https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064361
- Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study): a randomised controlled trial https://doi.org/10.1016/S0140-6736(21)01698-6
- Natural History of Subclinical Atrial Fibrillation Detected by Implanted Loop Recorders https://www.jacc.org/doi/full/10.1016/j.jacc.2019.09.050
- Prevalence and Prognostic Significance of Bradyarrhythmias in Patients Screened for Atrial Fibrillation vs Usual Care https://jamanetwork.com/journals/jamacardiology/fullarticle/2801362
- Stepwise mass screening for atrial fibrillation using N-terminal pro b-type natriuretic peptide: the STROKESTOP II study design https://doi.org/10.1093/europace/euw319
- Current misconception 3: that subgroup-specific trial mortality results often provide a good basis for individualising patient care https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068511/
II Frailty and GDMT of HFrEF
Frailty Linked to Lower Use of Guideline Treatments in HFrEF
https://www.medscape.com/viewarticle/993218
- Physical Frailty and Use of Guideline‐Recommended Drugs in Patients With Heart Failure and Reduced Ejection Fraction https://www.ahajournals.org/doi/10.1161/JAHA.122.026844
III Sotagliflozin
FDA Approves New Drug, Sotagliflozin, for Heart Failure
https://www.medscape.com/viewarticle/992518
- Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease
https://www.nejm.org/doi/full/10.1056/NEJMoa2030186
- Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure
https://www.nejm.org/doi/full/10.1056/NEJMoa2030183
IV Mini-Mitral
Support for Minimally Invasive Mitral Valve Repair: Mini Mitral Published
https://www.medscape.com/viewarticle/993191
- Minithoracotomy vs Conventional Sternotomy for Mitral Valve Repair
https://jamanetwork.com/journals/jama/article-abstract/2805908
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Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine
https://www.medscape.com/features/public/machine
The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD.
https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact: [email protected]
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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