Listener feedback on DANISH-CRT, the POET II trial, a mechanistic study in obesity and AF, the DANCODE trial of slowing CAC progression, and more on GLP-1 drugs are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback <ul> <li>DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7</li> <li>Identifying LV Posterior Wall Delay in RBBB Using Lead V8 https://doi.org/10.1016/j.jacep.2026.03.009</li> <li>Using Lead V8 as a Tool to Improve Patient Selection in CRT https://doi.org/10.1093/europace/euaf194</li> </ul> II POET II Response-Tailored or Standard-Duration Antibiotics for Endocarditis <ul> <li>POET I https://www.nejm.org/doi/10.1056/NEJMoa1808312</li> <li>POET II https://www.nejm.org/doi/full/10.1056/NEJMoa2607887</li> </ul> III Obesity and AF – A Neat Study from the Team in Prague <ul> <li>LA Remodeling and Functional Maladaptations in Obesity https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.126.014509</li> </ul> IV Reducing CAC: The DANCODE Trial <ul> <li>DANCODE Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.082363</li> </ul> V Two Big RCTs of New GLP-1 Drugs <ul> <li>TRIUMPH-1 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2604169</li> <li>SYNCHRONIZE-2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607219</li> </ul> The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.

Listener feedback on DANISH-CRT, the POET II trial, a mechanistic study in obesity and AF, the DANCODE trial of slowing CAC progression, and more on GLP-1 drugs are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7 Identifying LV Posterior Wall Delay in RBBB Using Lead V8 https://doi.org/10.1016/j.jacep.2026.03.009 Using Lead V8 as a Tool to Improve Patient Selection in CRT https://doi.org/10.1093/europace/euaf194 II POET II Response-Tailored or Standard-Duration Antibiotics for Endocarditis POET I https://www.nejm.org/doi/10.1056/NEJMoa1808312 POET II https://www.nejm.org/doi/full/10.1056/NEJMoa2607887 III Obesity and AF – A Neat Study from the Team in Prague LA Remodeling and Functional Maladaptations in Obesity https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.126.014509 IV Reducing CAC: The DANCODE Trial DANCODE Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.082363 V Two Big RCTs of New GLP-1 Drugs TRIUMPH-1 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2604169 SYNCHRONIZE-2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607219 The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Listener feedback on DANISH-CRT, the POET II trial, a mechanistic study in obesity and AF, the DANCODE trial of slowing CAC progression, and more on GLP-1 drugs are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback <ul> <li>DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7</li> <li>Identifying LV Posterior Wall Delay in RBBB Using Lead V8 https://doi.org/10.1016/j.jacep.2026.03.009</li> <li>Using Lead V8 as a Tool to Improve Patient Selection in CRT https://doi.org/10.1093/europace/euaf194</li> </ul> II POET II Response-Tailored or Standard-Duration Antibiotics for Endocarditis <ul> <li>POET I https://www.nejm.org/doi/10.1056/NEJMoa1808312</li> <li>POET II https://www.nejm.org/doi/full/10.1056/NEJMoa2607887</li> </ul> III Obesity and AF – A Neat Study from the Team in Prague <ul> <li>LA Remodeling and Functional Maladaptations in Obesity https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.126.014509</li> </ul> IV Reducing CAC: The DANCODE Trial <ul> <li>DANCODE Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.082363</li> </ul> V Two Big RCTs of New GLP-1 Drugs <ul> <li>TRIUMPH-1 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2604169</li> <li>SYNCHRONIZE-2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607219</li> </ul> The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com" rel="noopener noreferrer">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.

