The Microbials discuss how ambrosia beetles utilize ethanol to farm fungi, and how cleaved cochlin protein sequesters bacteria in the inner ear to preserve hearing function.

Links for this episode:

• Ambrosia beetles, ethanol, and farmed fungi (PNAS)
• Cleaved cochlin protects the inner ear (Cell Host Microbe)
• Importance of flossing (ADA)

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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Michael and Vincent discuss the finding of immunity to Cas9 protein in humans, and a potential role for an oral bacterium in Alzheimer's disease.

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• Immunity to Cas9 protein in humans (Nat Med)
• P. gingivalis and Alzheimer's disease (Science)
• Clinical trial of COR388 in AD patients (clinicaltrials.gov)
• TWiM Listener survey

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Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter

How a bacterium helps dengue virus replicate in the mosquito gut, and minicells as a damage disposal mechanism in E. coli.

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Links:

• Please take the TWiM listener survey
• Bacteria help dengue virus in mosquito gut (Cell Host Micr)
• Fungus helps dengue virus in mosquito gut (TWiV 479)
• Minicells for disposal of damaged goods (mSphere)
• TWiM Listener survey

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The TWiM team explore how Lactobacillus reuteri can rescue social deficits in three mouse models of autism spectrum disorder, and the role of Salmonella persisters in undermining host defenses during antibiotic treatment.

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• Please take the
• TWiM listener surveyBacteria alter behavior in mouse autism models (Neuron)
• Mice behaving badly (TWiM 131)
• Salmonella persisters undermine host immune defenses (Science)
• Persister cells (Ann Rev Microbiol)

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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The TWiM team reveals an extremely low rate of mutation in a 2500 year old, 185 acre fungus in Michigan, and how a host-produced quorum sensing autoinducer controls the phage switch between lysis and lysogeny.

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• Huge fungus is 2500 years old (Proc Roy Soc B)
• Humongous fungus (Wikipedia)
• Host-produced autoinducer controls phage (Cell)
• These bacteria are bugged (virology blog)

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• Please take the TWiM listener survey
• Vote for NJ State Microbe
• Huge fungus is 2500 years old (Proc Roy Soc B)
• Humongous fungus (Wikipedia)
• Host-produced autoinducer controls phage (Cell)
• These bacteria are bugged (virology blog)L

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to [email protected]

The TWiM team reveals the oldest human plague from 4,900 years ago in Sweden, and engineering E. coli to become an endosymbiont in yeast, modeling the evolution of mitochondria.

Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson

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• Oldest human plague from 4,900 years ago (PNAS)
• Engineering yeast endosymbionts (PNAS)
• Letters read on TWiM 191
• TWiM Listener survey

Send your microbiology questions and comments (email or recorded audio) to "mailto:[email protected]">[email protected]

The TWiM-opods consider two stories about exosomes, vesicles that are shed from cells: those that eliminate airway pathogens, and those from the plants we eat that shape our gut microbiome.

Hosts:

Vincent Racaniello, Michael Schmidt, and Michele Swanson.

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Links for this episode

• Exosome swarms eliminate airway pathogens (J Aller Clin Immunol)
• Exosome release from Bacteria, Eukaryotes, Archaea (Infect Immun)
• Plant exosomes shape gut microbiome (Cell Host Microbe)
• Image credit
• Subscribe to MicrobeTV on YouTube
• TWiM Listener survey

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The TWiM team considers the state of the world's fungi as revealed by a report from the Kew Royal Botanical Gardens, and how Salmonella loses motility to evade host defenses.

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson

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Links for this episode:

• Subscribe to MicrobeTV on YouTube
• State of the World's Fungi 2018
• Salmonella loses motility to avoid inflammasome activation (Cell Rep)

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to [email protected]

The TWiM rock stars show how to modify gram-positive antibiotics so they can kill gram-negative cells, and bacteria that have both DNA and RNA in their genome.

Hosts: Vincent Racaniello and Michael Schmidt

Links for this episode

• Antibiotics for gram-positives that kill gram-negatives (J Med Chem)
• Sideromycin commentary (Am Council Sci Health)
• Bacterial genome with DNA and RNA (J Am Chem Soc)

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The TWiM people reveal that phages must cooperate to overcome CRISPR-Cas defenses, and the effect of the herbicide glyphosate on the gut microbiome of honey bees.

Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson

Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

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Links for this episode:

• Phages Cooperate to Overcome CRISPR-Cas Immunity (Cell)
• Glyphosate perturbs gut microbiota of honey bees (PNAS)
• Letters read on TWiM 187