Oct 02 2026 This Week in Cardiology

Listener feedback, pulmonary embolism intervention, simple vs complex in BiV pacing, exercise in AF, and TAVR for paradoxical low-flow, low-gradient aortic stenosis are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback LBBP ICD Lead <ul> <li>LEADR LBBAP Trial https://pubmed.ncbi.nlm.nih.gov/41110529/</li> </ul> TRIC-I-HF trial <ul> <li>TRIC-I-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2606934</li> <li>Growth of Tricuspid Interventions in Germany https://www.jacc.org/doi/10.1016/j.jcin.2025.05.030</li> </ul> II Treatment of Acute Intermediate-High Risk PE – the PRAGUE-26 Trial <ul> <li>PRAGUE-26 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2608012</li> </ul> III Targeting CS leads in CRT devices – DANISH-CRT Trial <ul> <li>DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7</li> </ul> IV Exercise for AF, Especially When There Is LA Disease <ul> <li>Physical Activity and Risk of Incident AF in Atrial Cardiomyopathy https://www.jacc.org/doi/10.1016/j.jacadv.2026.102999</li> </ul> V Paradoxical Low-Flow, Low-Gradient AS – REBOOT-PARADOX <ul> <li>REBOOT-PARADOX trial 10.1016/j.jacc.2026.08.017</li> <li>ROTAS Trial https://heart.bmj.com/content/110/20/1223</li> </ul> The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.

Listener feedback, pulmonary embolism intervention, simple vs complex in BiV pacing, exercise in AF, and TAVR for paradoxical low-flow, low-gradient aortic stenosis are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback LBBP ICD Lead LEADR LBBAP Trial https://pubmed.ncbi.nlm.nih.gov/41110529/ TRIC-I-HF trial TRIC-I-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2606934 Growth of Tricuspid Interventions in Germany https://www.jacc.org/doi/10.1016/j.jcin.2025.05.030 II Treatment of Acute Intermediate-High Risk PE – the PRAGUE-26 Trial PRAGUE-26 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2608012 III Targeting CS leads in CRT devices – DANISH-CRT Trial DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7 IV Exercise for AF, Especially When There Is LA Disease Physical Activity and Risk of Incident AF in Atrial Cardiomyopathy https://www.jacc.org/doi/10.1016/j.jacadv.2026.102999 V Paradoxical Low-Flow, Low-Gradient AS – REBOOT-PARADOX REBOOT-PARADOX trial 10.1016/j.jacc.2026.08.017 ROTAS Trial https://heart.bmj.com/content/110/20/1223 The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Listener feedback, pulmonary embolism intervention, simple vs complex in BiV pacing, exercise in AF, and TAVR for paradoxical low-flow, low-gradient aortic stenosis are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback LBBP ICD Lead <ul> <li>LEADR LBBAP Trial https://pubmed.ncbi.nlm.nih.gov/41110529/</li> </ul> TRIC-I-HF trial <ul> <li>TRIC-I-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2606934</li> <li>Growth of Tricuspid Interventions in Germany https://www.jacc.org/doi/10.1016/j.jcin.2025.05.030</li> </ul> II Treatment of Acute Intermediate-High Risk PE – the PRAGUE-26 Trial <ul> <li>PRAGUE-26 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2608012</li> </ul> III Targeting CS leads in CRT devices – DANISH-CRT Trial <ul> <li>DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7</li> </ul> IV Exercise for AF, Especially When There Is LA Disease <ul> <li>Physical Activity and Risk of Incident AF in Atrial Cardiomyopathy https://www.jacc.org/doi/10.1016/j.jacadv.2026.102999</li> </ul> V Paradoxical Low-Flow, Low-Gradient AS – REBOOT-PARADOX <ul> <li>REBOOT-PARADOX trial 10.1016/j.jacc.2026.08.017</li> <li>ROTAS Trial https://heart.bmj.com/content/110/20/1223</li> </ul> The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com" rel="noopener noreferrer">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.

Sep 25 2026 This Week in Cardiology

Listener feedback on POET II, sham control trials in atrial fibrillation, ICDs in HCM, and agenda laundering are the topics John Mandrola, MD, discusses in this week's podcast.This podcast is intended for healthcare professionals only.To read a partial transcript or to comment, visit:https://www.medscape.com/twicI Listener FeedbackPOET II Response-Tailored or Standard-Duration ABX for Infectious Endocarditis<ul><li>POET I Trial https://www.nejm.org/doi/10.1056/NEJMoa1808312</li><li>POET II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607887</li></ul>II PVI-SHAM-AF trial Back in the News<ul><li>GAP-AF Trial https://www.ahajournals.org/doi/10.1161/circep.115.003337</li><li>PVI-SHAM-AF Trial 10.1016/S0140-6736(26)01558-8 External Link</li><li>Why Sham Studies Are a Sham in 2026 10.1016/j.hrthm.2026.09.056 External Link</li><li>The Indispensable Role of Sham Controls in Evaluating Interventional Therapies 10.1016/j.hrthm.2026.10.001 External Link</li></ul>III ICDs in HCM<ul><li>I CDs for the Prevention of SCD in High-Risk Patients with HCM https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.078597</li><li>ICDs in HCM: Editorial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079687</li></ul>IV Agenda Laundering<ul><li>How Commercial “Agenda Laundering” Shapes Critical Care https://www.bmj.com/content/395/bmj-2026-100963</li></ul>The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harringtonQuestions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.

Listener feedback on POET II, sham control trials in atrial fibrillation, ICDs in HCM, and agenda laundering are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback POET II Response-Tailored or Standard-Duration ABX for Infectious EndocarditisPOET I Trial https://www.nejm.org/doi/10.1056/NEJMoa1808312POET II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607887II PVI-SHAM-AF trial Back in the NewsGAP-AF Trial https://www.ahajournals.org/doi/10.1161/circep.115.003337PVI-SHAM-AF Trial 10.1016/S0140-6736(26)01558-8 External LinkWhy Sham Studies Are a Sham in 2026 10.1016/j.hrthm.2026.09.056 External LinkThe Indispensable Role of Sham Controls in Evaluating Interventional Therapies 10.1016/j.hrthm.2026.10.001 External LinkIII ICDs in HCMI CDs for the Prevention of SCD in High-Risk Patients with HCM https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.078597ICDs in HCM: Editorial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079687IV Agenda LaunderingHow Commercial “Agenda Laundering” Shapes Critical Care https://www.bmj.com/content/395/bmj-2026-100963The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Listener feedback on POET II, sham control trials in atrial fibrillation, ICDs in HCM, and agenda laundering are the topics John Mandrola, MD, discusses in this week's podcast.This podcast is intended for healthcare&nbsp;professionals only.To read a partial transcript or to comment, visit:https://www.medscape.com/twicI Listener FeedbackPOET II Response-Tailored or Standard-Duration ABX for Infectious Endocarditis<ul><li>POET I Trial https://www.nejm.org/doi/10.1056/NEJMoa1808312</li><li>POET II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607887</li></ul>II PVI-SHAM-AF trial Back in the News<ul><li>GAP-AF Trial https://www.ahajournals.org/doi/10.1161/circep.115.003337</li><li>PVI-SHAM-AF Trial 10.1016/S0140-6736(26)01558-8 External Link</li><li>Why Sham Studies Are a Sham in 2026 10.1016/j.hrthm.2026.09.056 External Link</li><li>The Indispensable Role of Sham Controls in Evaluating Interventional Therapies 10.1016/j.hrthm.2026.10.001 External Link</li></ul>III ICDs in HCM<ul><li>I CDs for the Prevention of SCD in High-Risk Patients with HCM https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.078597</li><li>ICDs in HCM: Editorial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079687</li></ul>IV Agenda Laundering<ul><li>How Commercial “Agenda Laundering” Shapes Critical Care https://www.bmj.com/content/395/bmj-2026-100963</li></ul>The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harringtonQuestions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com" rel="noopener noreferrer">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.

Oct 09 2026 This Week in Cardiology

Another ESC recap, listener feedback on two trials, and a paper on GLP-1 effects on inflammation from the SELECT trial are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Correction on PROFID Trial II Listener Feedback III Fifth Universal Definition of MI <ul> <li>Fifth Universal Definition of MI https://doi.org/10.1093/eurheartj/ehag101</li> <li>Foy/Mandrola Editorial on Troponin Use and Interpretation https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2777967</li> </ul> IV New ESC HF Guidelines <ul> <li>ESC Guidelines for Management of HF https://doi.org/10.1093/eurheartj/ehag100</li> <li>Sanjay Kaul on X https://x.com/kaulcsmc/status/2094959683215958158?s=20</li> <li>Geographic Disparities in TOPCAT https://pmc.ncbi.nlm.nih.gov/articles/PMC5065247/</li> </ul> V AIR STEMI Trial <ul> <li>AIR-STEMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2605373</li> <li>CR Strategies After MI https://www.jacc.org/doi/10.1016/j.jacc.2024.04.051</li> <li>PRAMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1305520</li> <li>COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775</li> <li>FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149</li> </ul> VI GLP-1 News – A SELECT Trial Secondary Analysis <ul> <li>Semaglutide and hsCRP in Patients with CVD and Obesity https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.074482</li> </ul> The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.

Another ESC recap, listener feedback on two trials, and a paper on GLP-1 effects on inflammation from the SELECT trial are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Correction on PROFID Trial II Listener Feedback III Fifth Universal Definition of MI Fifth Universal Definition of MI https://doi.org/10.1093/eurheartj/ehag101 Foy/Mandrola Editorial on Troponin Use and Interpretation https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2777967 IV New ESC HF Guidelines ESC Guidelines for Management of HF https://doi.org/10.1093/eurheartj/ehag100 Sanjay Kaul on X https://x.com/kaulcsmc/status/2094959683215958158?s=20 Geographic Disparities in TOPCAT https://pmc.ncbi.nlm.nih.gov/articles/PMC5065247/ V AIR STEMI Trial AIR-STEMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2605373 CR Strategies After MI https://www.jacc.org/doi/10.1016/j.jacc.2024.04.051 PRAMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1305520 COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775 FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149 VI GLP-1 News – A SELECT Trial Secondary Analysis Semaglutide and hsCRP in Patients with CVD and Obesity https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.074482 The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Another ESC recap, listener feedback on two trials, and a paper on GLP-1 effects on inflammation from the SELECT trial are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Correction on PROFID Trial II Listener Feedback III Fifth Universal Definition of MI <ul> <li>Fifth Universal Definition of MI https://doi.org/10.1093/eurheartj/ehag101</li> <li>Foy/Mandrola Editorial on Troponin Use and Interpretation https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2777967</li> </ul> IV New ESC HF Guidelines <ul> <li>ESC Guidelines for Management of HF https://doi.org/10.1093/eurheartj/ehag100</li> <li>Sanjay Kaul on X https://x.com/kaulcsmc/status/2094959683215958158?s=20</li> <li>Geographic Disparities in TOPCAT https://pmc.ncbi.nlm.nih.gov/articles/PMC5065247/</li> </ul> V AIR STEMI Trial <ul> <li>AIR-STEMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2605373</li> <li>CR Strategies After MI https://www.jacc.org/doi/10.1016/j.jacc.2024.04.051</li> <li>PRAMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1305520</li> <li>COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775</li> <li>FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149</li> </ul> VI GLP-1 News – A SELECT Trial Secondary Analysis <ul> <li>Semaglutide and hsCRP in Patients with CVD and Obesity https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.074482</li> </ul> The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com" rel="noopener noreferrer">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.

Sep 18 2026 This Week in Cardiology

Listener feedback on mechanical CPR devices, PFA and stroke, the Lindy effect in adopting new technology, and an ESC preview are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback on Mechanical Compression Devices for OHCA <ul> <li>Mechanical CPR Device Use and Cardiac Arrest Survival</li> </ul> https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079272 <ul> <li>PARAMEDIC trial https://www.thelancet.com/article/S0140-6736(14)61886-9/fulltext</li> <li>CIRC trial https://www.resuscitationjournal.com/article/S0300-9572(14)00128-2/fulltext</li> <li>LINC trial https://jamanetwork.com/journals/jama/fullarticle/1774037</li> <li>Cochrane Review – Mechanical vs Manual Chest Compressions for Cardiac Arrest https://pmc.ncbi.nlm.nih.gov/articles/PMC6953326/</li> </ul> II PFA and Stroke <ul> <li>Risk of Stroke and TIA With PFA vs RF Ablation https://www.ahajournals.org/doi/epub/10.1161/CIRCULATIONAHA.126.081092</li> <li>AVANT GUARD Trial https://www.nejm.org/do/10.1056/NEJMdo008538/full/</li> <li>EMBOL-AF Registry https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag217/8566008</li> </ul> III A New ICD Lead <ul> <li>LEADR LBBAP Trial https://doi.org/10.1016/j.hrthm.2026.08.030</li> </ul> IV ESC Preview <ul> <li>Mandrola's Preview of the European Society of Cardiology 2026 https://www.medscape.com/viewarticle/mandrolas-preview-european-society-cardiology-2026-2026a1000tfi</li> </ul> You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.

Listener feedback on mechanical CPR devices, PFA and stroke, the Lindy effect in adopting new technology, and an ESC preview are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback on Mechanical Compression Devices for OHCA Mechanical CPR Device Use and Cardiac Arrest Survival https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079272 PARAMEDIC trial https://www.thelancet.com/article/S0140-6736(14)61886-9/fulltext CIRC trial https://www.resuscitationjournal.com/article/S0300-9572(14)00128-2/fulltext LINC trial https://jamanetwork.com/journals/jama/fullarticle/1774037 Cochrane Review – Mechanical vs Manual Chest Compressions for Cardiac Arrest https://pmc.ncbi.nlm.nih.gov/articles/PMC6953326/ II PFA and Stroke Risk of Stroke and TIA With PFA vs RF Ablation https://www.ahajournals.org/doi/epub/10.1161/CIRCULATIONAHA.126.081092 AVANT GUARD Trial https://www.nejm.org/do/10.1056/NEJMdo008538/full/ EMBOL-AF Registry https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag217/8566008 III A New ICD Lead LEADR LBBAP Trial https://doi.org/10.1016/j.hrthm.2026.08.030 IV ESC Preview Mandrola's Preview of the European Society of Cardiology 2026 https://www.medscape.com/viewarticle/mandrolas-preview-european-society-cardiology-2026-2026a1000tfi You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Listener feedback on mechanical CPR devices, PFA and stroke, the Lindy effect in adopting new technology, and an ESC preview are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback on Mechanical Compression Devices for OHCA <ul> <li>Mechanical CPR Device Use and Cardiac Arrest Survival</li> </ul> https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079272 <ul> <li>PARAMEDIC trial https://www.thelancet.com/article/S0140-6736(14)61886-9/fulltext</li> <li>CIRC trial https://www.resuscitationjournal.com/article/S0300-9572(14)00128-2/fulltext</li> <li>LINC trial https://jamanetwork.com/journals/jama/fullarticle/1774037</li> <li>Cochrane Review – Mechanical vs Manual Chest Compressions for Cardiac Arrest https://pmc.ncbi.nlm.nih.gov/articles/PMC6953326/</li> </ul> II PFA and Stroke <ul> <li>Risk of Stroke and TIA With PFA vs RF Ablation https://www.ahajournals.org/doi/epub/10.1161/CIRCULATIONAHA.126.081092</li> <li>AVANT GUARD Trial https://www.nejm.org/do/10.1056/NEJMdo008538/full/</li> <li>EMBOL-AF Registry https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag217/8566008</li> </ul> III A New ICD Lead <ul> <li>LEADR LBBAP Trial https://doi.org/10.1016/j.hrthm.2026.08.030</li> </ul> IV ESC Preview <ul> <li>Mandrola's Preview of the European Society of Cardiology 2026 https://www.medscape.com/viewarticle/mandrolas-preview-european-society-cardiology-2026-2026a1000tfi</li> </ul> You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com" rel="noopener noreferrer">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.

Aug 28 2026 This Week in Cardiology

John Mandrola on monitoring new oral anticoagulants; the FDA's approval of Corlanor, review of cangrelor, and warning on diabetes drugs; leadless pacemaker; and electronic health records.

Apr 17 Cardiology News

John Mandrola discusses cooling after cardiac arrest, sports-related cardiac arrest, statins in the young, an antidote to factor Xa inhibitors, and CV mortality rates.

Apr 10 Cardiology News

John Mandrola reviews a new EAS statement on statins and myalgia, statins and coronary calcium, exercise benefits, a MADIT-CRT substudy, and the maintenance-of-certification debacle.

Apr 3 Cardiology News

Removal of leadless pacemakers, APEX trial, the Mediterranean diet, music therapy, and inequalities in TAVI use worldwide are discussed by Dr Mandrola in this week's podcast.

Jun 10 Cardiology News

From ACC: rate vs rhythm for postop AF, TAVR in intermediate-risk AS, PCSK9 inhibitors for statin intolerance, HOPE-3, and FIRE and ICE are discussed as well as the approval of a leadless pacemaker.

Apr 8 Cardiology News

This podcast delivers Dr. John Mandrola's summary and perspective on top news of the week that cardiologists can't miss. This podcast is intended for US health professionals only.

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